上海交通大学附属第一人民医院肿瘤科是上海市三甲综合医院中最早设立的肿瘤专科，是医院“十二五”期间重点发展的学科之一。2009年，医院整合肿瘤相关学科资源，成立了肿瘤中心，学科带头人黄倩教授，中心主任王理伟教授，肿瘤中心副主任王红霞（兼肿瘤科副主任[主持，南]）、刘勇副主任医师，北部执行主任李琦主任医... [详细]
作者： Guo Z;Sun L;Li B;Tian R;Zhang X;Zhang Z;Clifford SP;Liu Y;Huang J;Li X （Affiliations 1 Department of Cardiovascular Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. 2 Department of Cardiovascular Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai, China. 3 Department of Emergency and Critical Care, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. 4 Department of Intensive Care Unit, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. 5 Department of Intensive Care Unit, Fudan University Shanghai Cancer Center, Shanghai, China. 6 Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY. 7 Department of Statistics Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. 8 Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY. Electronic address: jiapeng.huang@louisville.edu. 9 Department of Cardiovascular Surgery. Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address: li.xin3@zs-hospital.sh.cn.）
出处： Journal of cardiothoracic and vascular anesthesia 2021 Vol.35 No.2 P389-397
关键词： COVID-19;ECMO;SARS-CoV-2;anticoagulation;coronavirus;extracorporeal membrane oxygenation;severe acute respiratory syndrome coronavirus 2;thrombosis.
摘要： Objective: To explore special coagulation characteristics and anticoagulation management in extracorporeal membrane oxygenation (ECMO)-assisted patien ...
作者： Zhen Guo MD;Lin Sun MD;Bailing Li MD;Rui Tian MD;Xiaolin Zhang MD;Zhongwei Zhang MD;Sean P. Clifford MD;Yuan Liu BS;Jiapeng Huang MD, PhD;Xin Li MD （7 Department of Statistics Center, Shanghai Chest Hospital, Shanghai JiaoTong University, Shanghai China 8 Department of Cardiovascular Surgery. Zhongshan Hospital, Fudan University, Shanghai China 5 Department of Intensive Care Unit, Fudan University Shanghai Cancer Center, Shanghai China 6 Department of Anesthesiology & Perioperative Medicine, University of Louisville, Louisville, KY, USA 3 Department of Emergency and Critical Care, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai China 4 Department of Intensive Care Unit, Shanghai Public Health Clinical Center, Fudan University, Shanghai China 1 Department of Cardiovascular Surgery. Shanghai Chest Hospital, Shanghai JiaoTong University, Shanghai China 2 Department of Cardiovascular Surgery, Shanghai Changhai Hospital, The Second Military Medical University, Shanghai China）
出处： Journal of Cardiothoracic and Vascular Anesthesia 2021
关键词： COVID-19;Coronavirus;SARS-CoV-2;extracorporeal membrane oxygenation;anticoagulation;thrombosis;ECMO
摘要： Objective To explore special coagulation characteristics and anticoagulation management in extracorporeal membrane oxygenation assisted patients with ...
作者： Ran Cui 1 2 , Ying Zhu 3 , Yulan Wang 4 , Xiao-Hua Chen 2 5 , Qiang Li 6 , Sheng-Ming Dai 1 , Qiang Tong 1 （Affiliations 1 Department of Rheumatology & Immunology, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital, Shanghai, China. 2 Department of Infectious Diseases, Wuhan Leishenshan Hospital, Wuhan, Hubei, China. 3 Department of Respiratory & Critical Care Medicine, Seventh Medical Center of Chinese PLA General Hospital, Beijing, China. 4 Molecular Diagnostic Laboratory of Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Infectious Diseases, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital, Shanghai, China. 6 Department of Respiratory & Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medical, Shanghai, China.）
出处： Future virology 2021 Vol.16 No.5 P321-329
关键词： COVID-19;IL-6;IL-6 receptor;IL-6R antagonists;SARS-CoV-2;adverse events;cytokine release syndrome;inflammatory response;mortality;tocilizumab.
摘要： Aim: Coronavirus disease 2019 is a life-threatening disease and how to improve survival of the patients is of great importance. Objective: To determin ...
作者： Tongde Wu 1 , Xuebing Jia 2 , Hang Feng 3 , Desheng Wu 4 （Affiliations 1 Department of Spine Surgery, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Rd, Shanghai, 200120, China. 2 Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 3 Department of Surgery of Spine and Spinal Cord, Henan Provincial People\'s Hospital, People\'s Hospital of Zhengzhou University, Zhengzhou, 450003, Henan, China. 4 Department of Spine Surgery, Shanghai East Hospital, Tongji University School of Medicine, 150 Jimo Rd, Shanghai, 200120, China. Electronic address: eastspinewudesheng@126.com.）
出处： Biochemical and biophysical research communications 2021 Vol.545 P54-61
关键词： ACTG1;Akt;Apoptosis;Inflammation;Intervertebral disc degeneration;NF-κB.
摘要： ACTG1 is a member of the actin family but is not a muscle actin gene. The ACTG1 mutation leads to hearing loss in humans, and the knockdown of ACTG1 s ...
作者： Liu Yang1;Xiaowei Yan2;Jie Chen3;Qiong Zhan4;Yingqi Hua1;Shili Xu5;Ziming Li6;Zhuo Wang7,8;Yu Dong3;Dongqing Zuo1;Min Xue8;Yin Tang2;Herschman, Harvey R5;Shun Lu6;Qihui Shi7,8;Wei Wei2,5 （1 Department of Orthopedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China 2 Institute for Systems Biology, Seattle, WA 98109 3 Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China 4 Department of Oncology, Huashan Hospital, Fudan University, Shanghai, 200040, China 5 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 6 Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China 7 Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China 8 Key Laboratory of Whole-Period Monitoring and Precise Intervention of Digestive Cancer (SMHC), Minhang Hospital, Fudan University, Shanghai, 201199, China）
出处： Proceedings of the National Academy of Sciences of the United States of America 2021 Vol.118 No.11 P1-11
关键词： circulating tumor cells;hexokinase-2;liquid biopsy;non-small cell lung cancer;single-cell sequencing
摘要： Unlike other epithelial cancer types, circulating tumor cells (CTCs) are less frequently detected in the peripheral blood of non-small cell lung cance ...
作者： Huairong Zhang # 1 2 3 , Andrea Liliam Gomez Corredor # 2 , Julia Messina-Pacheco # 2 , Qing Li 4 , George Zogopoulos 5 , Nancy Kaddour 6 , Yifan Wang 5 , Bing-Yin Shi 3 , Alex Gregorieff 2 , Jun-Li Liu 7 , Zu-Hua Gao 8 （Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Pathology, McGill University and the Research Institute of McGill University Health Centre, Montreal, QC, Canada. 3 Department of Endocrinology, The First Affiliated Hospital of Xi\'an Jiaotong University, Xi\'an, Shaanxi, China. 4 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA. 5 Department of Surgery, McGill University and the Research Institute of McGill University Health Centre, Montreal, QC, Canada. 6 Department of Medicine, McGill University and the Research Institute of McGill University Health Centre, Montreal, QC, Canada. 7 Department of Medicine, McGill University and the Research Institute of McGill University Health Centre, Montreal, QC, Canada. jun-li.liu@mcgill.ca. 8 Department of Pathology, McGill University and the Research Institute of McGill University Health Centre, Montreal, QC, Canada. zu-hua.gao@mcgill.ca.）
出处： Communications biology 2021 Vol.4 No.1 P688
关键词： PANCREATIC-CANCER PROGRESSION;UP-REGULATION;CELL-GROWTH;PROTEIN;REG3A;OVEREXPRESSION;REG3-BETA;MICE;DIFFERENTIATION;REGENERATION
摘要： Persistent acinar to ductal metaplasia (ADM) is a recently recognized precursor of pancreatic ductal adenocarcinoma (PDAC). Here we show that the ADM ...
作者： Yun Liu 1 2 3 , Honglian Wang 4 , Xin Wang 5 , Jiaqi Liu 5 , Junjian Li 1 , Xiang Wang 5 , Yun Zhang 6 7 , Zhigang Bai 6 7 , Qinghua Zhou 8 , Ying Wu 8 , Yi Shen 8 , Xiaoling Weng 2 3 , Fatao Liu 9 , Jiancheng Guo 10 , Lijun Di 11 , Olivier Gires 12 , Zhongtao Zhang 13 , Yiding Chen 14 15 , Hongxia Wang 16 （Affiliations 1 State Key Laboratory of Oncogenes and Related Genes, Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China. 2 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 3 Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 4 AITA Biomedical Research Institute, Shanghai, China. 5 Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 6 Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, 95 Yong\'an Road, Beijing, China. 7 Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center for Digestive Diseases, Beijing, China. 8 Department of Surgery, Luwan Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 9 Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, China. 10 Center for Precision Medicine, Zhengzhou University School of Medicine, Zhengzhou, China. 11 Cancer Center, Faculty of Health Science, University of Macau, Macau, China. 12 Department of Otorhinolaryngology, Grosshadern Medical Center, Ludwig Maximilians University of Munich, Munich, Germany. 13 Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, 95 Yong\'an Road, Beijing, China. zhangzht@ccmu.edu.cn. 14 Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, China. ydchen@zju.edu.cn. 15 The Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Hangzhou, Zhejiang, China. ydchen@zju.edu.cn. 16 State Key Laboratory of Oncogenes and Related Genes, Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China. whx365@126.com.）
出处： Journal of hematology & oncology 2021 Vol.14 No.1 P18
关键词： BRCA1/2;Breast cancer;Cohort;Reclassification;VUS.
摘要： Accurate interpretation of BRCA1/2 variants is critical for risk assessment and precise treatment of breast cancer (BC). Hence, the establishment of a ...
作者： Xuan Lin 1 2 3 4, Longyun Ye 1 2 3 4, Xu Wang 1 2 3 4, Zhenyu Liao 1 2 3 4, Jia Dong 1 2 3 4, Ying Yang 1 2 3 4, Rulin Zhang 5, Hao Li 1 2 3 4, Pengcheng Li 1 2 3 4, Lei Ding 1 2 3 4, Tianjiao Li 1 2 3 4, Wuhu Zhang 1 2 3 4, Shuaishuai Xu 1 2 3 4, Xuan Han 1 2 3 4, Huaxiang Xu 1 2 3 4, Wenquan Wang 1 2 3 4, Heli Gao 1 2 3 4, Xianjun Yu 1 2 3 4, Liang Liu 1 2 3 4 （Affiliations 1 Department of Pancreatic Surgery, Shanghai Cancer Center, Fudan University, Shanghai 200032, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 3 Shanghai Pancreatic Cancer Institute, Shanghai 200032, China. 4 Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. 5 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai 200080, China.）
出处： Cancers 2021 Vol.13 No.15 P3678
关键词： follicular helper T cells;immune microenvironment;immunosuppression;neoadjuvant chemotherapy;pancreatic ductal adenocarcinoma.
摘要： Immunosuppression is an important factor for the poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Follicular helper T cells (Tfh cells) play ...
作者： Senlin Zhao1,2;Bingjie Guan3;Yushuai Mi4;Debing Shi1,2;Ping Wei2,5,6;Yanzi Gu7;Sanjun Cai1,2;Ye Xu1,2;Xinxiang Li1,2;Dongwang Yan3;Mingzhu Huang2,8& Dawei Li1,2 （Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China Senlin Zhao, Debing Shi, Sanjun Cai, Ye Xu, Xinxiang Li & Dawei Li <<#>> Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China Senlin Zhao, Debing Shi, Ping Wei, Sanjun Cai, Ye Xu, Xinxiang Li, Mingzhu Huang & Dawei Li <<#>> Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Bingjie Guan & Dongwang Yan <<#>> Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China Yushuai Mi <<#>> Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China Ping Wei <<#>> Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China Ping Wei <<#>> Department of Biobank, Fudan University Shanghai Cancer Center, Shanghai, China Yanzi Gu <<#>> Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China Mingzhu Huang）
出处： Oncogene 2021 Vol.40 P4709-4724
摘要： Glycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A series of lncRNAs have been identified to function as oncoge ...
作者： Xisheng Liu # 1 , Xiaole Meng # 2 , Xiao Peng # 3 , Qianlan Yao # 4 5 , Fangming Zhu 6 , Zhongyi Ding 7 , Hongze Sun 1 , Xueni Liu 1 , Dan Li 8 , Ying Lu 9 , Huamei Tang 10 , Bin Li 11 , Zhihai Peng 12 13 （Affiliations 1 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Organ Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, China. 3 Department of Biology, Temple University, Philadelphia, PA, USA. 4 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China. 5 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 6 Department of Microbiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. 7 Laboratory Animal Center, Institute Pasteur of Shanghai, University of Chinese Academy of Sciences, Shanghai, China. 8 Shanghai Institute of Immunology and Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 9 Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 10 Department of Pathology, Xiang\'an Hospital of Xiamen University, Xiamen, China. tanghuamei2014@163.com. 11 Shanghai Institute of Immunology and Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. binli@shsmu.edu.cn. 12 Organ Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, China. pengzhihai1958@163.com. 13 Hepatobiliary and Pancreatic & Organ Transplantation Surgery Department, Xiang\'an Hospital of Xiamen University, Xiamen, China. pengzhihai1958@163.com.）
出处： Cell death & disease 2021 Vol.12 No.4 P390
摘要： Increasing evidence suggests that global downregulation of miRNA expression is a hallmark of human cancer, potentially due to defects in the miRNA pro ...
