作者： Peirong Huang;Fenghua Wang;Birendra Kumar Sah;Junhai Jiang;Zhentian Ni;Jentso Wang;Xiaodong Sun （¹Department of Ophthalmology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;²Eye Research Institute of Shanghai Jiao Tong University, Shanghai, China;³Department of Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;⁴Division of Biostatistics, University of Texas Health Science Center, Houston, USA）

出处： Scientific Reports 2015

摘要： Contrasting results have been reported regarding the associations between plasma total homocysteine (tHcy) and B vitamin levels and age-related macula ...

作者： J Yang;Y Cai;J L Jiang;L P Wan;S K Yan;C Wang （¹Department of Hematology, Shanghai General Hospital, Shanghai, Jiao Tong University School of Medicine, Shanghai, China）

出处： Blood Cancer Journal 2015

关键词： Soro Antilinfocitário/uso terapêutico;Antineoplásicos/uso terapêutico;Linfoma de Células T/terapia;Adolescente;Adulto;Criança;Terapia Combinada;Intervalo Livre de Doença;Feminino;Transplante de Células-Tronco Hematopoéticas;Humanos;Estimativa de Kaplan-Meier;Linfoma de Células T/mortalidade;Linfoma de Células T/patologia;Masculino;Pessoa de Meia-Idade;Estudos Prospectivos;Transplante Homólogo;Resultado do Tratamento;Adulto Jovem

摘要： The early experiment result in our hospital showed that anti-thymocyte globulin (ATG) inhibited the proliferation of lymphoid tumor cells in the T-cel ...

作者： Ling Zhao;Xiang-Jun Chen;Jie Zhu;Yi-Bo Xi;Xu Yang;Li-Dan Hu;Hong Ouyang;Sherrina H. Patel;Xin Jin;Danni Lin;Frances Wu;Ken Flagg;Huimin Cai;Gen Li;Guiqun Cao;Ying Lin;Daniel Chen;Cindy Wen;Christopher Chung;Yandong Wang;Austin Qiu;Emily Yeh;Wenqiu Wang;Xun Hu;Seanna Grob;Ruben Abagyan;Zhiguang Su;Harry Christianto Tjondro;Xi-Juan Zhao;Hongrong Luo;Rui Hou;J. Jefferson;P. Perry;Weiwei Gao;Igor Kozak;David Granet;Yingrui Li;Xiaodong Sun;Jun Wang;Liangfang Zhang;Yizhi Liu;Yong-Bin Yan;Kang Zhang （¹Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China;²State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China;³Shiley Eye Institute and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, 92093, California, USA;⁴State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China;⁵Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China;⁶BGI-Shenzhen, Shenzhen, 518083, China;⁷Guangzhou KangRui Biological Pharmaceutical Technology Company, Guangzhou, 510005, China;⁸CapitalBio Genomics Co., Ltd., Dongguan, 523808, China;⁹Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, 20080, China;¹⁰Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, 92093, California, USA;¹¹Department of Biochemistry, University of California Riverside, Riverside, 92521, California, USA;¹²Department of Nanoengineering, University of California, San Diego, La Jolla, 92093, California, USA;¹³King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia;¹⁴Veterans Administration Healthcare System, San Diego, 92093, California, USA;¹⁵Institute of Molecular Medicine, Peking University, Beijing, 100871, China）

出处： Nature 2015

关键词： SELENITE-INDUCED CATARACTOGENESIS;DOMINANT CONGENITAL CATARACT;HUMAN OXIDOSQUALENE CYCLASE;ALPHA-B-CRYSTALLIN;SEQUENCING DATA;CHINESE FAMILY;LENS;MUTATION;EXPRESSION;PREVENTION

摘要： The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparenc ...

作者： Yuhui Jiang;Xu Qian;Jianfeng Shen;Yugang Wang;Xinjian Li;Rui Liu;Yan Xia;Qianming Chen;Guang Peng;Shiaw-Yih Lin;Zhimin Lu （¹Brain Tumor Center and Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;²The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Cancer, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, China;³Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;⁴State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;⁵Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;⁶Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA;⁷The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030, USA）

出处： Nature Cell Biology 2015

关键词： DNA damage and repair? Non-homologous-end joining

摘要： Histone methylation regulates DNA repair. However, the mechanisms that underlie the regulation of histone methylation during this repair remain to be ...

作者： Guangjian Fan;Lianhui Sun;Peipei Shan;Xianying Zhang;Jinliang Huan;Xiaohong Zhang;Dali Li;Tingting Wang;Tingting Wei;Xiaohong Zhang;Xiaoyang Gu;Liangfang Yao;Yang Xuan;Zhaoyuan Hou;Yongping Cui;Liu Cao;Xiaotao Li;Shengping Zhang;Chuangui Wang （¹Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, East China Normal University, Shanghai, 200241, China;²Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Xinsongjiang Road, Songjiang District, Shanghai, 201620, China;³Department of General Surgery, Shanghai Eighth People’s Hospital, Shanghai, 200235, China;⁴Department of Pathology and Cell Biology, USF Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, 33612, Florida, USA;⁵Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;⁶Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Shanxi, 030001, China;⁷Key Laboratory of Medical Cell Biology, College of Translational Medicine, China Medical University, Shenyang, 110000, China）

出处： Nature Communications 2015

关键词： Carcinogênese/genética;Centrossomo/metabolismo;Fatores de Transcrição Kruppel-Like/genética;RNA Mensageiro/metabolismo;Fatores de Transcrição Sp/genética;Aneuploidia;Animais;Neoplasias da Mama/genética;Neoplasias da Mama/metabolismo;Linhagem Celular Tumoral;Imunoprecipitação da Cromatina;Neoplasias Colorretais/genética;Neoplasias Colorretais/metabolismo;Feminino;Técnicas de Silenciamento de Genes;Células HCT116;Células HeLa;Humanos;Imuno-Histoquímica;Masculino;Camundongos;Camundongos Knockout;Mitose/genética;Reação em Cadeia da Polimerase Via Transcriptase Reversa

摘要： Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of the Kruppel-like facto ...

作者： Liping · Gu/Gu L;Yuhang · Ma/Ma Y;Mingyu · Gu/Gu M;Ying · Zhang/Zhang Y;Shuai · Yan/Yan S;Na · Li/Li N;Yufan · Wang/Wang Y;Xiaoying · Ding/Ding X;Jiajing · Yin/Yin J;Nengguang · Fan/Fan N;Yongde · Peng/Peng Y （Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: pengyongde0908@126.com.）

出处： Peptides 2015

关键词： Endocrine tissue;Epithelial tissue;Humans;Spexin;Type 2 diabetes mellitus

摘要： Spexin mRNA and protein are widely expressed in rat tissues and associate with weight loss in rodents of diet-induced obesity. Its location in endocri ...

作者： Yue-Yun Lai¹;Xiao-Jun Huang¹CA1,2,3;Juan Li²;Ping Zou³;Ze-Feng Xu⁴;Hui Sun⁵;Zong-Hong Shao⁶;Dao-Bin Zhou⁷;Fang-Ping Chen⁸;Zhuo-Gang Liu⁹;Huan-Ling Zhu¹⁰;De-Pei Wu¹¹;Chun Wang¹²;Yin Zhang¹³;Yan Li¹⁴;Ming Hou¹⁵;Xin Du¹⁶;Xin Wang¹⁷;Wei Li¹⁸;Yong-Rong Lai¹⁹;Jin Zhou²⁰;Yu-Hong Zhou²¹;Mei-Yun Fang²²;Lin Qiu²³;Xiao-Min Wang²⁴;Guang-Sen Zhang²⁵;Ming Jiang²⁶;Ying-Min Liang²⁷;Lian-Sheng Zhang²⁸;Xie-Qun Chen²⁹;Hai Bai³⁰;Jin-Ying Lin³¹ （¹Peking University People's Hospital, Peking University Institute of Hematology, No. 11 Xizhimen South Street, Beijing, China;²Department of Hematology, First Affiliated Hospital of Zhongshan University, Guangzhou, China;³Department of Hematology, Wuhan Union Hospital, Wuhan, China;⁴Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China;⁵Department of Hematology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;⁶Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China;⁷Department of Hematology, Peking Union Medical College Hospital, Beijing, China;⁸Department of Hematology, Xiangya Hospital of Central-South University, Changsha, China;⁹Department of Hematology, Shengjing Hospital, China Medical University, Shenyang, China;¹⁰Department of Hematology, West China Hospital of Sichuan University, Chengdu, China;¹¹Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China;¹²Department of Hematology, Shanghai First People's Hospital, Shanghai, China;¹³Department of Hematology, Henan Province People's Hospital, Zhengzhou, China;¹⁴Department of Hematology, First Affiliated Hospital, China Medical University, Shenyang, China;¹⁵Department of Hematology, Qilu Hospital of Shandong University, Jinan, China;¹⁶Department of Hematology, Guangdong Provincial People′s Hospital, Guangzhou, China;¹⁷Department of Hematology, Shandong Provincial Hospital of Shandong University, Jinan, China;¹⁸Department of Hematology, First Affiliated Hospital of Jilin University, Changchun, China;¹⁹Department of Hematology, First Affiliated Hospital, Guangxi Medical University, Nanning, China;²⁰Department of Hematology, First Clinical College of Harbin Medical University, Harbin, China;²¹Department of Hematology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, China;²²Department of Hematology, First Affiliated Hospital of Dalian Medical University, Dalian, China;²³Harbin Institute of Hematology and Oncology, Harbin, China;²⁴Department of Hematology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China;²⁵Department of Hematology, Second Xiangya Hospital of Central-South University, Changsha, China;²⁶Department of Hematology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;²⁷Department of Hematology, Tangdu Hospital, Fourth Military Medical University, Xian, China;²⁸Department of Hematology, Second Hospital of Lanzhou University, Lanzhou, China;²⁹Department of Hematology, Xijing Hospital Affiliated to the Fourth Military Medical University, Xian, China;³⁰Department of Hematology, Lanzhou General Hospital of Lanzhou Command, Lanzhou, China;³¹Department of Hematology, People′s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China）

出处： Leukemia Research 2015

摘要： In an attempt to establish the advantages of fluorescence in situ hybridization (FISH) studies over conventional cytogenetic (CC) analysis, a total of ...

作者： Wu, Zhen^a,c;Yang, Bin^a,d;Liu, Chunxia^a,e;Liang, Ge^a;Liu, Weixia^b;Pickup, Stephen^b;Meng, Qingcheng^a;Tian, Yuke^c;Li, Shitong^d;Eckenhoff, Maryellen F.^a;Wei, Huafeng^aCAa （^aDepartment of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, 305 John Morgan Building, 3620 Hamilton Walk, Philadelphia, 19104, PA, United States;^bSmall Animal Imaging Facility, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States;^cDepartment of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;^dDepartment of Anesthesiology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China;^eDepartment of Anesthesiology, China-Japan Friendship Hospital, Beijing, China）

出处： Alzheimer Disease and Associated Disorders 2015

关键词： Alzheimer disease;amyloid;calcium;cognition;dantrolene;MRI

摘要： In this study, we investigated the long-term treatment of dantrolene on amyloid and tau neuropathology, brain volume, and cognitive function in aged t ...

作者： （1 上海交通大学附属第一人民医院急诊和危重病科　上海 200080 2 盐城市第三人民医院心内科　江苏　盐城 224001）

出处： Progress in Modern Biomedicine 2015 Vol.15 No.13 P2562-2568

关键词： Atrial fibrillation;Complications;Epidemiology;Risk factors;危险因素;并发症;心房颤动;流行病学

摘要： Atrial fibrillation(AF) was one of the most common arrhythmias. In order to prevent and control atrial fibrillation and its complications, many resear ...

作者： （1 解放军第98 医院神经外科　浙江　湖州 313000 2 湖州市药检所　浙江　湖州 313000 3 解放军第98 医院心血管内科　浙江　湖州 313000 4 上海交通大学附属第一人民医院放射科上海 200080）

出处： Progress in Modern Biomedicine 2015 Vol.15 No.14 P2625-2628

关键词： Gene expression;Glioma cell;Lentivirus;基因表达;慢病毒;胶质瘤细胞;miR-217