作者： Wu, Ying;Chen, Yongdong;Wu, Qiang;Jia, Lili;Du, Xinhua （Department of Ultrasound, Shanghai First People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, P.R. China, Department of Ophthalmology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China）

出处： Molecular medicine reports 2015

关键词： diabetic retinopathy;minocycline;apoptosis;poly (ADP-ribose) polymerase-1;electroretinogram

摘要： The present study aimed to investigate the mechanism underlying the effects of minocycline on diabetic retinopathy-associated cellular apoptosis. A to ...

作者： Xia, Jin-Rong;Chen, Ting-Ting;Li, Wei-Dong;Lu, Feng-Lin;Liu, Juan;Cai, Xiao-Gang;Lu, Qin;Yang, Cui-Ping （Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Gastroenterology, Binzhou People's Hospital, Binzhou, Shandong 256610, P.R. China, Department of Gastroenterology, Shanghai First People's Hospital, Shanghai 200080, P.R. China）

出处： Molecular medicine reports 2015

关键词： primary hepatic stellate cells;hepatic fibrosis;small interfering RNA;receptor for advanced glycation end products

摘要： Specific small interfering RNAs (siRNAs) targeting receptor for advanced glycation end products (RAGE) inhibit the expression of RAGE, -smooth muscle ...

作者： Ma, Jing;Xu, Chang Song;Gao, Feng;Chen, Ming;Li, Fan;Du, Lian Fang （Department of Ultrasound, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China, Department of Ultrasound, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Cardiovascular Ultrasound, Shanghai East Hospital Affiliated to Tongji University, Shanghai 200120, P.R. China）

出处： Molecular medicine reports 2015

关键词： ultrasound contrast agent;microbubble;nanobubble;molecular imaging;therapeutic application;bioeffects

摘要： The contrast enhanced imaging function of ultrasound contrast agents (UCAs) has been extensively investigated using physical acoustic signatures. It h ...

作者： Zhao, Sijie;Fei, Xinfeng;Liu, Te;Liu, Yan （Department of Ophthalmology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P.R. China, Department of Ophthalmology, The Branch of The First People's Hospital of Shanghai, Shanghai 200081, P.R. China, Basic Research Laboratory, Shanghai Geriatric Institute of Chinese Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China）

出处： Molecular medicine reports 2015

关键词： corneal endothelial cells;cryoinjury;Stk11-p53 signal pathway

摘要： Cryoinjury, or injury caused by extremely low temperatures, can occur in corneal endothelial cells (CECs) and lead to visual impairment. However, the ...

作者： Yiran Li;Qi Che;Yiding Bian;Qian Zhou;Feizhou Jiang;Huan Tong;Jieqi Ke;Kai Wang;Xiao-Ping Wan （Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200040, P.R. China, Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, P.R. China, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, P.R. China）

出处： International Journal of Oncology 2015

关键词： Neoplasias do Endométrio/metabolismo;Transição Epitelial-Mesenquimal;Sistema de Sinalização das MAP Quinases;Receptores do Fator Autócrino de Motilidade/metabolismo;Biomarcadores Tumorais/genética;Biomarcadores Tumorais/metabolismo;Butadienos/farmacologia;Linhagem Celular Tumoral;Transição Epitelial-Mesenquimal/efeitos dos fármacos;Feminino;Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos;Humanos;Sistema de Sinalização das MAP Quinases/efeitos dos fármacos;Nitrilas/farmacologia

摘要： Autocrine motility factor (AMF) as a cytokine and a growth factor, is known to regulate tumor cell growth and motility in the progress of various huma ...

作者： Ju, Guan-qun;Cheng, Jun;Zhong, Liang;Wu, Shuai;Zou, Xiang-yu;Zhang, Guang-yuan;Gu, Di;Miao, Shuai;Zhu, Ying-jian;Sun, Jie;Du, Tao. （Department of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Nantong Tongzhou People's Hospital, Nantong, China. Department of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Qingdao Municipal Hospital, Qingdao, China. Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Department of Urology, Henan Provincial People's Hospital, Zhengzhou, China.）

出处： PLoS One 2015

关键词： Desdiferenciação Celular;Micropartículas Derivadas de Células/metabolismo;Células Epiteliais/citologia;Fator de Crescimento de Hepatócito/metabolismo;Túbulos Renais/citologia;Células-Tronco Mesenquimais/citologia;Cordão Umbilical/citologia;Injúria Renal Aguda/genética;Injúria Renal Aguda/patologia;Animais;Apoptose/efeitos dos fármacos;Desdiferenciação Celular/efeitos dos fármacos;Proliferação de Células/efeitos dos fármacos;Micropartículas Derivadas de Células/efeitos dos fármacos;Meios de Cultivo Condicionados/farmacologia;Células Epiteliais/efeitos dos fármacos;Células Epiteliais/metabolismo;Fator de Crescimento de Hepatócito/genética;Humanos;Hipóxia/patologia;Isquemia/patologia;Masculino;Células-Tronco Mesenquimais/efeitos dos fármacos;Células-Tronco Mesenquimais/metabolismo;Quinases de Proteína Quinase Ativadas por Mitógeno/antagonistas & inibidores;Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo;Oxigênio/metabolismo;Biossíntese de Proteínas/efeitos dos fármacos;Inibidores de Proteínas Quinases/farmacologia;Proteínas Proto-Oncogênicas c-met/antagonistas & inibidores;Proteínas Proto-Oncogênicas c-met/metabolismo;RNA Mensageiro/genética;RNA Mensageiro/metabolismo;Ratos Sprague-Dawley

摘要： During acute kidney injury (AKI), tubular cell dedifferentiation initiates cell regeneration; hepatocyte growth factor (HGF) is involved in modulating ...

作者： Mu Yuan;Ming-Zhu Bai;Xu-Feng Huang;Yue Zhang;Jing Liu;Min-Hao Hu;Wei-Qian Zheng and Fan Jin （¹Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou 310006, China ; ²Department of Obstetrics and Gynecology, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai 201600, China ; ³School of Medicine, University of Wollongong and Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia）

出处： BioMed Research International 2015

关键词： INTRAUTERINE IMPLANTATION;ESTROGENIC CHEMICALS;UTERINE RECEPTIVITY;FERTILIZED OVA;ADIPOSE-TISSUE;URINARY LEVELS;RECEPTOR;PROGESTERONE;WOMEN;INFERTILITY

摘要： Endocrine disrupting chemicals (EDCs) are chemicals that have the capacity to interfere with normal endocrine systems. Two EDCs, bisphenol A (BPA) and ...

作者： Mingyue Tan;Hua Gong;Jun Wang;Le Tao;Dongliang Xu;Erdun Bao;Zhihong Liu;Jianxin Qiu （¹Department of Urology, Shanghai First People’s Hospital, Medical College of Shanghai Jiao Tong University, Shanghai, 200080, China;²Shanghai Tianyou Hospital, Tongji University, Shanghai, 200331, China）

出处： Scientific Reports 2015

关键词： Cisteína Endopeptidases/metabolismo;Regulação Neoplásica da Expressão Gênica;Metaloproteinase 13 da Matriz/genética;Proteínas Nucleares/metabolismo;Receptores Citoplasmáticos e Nucleares/metabolismo;Proteínas Repressoras/metabolismo;Transducina/metabolismo;Neoplasias da Bexiga Urinária/genética;Neoplasias da Bexiga Urinária/metabolismo;Linhagem Celular Tumoral;Cisteína Endopeptidases/genética;Humanos;Modelos Biológicos;Regiões Promotoras Genéticas;Ligação Proteica;Transporte Proteico;Proteínas Proto-Oncogênicas/metabolismo;Sumoilação;Proteínas Wnt/metabolismo;Proteína Wnt-5a;beta Catenina/metabolismo

摘要： Bladder cancer (BC) is the most popular malignant urinary cancer in China. BC has the highest incidence and mortality among all genitourinary system t ...

作者： Wujian Xu;Ying Zhu;Yunye Ning;Yuchao Dong;Haidong Huang;Wei Zhang;Qinying Sun;Qiang Li （¹Department of Respiratory Disease, Changhai Hospital, Second Military Medical University, China;²Department of Respiratory Medicine, Jinling Hospital, Nanjing, China;³Department of Respiratory Medicine, Shanghai First People’s Hospital, Shanghai Jiaotong University School of Medicine, China）

出处： Scientific Reports 2015

关键词： Lesão Pulmonar Aguda/patologia;Lipopolissacarídeos/toxicidade;Proteínas da Mielina/metabolismo;Lesão Pulmonar Aguda/etiologia;Lesão Pulmonar Aguda/mortalidade;Adenoviridae/genética;Animais;Proteína C-Reativa/genética;Proteína C-Reativa/metabolismo;Linhagem Celular;Modelos Animais de Doenças;Vetores Genéticos/genética;Vetores Genéticos/metabolismo;Imunidade Humoral;Lipopolissacarídeos/imunologia;Pulmão/metabolismo;Pulmão/patologia;Macrófagos/imunologia;Macrófagos/metabolismo;Masculino;Camundongos;Camundongos Endogâmicos C57BL;Microscopia de Fluorescência;Proteínas da Mielina/antagonistas & inibidores;Proteínas da Mielina/genética;Proteínas Nogo;Interferência de RNA;RNA Interferente Pequeno/metabolismo;Reação em Cadeia da Polimerase em Tempo Real;Componente Amiloide P Sérico/genética;Componente Amiloide P Sérico/metabolismo;Taxa de Sobrevida;Transcriptoma

摘要： Nogo-B, a member of the reticulon 4 protein family, plays a critical role in tissue repair and acute inflammation. Its role in acute lung injury (ALI) ...

作者： Junlong Zhuang;Qun Lu;Bing Shen;Xiaojing Huang;Lan Shen;Xi Zheng;Ruimin Huang;Jun Yan;Hongqian Guo （¹Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, Jiangsu, China;²Department of Urology, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China;³Model Animal Research Center, MOE Key Laboratory Model Animal for Disease Study, Nanjing University, Nanjing, 210061, Jiangsu, China;⁴Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA;⁵Nanjing Urology Research Center, Nanjing, 210008, Jiangsu, China）

出处： Scientific Reports 2015

关键词： Fibroblastos/metabolismo;RNA Longo não Codificante/metabolismo;Fator de Crescimento Transformador beta1/metabolismo;Caderinas/metabolismo;Movimento Celular/efeitos dos fármacos;Células Cultivadas;Meios de Cultivo Condicionados/farmacologia;Transição Epitelial-Mesenquimal/efeitos dos fármacos;Fibroblastos/citologia;Proteínas de Homeodomínio/genética;Proteínas de Homeodomínio/metabolismo;Humanos;Fosforilação;Interferência de RNA;RNA Longo não Codificante/antagonistas & inibidores;RNA Longo não Codificante/genética;RNA Mensageiro/metabolismo;RNA Interferente Pequeno/metabolismo;Reação em Cadeia da Polimerase em Tempo Real;Proteínas Repressoras/genética;Proteínas Repressoras/metabolismo;Transdução de Sinais/efeitos dos fármacos;Proteína Smad2/metabolismo;Fator de Crescimento Transformador beta1/genética;Fator de Crescimento Transformador beta1/farmacologia;Neoplasias da Bexiga Urinária/metabolismo;Neoplasias da Bexiga Urinária/patologia;Vimentina/metabolismo;Homeobox 2 de Ligação a E-box com Dedos de Zinco

摘要： Urinary bladder cancer (UBC) patients at muscle invasive stage have poor clinical outcome, due to high propensity for metastasis. Cancer-associated fi ...