上海交通大学附属第一人民医院肿瘤科是上海市三甲综合医院中最早设立的肿瘤专科，是医院“十二五”期间重点发展的学科之一。2009年，医院整合肿瘤相关学科资源，成立了肿瘤中心，学科带头人黄倩教授，中心主任王理伟教授，肿瘤中心副主任王红霞（兼肿瘤科副主任[主持，南]）、刘勇副主任医师，北部执行主任李琦主任医... [详细]
作者： Chao, J.-S.;Zhao, S.-L.;Ou-Yang, S.-W.;Qian, Y.-B.;Liu, A.-Q.;Tang, H.-M.;Zhong, L.;Peng, Z.-H.;Xu, J.-M.;Sun, H.-C. （a Department of General Surgery, Shanghai Organ Transplantat Medical Center, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200080, China; b Department of Colorectal Surgery, Fudan University, Shanghai Cancer Center, Shanghai, 200032, China; c Division of Critical Care, Department of Liver Surgery, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200127, China; d Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200080, China; e Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200080, China）
出处： World Journal of Gastroenterology 2019 Vol.25 No.37 P5630-5640
关键词： Infection;Liver cancer;Liver transplantation;Survival;Tumor recurrence
摘要： BACKGROUND Tumor recurrence after orthotopic liver transplantation (OLT) remains a serious threat for long-term survival of the recipients with hepato ...
作者： Cheng, J.;He, S.;Wang, M.;Zhou, L.;Zhang, Z.;Feng, X.;Yu, Y.;Ma, J.;Dai, C.;Zhang, S.;Sun, L.;Gong, Y.;Wang, Y.;Zhao, M.;Luo, Y.;Liu, X.;Tian, L.;Li, C.;Huang, Q. （a Molecular Diagnostic Laboratory of Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Songjiang District, Shanghai, 201620, China; b Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; c Department of General Surgery, Shanghai Fourth People\'s Hospital, Shanghai, China; d Department of Pharmacy, First Affiliated Hospital, School of Medicine, Soochow University, Suzhou, China; e Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; f Department of Dermatology, Duke University Medical Center, Box 3135, Durham, NC 27710, United States）
出处： Clinical Cancer Research 2019 Vol.25 No.12 P3732-3743
摘要： Purpose: Tumor repopulation is known as a major cause of treatment failure and/or tumor recurrence after radiotherapy. The underlying mechanism remain ...
作者： Yao, Z.;Zheng, Z.;Ke, W.;Wang, R.;Mu, X.;Sun, F.;Wang, X.;Garg, S.;Shi, W.;He, Y.;Liu, Z. （a Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China; b Department of Radiation Oncology, Sidney Kimmel Medical College at Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia, PA, United States; c Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China）
出处： Journal of Translational Medicine 2019 Vol.17 No.1
关键词： Bladder cancer;Brain metastasis;Machine learning;Nomogram;Overall survival
摘要： Background: This study aimed to establish and validate a nomogram for predicting brain metastasis in patients with bladder cancer (BCa) and assess var ...
作者： Wang, Y.;Zhao, M.;He, S.;Luo, Y.;Zhao, Y.;Cheng, J.;Gong, Y.;Xie, J.;Wang, Y.;Hu, B.;Tian, L.;Liu, X.;Li, C.;Huang, Q. （a Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Songjiang District, Shanghai, 201620, China; b Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; c Department of Dermatology, Duke University Medical Center, Box 3135, Durham, NC 27710, United States）
出处： Journal of Experimental and Clinical Cancer Research 2019 Vol.38 No.1
关键词： Necroptosis;Radiotherapy;RIP1/RIP3/MLKL/JNK/IL-8 pathway;Tumor repopulation
摘要： Background: Tumor cell repopulation after radiotherapy is a major cause for the tumor radioresistance and recurrence. This study aims to investigate t ...
作者： Jiang, Ying;Lin, Jun;Zhang, Jing;Lu, Shasha;Wang, Chun;Tong, Yin （1 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China 2 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China 3 Department of Integrated Therapy, Fudan University Shanghai Cancer Center, 270 Dongan Road, Shanghai, 200032, China 4 Department of Oncology, Shanghai Medical College, Fudan University, 138 Yi xue yuan Road, Shanghai, 200032, China 5 Department of Hematology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 160 Pujian Road, Shanghai 200127, China）
出处： Pathology - Research & Practice 2019 Vol.215 No.12 P152684
关键词： B7-H1;B7-H4;DLBCL;EBV;Epstein-Barr positive diffuse large B-cell lymphoma
摘要： B7-H4 and B7-H1 are expressed in tumor tissues of 13 patients with EBV+DLBCL. • There is a negative relationship between B7-H4 and B7-H1 in EBV+DLBCL. ...
作者： (AUTHOR) (AUTHOR) (AUTHOR) (AUTHOR) (AUTHOR) (AUTHOR) (AUTHOR) (AUTHOR) （1 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, 200080, Shanghai, People\'s Republic of China 2 Department of Hematology, JinHua Hospital of TCM, 439 Shuangxi West Road, 321017, Jinhua, People\'s Republic of China 3 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, 200080, Shanghai, People\'s Republic of China 4 Department of Integrated Therapy, Fudan University Shanghai Cancer Center, 270 Dongan Road, 200032, Shanghai, People\'s Republic of China）
出处： Infectious Agents & Cancer 2019 Vol.14 No.1
关键词： Apoptosis;B7-H4;Epstein-Barr virus positive diffuse large B cell lymphoma
摘要： Background: B7-H4 is among the B7 family members which may serve as a new targetable immune checkpoint molecule. It was reported that high level of se ...
作者： Li, J.;Fu, Q.;Liang, Y.;Cheng, B.;Li, X. （a Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, China; b Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China; c Shanghai Concord Medical Cancer Center, Shanghai, 200020, China; d Department of Orthopedics, Changhai Hospital, Naval Military Medical University, Shanghai, 200433, China）
出处： Journal of Molecular Modeling 2019 Vol.25 No.5
关键词： Allosteric pathway;Allostery;Conformational dynamics;Phosphorylation;Primed substrates
摘要： Glycogen synthase kinase 3β (GSK3β), a serine/threonine protein kinase, is involved in several human diseases, including type II diabetes, mood disord ...
作者： Song C;Han Y;Luo H;Qin Z;Chen Z;Liu Y;Lu S;Sun H;Zhou C （Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Gastric Surgery, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Department of Neurology, Fifth Affiliated Hospital of Zheng Zhou University, Zhengzhou, China Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）
出处： Cancer Medicine 2019 Vol.8 No.12 P5651-5661
关键词： BCL2;HOXA10;apoptosis;gastric cancer;proliferation
摘要： Homeobox A10 (HOXA10) has been implicated critical for the promotion of carcinogenesis, but the underlying mechanism between HOXA10 and malignant gast ...
作者： Fu, Qiang;Xu, Le;Wang, Yiwei;Jiang, Qi;Liu, Zheng;Zhang, Junyu;Zhou, Quan;Zeng, Han;Tong, Shanyou;Wang, Tao;Qi, Yangyang;Hu, Baoying;Fu, Hangcheng;Xie, Huyang;Zhou, Lin;Chang, Yuan;Zhu, Yu;Dai, Bo;Zhang, Weijuan;Xu, Jiejie （1 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China 2 Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3 Department of Urology, Ninth People\'\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 4 Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China 5 Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China 6 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China）
出处： European Urology 2019 Vol.75 No.5 P752-763
关键词： Clear cell renal cell carcinoma;Glutamine metabolism;Immunotherapy;Interleukin-23;Regulatory T cells;Tumor-associated macrophages
摘要： Background Glutamine addiction is a hallmark of clear cell renal cell carcinoma (ccRCC); yet whether glutamine metabolism impacts local immune surveil ...
作者： Jiang, Yang 1,2,+;Zhou, Jinpeng 1,+;Hou, Dianqi 2;Luo, Peng 1;Gao, Huiling 3;Ma, Yanju 4;Chen, Yin-Sheng 5;Li, Long 1;Zou, Dan 7;Zhang, Haiying 6;Zhang, Ye *,7;Jing, Zhitao *,1 （Affiliations 1 Department of Neurosurgery, The First Hospital of China Medical University, Shenyang City, PR China. 2 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. 3 College of Life and Health Sciences, Northeastern University, Shenyang, PR China. 4 Department of Medical Oncology, Cancer Hospital of China Medical University, Shenyang, PR China. 5 Department of Neurosurgery/Neuro-oncology, SunYat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China. 6 The First laboratory of cancer institute, the First Hospital of China Medical University, Shenyang City, PR China. 7 International Education College, Liaoning University of Traditional Chinese Medicine, Shenyang City, PR China.）
出处： The Journal of Pathology 2019 Vol.249 No.1 P26-38
关键词： PSAP;glioblastoma;mesenchymal subtype;invasion;EMT.
摘要： Mesenchymal glioblastoma (GBM) is the most aggressive subtype of GBM. Our previous study found that neurotrophic factor prosaposin (PSAP) is highly ex ...
