上海交通大学附属第一人民医院肿瘤科是上海市三甲综合医院中最早设立的肿瘤专科，是医院“十二五”期间重点发展的学科之一。2009年，医院整合肿瘤相关学科资源，成立了肿瘤中心，学科带头人黄倩教授，中心主任王理伟教授，肿瘤中心副主任王红霞（兼肿瘤科副主任[主持，南]）、刘勇副主任医师，北部执行主任李琦主任医... [详细]
作者： Zhiao Chen;Shengli Li;Mengting Shen;Xinyuan Lu;Chunyang Bao;Di Chen;Jie Ding;Qifeng Wang;Shenglin Huang;Wenming Cong;Leng Han;Xianghuo He （5 Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China 2 Department of Biochemistry and Molecular Biology, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX 77030, USA 1 Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China 4 Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China 3 Department of Pathology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China）
出处： iScience 2020 Vol.23 No.11 P101690
关键词： Cancer;Cancer Systems Biology;Genomics;Transcriptomics.
摘要： Hepatocellular carcinoma (HCC) initiation is characterized by stepwise accumulation of molecular alterations, during which the early events are largel ...
作者： Senlin Zhao, Yushuai Mi, Bingjie Guan, Binbin Zheng, Ping Wei, Yanzi Gu, Zhengxiang Zhang, Sanjun Cai, Ye Xu, Xinxiang Li, Xuefeng He, Xinyang Zhong, Guichao Li, Zhiyu Chen, Dawei Li （Affiliations 1 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 270 Dong\'an Road, Shanghai, 200032, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\'an Road, Shanghai, 200032, China. 3 Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Street, Jinan, 250033, China. 4 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 85 Wujin Road, Shanghai, 200080, China. 5 Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong\'an Road, Shanghai, 200032, China. 6 Department of Pathology, Fudan University Shanghai Cancer Center, 270 Dong\'an Road, Shanghai, 200032, China. 7 Department of Biobank, Fudan University Shanghai Cancer Center, 270 Dong\'an Road, Shanghai, 200032, China. 8 Department of Oncology, Yijishan Hospital of Wannan Medical College, No. 2 Zheshan Road, Wuhu, 241001, Anhui, China. 9 Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\'an Road, Shanghai, 200032, China. Guichaoli11@fudan.edu.cn. 10 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong\'an Road, Shanghai, 200032, China. Guichaoli11@fudan.edu.cn. 11 Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\'an Road, Shanghai, 200032, China. chanhj75@aliyun.com. 12 Department of Medical Oncology, Fudan University Shanghai Cancer Center, 270 Dong\'an Road, Shanghai, 200032, China. chanhj75@aliyun.com. 13 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 270 Dong\'an Road, Shanghai, 200032, China. li_dawei@fudan.edu.cn. 14 Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\'an Road, Shanghai, 200032, China. li_dawei@fudan.edu.cn.）
出处： Journal of hematology & oncology 2020 Vol.13 No.1 P156
关键词： Colorectal cancer liver metastasis;Exosome;M2 macrophage polarization;Premetastatic niche;miR-934.
摘要： Background: Mounting evidence has demonstrated the vital importance of tumor-associated macrophages (TAMs) and exosomes in the formation of the premet ...
作者： Peijie Zhong, Jing Xu, Dong Yang, Yue Shen, Lu Wang, Yun Feng, Chunling Du, Yuanlin Song, Chaomin Wu, Xianglin Hu, Yangbai Sun （Affiliations 1 Department of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China. 3 Department of Gastroenterology and Hepatology, Huaihe Hospital of Henan University, 475000, Kaifeng, China. 4 Clinical Medical College, Southwest Medical University, 646000, Luzhou, China. 5 Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, 200032, Shanghai, China. 6 Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 200032, Shanghai, China. 7 Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, 200032, Shanghai, China. 8 Department of Gastroenterology and Hepatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080, Shanghai, China. 9 Department of Pulmonary and Critical Care Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, 201700, Shanghai, China. 10 Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 200032, Shanghai, China. wu.chaomin@outlook.com. 11 Department of Pulmonary and Critical Care Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, 201700, Shanghai, China. wu.chaomin@outlook.com. 12 Department of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China. xianglinhero@163.com. 13 Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China. xianglinhero@163.com. 14 Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, 200032, Shanghai, China. xianglinhero@163.com. 15 Department of Surgery Training Base, Fudan University Shanghai Cancer Center, 200032, Shanghai, China. xianglinhero@163.com. 16 Department of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China. drsunyb@fudan.edu.cn. 17 Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China. drsunyb@fudan.edu.cn.）
出处： Signal transduction and targeted therapy 2020 Vol.5 No.1 P256
摘要： Coronavirus disease-2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The infection is spreading globally and ...
作者： Jie,Xiong ;Bo-Wen,Cui ;Nan,Wang ;Yu-Ting,Dai ;Hao,Zhang ;Chao-Fu,Wang ;Hui-Juan,Zhong ;Shu,Cheng ;Bin-Shen,Ou-Yang ;Yu,Hu ;Xi,Zhang ;Bin,Xu ;Wen-Bin,Qian ;Rong,Tao ;Feng,Yan ;Jian-Da,Hu ;Ming,Hou ;Xue-Jun,Ma ;Xin,Wang ;Yuan-Hua,Liu ;Zun-Min,Zhu ;Xiao-Bin,Huang ;Li,Liu ;Chong-Yang,Wu ;Li,Huang ;Yun-Feng,Shen ;Rui-Bin,Huang ;Jing-Yan,Xu ;Chun,Wang ;De-Pei,Wu ;Li,Yu ;Jian-Feng,Li ;Peng-Peng,Xu ;Li,Wang ;Jin-Yan,Huang ;Sai-Juan,Chen ;Wei-Li,Zhao （State Key Laboratory of Medical Genomics \'(1)\' ; Shanghai Institute of Hematology [2] ; National Research Center for Translational Medicine [3] ; Shanghai Rui Jin Hospital [4] ; Shanghai Jiao Tong University School of Medicine [5] ; 197 Rui Jin Er Road [6] ; Shanghai 200025 [7] ; China. [8] ; China; School of Life Sciences and Biotechnology [9] ; Shanghai Jiao Tong University [10] ; Shanghai [11] ; Department of Otolaryngology [12] ; Department of Pathology [13] ; Institute of Hematology [14] ; Union Hospital [15] ; Tongji Medical College [16] ; Huazhong University of Science and Technology [17] ; Wuhan [18] ; Department of Hematology [19] ; Xinqiao Hospital [20] ; Third Military Medical University [21] ; Chongqing [22] ; The First Affiliated Hospital of Xiamen University [23] ; Xiamen [24] ; Fujian [25] ; The First Affiliated Hospital of Zhejiang University School of Medicine [26] ; Hangzhou [27] ; Xinhua Hospital [28] ; The Third Affiliated Hospital of Suzhou University [29] ; The First People\'s Hospital of Changzhou [30] ; Changzhou [31] ; People\'s Republic of China. [32] ; Fujian Institute of Hematology [33] ; Fujian Medical University Union Hospital [34] ; Fuzhou [35] ; Qilu Hospital of Shandong University [36] ; Jinan [37] ; Department of Medical Oncology [38] ; Shanghai Cancer Center [39] ; Fudan University [40] ; Shandong Province Hospital of Shandong University [41] ; Jiangsu Cancer Hospital [42] ; Nanjing [43] ; Henan Province People\'s Hospital [44] ; Zhengzhou [45] ; Sichuan Provincial People\'s Hospital [46] ; Chengdu [47] ; Tangdu Hospital [48] ; The Fourth Military Medical University [49] ; Xi\'an [50] ; Lanzhou University Second Hospital [51] ; Lanzhou [52] ; Gansu [53] ; Department of Oncology and Hematology [54] ; Hospital (T.C.M) Affiliated to Southwest Medical University [55] ; Luzhou [56] ; Wuxi People\'s Hospital Affiliated to Nanjing Medical University [57] ; Wuxi [58] ; The First Affiliated Hospital of Nanchang University [59] ; Nanchang [60] ; Nanjing Drum Tower Hospital [61] ; Shanghai General Hospital Affiliated to Shanghai Jiao Tong University [62] ; The First Affiliated Hospital of Soochow University [63] ; Suzhou [64] ; The Second Affiliated Hospital of Nanchang University [65] ; China; Pôle de Recherches Sino-Français en Science du Vivant et Génomique [66] ; Laboratory of Molecular Pathology [67] ; China. Electronic address: jinyan@shsmu.edu.cn. [68] ; China. Electronic address: sjchen@stn.sh.cn. [69] ; China. Electronic address: zhao.weili@yahoo.com. [70]）
出处： Cancer cell 2020 Vol.37 No.3 P403-419(e6)
关键词： Epstein-Barr virus;MYC;RAS;RNA helicase;RNA sequencing;copy number variation;genomics;histone acetylation;natural killer/T cell lymphoma;programmed cell death protein-1
摘要： Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus ...
作者： Wei-Da Wang, Guo-Yan Wu, Kun-Hao Bai, Ling-Ling Shu, Pei-Dong Chi, Si-Yuan He, Xin Huang, Qian-Yi Zhang, Liang Li, Da-Wei Wang, Yu-Jun Dai （Affiliations 1 State Key Laboratory of Oncology in South China, Guangzhou, China. 2 Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. 3 Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. 4 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Endoscopy, Sun Yat-sen University Cancer Center, Guangzhou, China. 6 The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, Texas, USA. 7 National Research Center for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.）
出处： Clinical and translational medicine 2020 Vol.10 No.6 Pe225
作者： Xinjian Liu;Xuhui Bao;Mengjie Hu;Hanman Chang;Meng Jiao;Jin Cheng;Liyi Xie;Qian Huang;Fang Li;Chuan-Yuan Li （1 Department of Dermatology, Duke University Medical Center, Durham, NC, USA 2 Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China 3 Molecular Diagnostic Laboratory of Cancer Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 4 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 5 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA 6 Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA）
出处： Nature 2020 Vol.588 No.7839 P693-698
摘要： Despite its success in achieving the long-term survival of 10–30% of treated individuals, immune therapy is still ineffective for most patients with c ...
作者： Xinjian Liu;Xuhui Bao;Mengjie Hu;Hanman Chang;Meng Jiao;Jin Cheng;Liyi Xie;Qian Huang;Fang Li;Chuan-Yuan Li （1 Department of Dermatology, Duke University Medical Center, Durham, NC, USA 2 Department of Biochemistry, Molecular Cancer Research Center, School of Medicine, Sun Yat-sen University, Shenzhen, Guangdong, China 3 Molecular Diagnostic Laboratory of Cancer Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 4 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China 5 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA 6 Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA）
出处： Nature 2020 Vol.588 No.7839 P693-698
摘要： Despite its success in achieving the long-term survival of 10–30% of treated individuals, immune therapy is still ineffective for most patients with c ...
作者： Jianming,Xu ;Rui-Hua,Xu ;Shukui,Qin ;Hongming,Pan ;Yuxian,Bai ;Yihebali,Chi ;Liwei,Wang ;Feng,Bi ;Ying,Cheng ;Tianshu,Liu ;Dong,Ma ;Lin,Shen ;Yi,Ba ;Jun,Liang ;Xin,Wang ;Thomas C C,Yau ;Brigette B,Ma ;Kun-Huei,Yeh ;Jen-Kou,Lin ;Christian,Kappeler ;JoAnn,Shapiro ;Joachim,Kalmus ;Jin,Li （The 307 Hospital of PLA Cancer Center \'(1)\' ; Beijing [2] ; China. [3] ; Sun Yat-Sen University Cancer Center [4] ; Collaborative Innovation Center for Cancer Medicine [5] ; Guangzhou [6] ; Chinese People\'s Liberation Army Cancer Center of Nanjing Bayi Hospital [7] ; Nanjing [8] ; Sir Run Run Shaw Hospital [9] ; Hangzhou [10] ; Harbin Medical University Cancer Hospital [11] ; Harbin [12] ; Cancer Hospital [13] ; Chinese Academy of Medical Sciences [14] ; Shanghai First People\'s Hospital [15] ; Shanghai [16] ; West China Hospital [17] ; Sichuan University [18] ; Chengdu [19] ; Jilin Provincial Tumor Hospital [20] ; Changchun [21] ; Zhongshan Hospital [22] ; Fudan University [23] ; Guangdong General Hospital [24] ; Guangdong [25] ; Peking University Cancer Hospital & Institute [26] ; Tianjin Medical University Cancer Hospital [27] ; Tianjin [28] ; Affiliated Hospital of Medical College [29] ; Qingdao University [30] ; Shandong [31] ; The First Affiliated Hospital of the 4th Military Medical University [32] ; Xi\'an [33] ; Queen Mary Hospital University of Hong Kong [34] ; Hong Kong [35] ; Prince of Wales Hospital [36] ; The Chinese University of Hong Kong [37] ; National Taiwan University Hospital and National Taiwan University Cancer Center [38] ; Taipei [39] ; Taiwan. [40] ; Taipei Veterans General Hospital [41] ; Bayer AG [42] ; Berlin [43] ; Germany. [44] ; Bayer HealthCare Pharmaceuticals [45] ; Whippany [46] ; New Jersey [47] ; USA. [48] ; Tongji University Shanghai East Hospital [49] ; Fudan University Shanghai Cancer Center [50]）
出处： Journal of gastroenterology and hepatology 2020 Vol.35 No.8 P1307-1316
关键词： Chinese;clinical trial;colorectal cancer;regorafenib
摘要： In the phase 3 CONCUR trial (NCT01584830), regorafenib improved overall survival (OS) versus placebo in Asian patients with treatment-refractory metas ...
作者： Wang, Qingyinga;Zhang, Qinyib;Li, Qingxianc;Zhang, Jingd,e;Zhang, Jingb （a Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China; b Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China; c Department of Gynecology and Obstetrics, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; d Department of Integrated Therapy, Shanghai Cancer Center, Fudan University, Shanghai, China; e Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China）
出处： Molecular Genetics and Genomic Medicine 2020 Vol.9 No.1 Pe1547
关键词： immune infiltration;m6A regulators;ovarian cancer;survival
摘要： Background: N 6 -methyladenosine (m 6 A) modification is one of the critical gene regulatory mechanisms implicated in cancer biology. However, the rol ...
作者： Ye Yuan;Ruonan Bo;Di Jing;Zhao Ma;Zhongling Wang;Tzu-yin Lin;Lijie Dong;Xiangdong Xue;Yuanpei Li （a Center for Smart Materials and Devices, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China; b Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, 95817, United States; c School of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, China; d Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China; e Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China; f Division of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento, 95817, United States; g College of Life Sciences, Northwest University, Xi’an, 710069, China）
出处： Nano Research 2020 Vol.13 No.2 P503-510
关键词： porphyrin;7-ethyl-10-hydroxy-camptothecin (SN-38);drug delivery;self-indication;nanotheranostics;photodynamic therapy
摘要： Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment potentials. Here, we develop an excipient-f ...
