作者： Aijun Sun,  Yong Cheng,  Yingmei Zhang,  Qian Zhang,  Shijun Wang,  Shan Tian,  Yunzeng Zou,  Kai Hu,  Jun Ren,  Junbo Ge （1 Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China 2 Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China 3 Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA 4 Heart Centre of Zhengzhou Ninth People\'s Hospital, Zhengzhou, Henan 450000, China 5 Department of Cardiology, Branch of Shanghai First People\'s Hospital, Shanghai 200050, China 6 Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai 200040, China）

出处： Journal of Molecular and Cellular Cardiology 2014 Vol.71 P92-104

关键词： ALDH2;Dilated cardiomyopathy;Doxorubicin;4-HNE;Autophagy

摘要： Mitochondrial aldehyde dehydrogenase (ALDH2) protects against cardiac injury via reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study w ...

作者： Zhou, Qianjun;Facciponte, John;Jin, Min;Shen, Qiang;Lin, Qiang （Department of Thoracic Surgery, Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY, United States Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and SJTUSM, Shanghai, China Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences, University of Texas MD Anderson Cancer Center, Houston, TX, United States）

出处： CANCER LETTERS 2014 Vol.344 No.1 P13-19

关键词： Humanized mice;Immunodeficient mice;NOD-SCID-IL2rg[sup]-/-[/sup] mice;Preclinical model;Tumor model;Xenograft

摘要： Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg(-/-) m ...

作者： Liao, Yun;Lu, Wen;Che, Qi;Yang, Tingting;Qiu, Haifeng;Zhang, Huijuan;He, Xiaoying;Wang, Jingyun;Qiu, Meiting;Zou, Yingfen;Gu, Wei;Wan, Xiaoping （1 1 Department of Obstetrics and Gynecology, International Peace Maternity & Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 2 Department of Obstetrics and Gynecology, Shanghai First People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China 3 3 Departments of Pathology and Biobank, International Peace Maternity & Child Health Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： PLoS ONE 2014 Vol.9 No.6 P1-13

关键词： Basic cancer research;Cancers and neoplasms;Gynecologic cancers;Gynecologic diseases;Medicine and health sciences;Obstetrics and gynecology;Oncology;Research Article;Women\'s health

摘要： Recent data support a role for SHARP1, a basic helix-loop-helix transcription repressor, in the regulation of malignant cell behavior in several human ...

作者： Zha, Bingbing;Huang, Xiuyan;Lin, Jun;Liu, Jun;Hou, Yingyong;Wu, Guilong （1 Department of Endocrinology, Shanghai Fifth People\'s Hospital, Fudan University, Shanghai P.R. China 2 Department of Surgery, Shanghai Sixth People\'s Hospital, Shanghai Jiaotong University, Shanghai P.R. China 3 Department of Pathology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai P.R. China 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai P.R. China）

出处： Journal of Clinical Laboratory Analysis 2014 Vol.28 No.3 P249-254

关键词： CD20;CD4;CD8;FoxP3;Graves\' disease;Hashimoto\'s thyroiditis;Regulatory T cells

摘要： Background: The autoimmune thyroid disease (AITD) is an organ-specific autoimmune disease characterized by the breakdown of self-tolerance to thyroid ...

作者： Xiao-Ying Zhu,  Tian-Hong Pan,  William G. Ondo,  Joohi Jimenez-Shahed,  Yun-Cheng Wu （1 Department of Neurology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China 2 Parkinson\'s Disease Center and Movement Disorder Clinic, Department of Neurology, Baylor College of Medicine, Houston 77030, TX, USA 3 Department of Neurology, University of Texas Health Science Center Houston, Houston, TX, USA）

出处： Journal of the Neurological Sciences 2014 Vol.342 No.1-2 P42-44

关键词： Deep brain stimulation;Multiple system atrophy;Parkinson\'s disease;Subthalamic nucleus;Young-onset

摘要： Objective: The aim of this study was to analyze outcomes after 1 year of bilateral STN deep brain stimulation (DBS) in relatively young-onset patients ...

作者： Guanghui An;Wenhui Li;Tao Yan;Shitong Li （1 Department of Anesthesiology, Shanghai First People\'s Hospital, Shanghai 200080, China 2 Department of Anesthesiology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, China）

出处： International Journal of Molecular Sciences 2014 Vol.15 No.6 P10479-10491

关键词： estrogen;estrogen receptors;G protein-coupled estrogen receptor (GPER);incisional pain

摘要： It has become increasingly apparent that the pain threshold of females and males varies in an estrogen dependent manner. To investigate the modulation ...

作者： Pang, Silin ;Wu, Huali ;Wang, Qian ;Cai, Minxuan ;Shi, Weimin ;Shang, Jing （1 1 New Drug Screening Center, China Pharmaceutical University, Nanjing, China 2 2 State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China 3 3 Shanghai First People Hospital, Shanghai, China）

出处： PLoS ONE 2014 Vol.9 No.5 P1-11

关键词： Anatomy;Biology and life sciences;Dermatology;Endocrine physiology;Endocrine-related substances;Integumentary system;Medicine and health sciences;Physiology;Psychological stress;Psychology;Research Article;Skin;Skin diseases;Skin physiology

摘要： Chronic stress can affect skin function, and some skin diseases might be triggered or aggravated by stress. Stress can activate the central hypothalam ...

作者： Yu S, Wang F, Pang CE, Yannuzzi LA, Freund KB. （1 *Department of Ophthalmology, Shanghai Jiaotong University Affiliated Shanghai First People\'s Hospital, Shanghai, China †Vitreous, Retina, Macula Consultants of New York, New York, New York ‡LuEsther T. Mertz Retinal Research Center, Manhattan Eye Ear and Throat Hospital, New York, New York §Department of Ophthalmology, Columbia University School of Medicine, New York, New York.）

出处： Retina. 2014 Vol.34 No.10 Pe31-e32

作者： Rui Liu;Duan Ma;Yiming Li;Renming Hu;Yongde Peng;Qinghua Wang （a Department of Endocrinology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai 200080, China b Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai 200040, China c Key Laboratory of Metabolic Molecular Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200030, China d Division of Endocrinology and Metabolism, Keenan Research Centre for Biomedical Science, University of Toronto, Toronto, M5B 1W8, Canada）

出处： Acta Biochimica et Biophysica Sinica 2014 Vol.46 No.8 P675-681

关键词： exendin-4 (Ex4);glucagon-like peptide-1 (GLP-1);high-fat diet (HFD);obesity;diabetes

摘要： Exendin-4 (Ex4), a peptide initially found in the saliva of the Gila monster, can activate the signaling pathway of the incretin hormone glucagon-like ...

作者： Xueying Ding;Xiaoli Hou;Shouhong Gao;Mingxue Sun;Fengwu Lin;Guojun Cai( caiemperor@163.com);Kai Xiao( kaixiaocn@gmail.com) （1 Department of Pharmacy, Shanghai First People\'s Hospital, Shanghai Jiao Tong University, Shanghai, China 2 Laboratory of Toxicology & Pharmacology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai, China 3 Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, China 4 China-Japan Union Hospital of Jilin University, Changchun, China 5 Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China）

出处： Pakistan Journal of Pharmaceutical Sciences 2014 Vol.27 No.6 P1931-1937

关键词： POLYGONUM-CUSPIDATUM;INJURY;ABSORPTION

摘要： To investigate the pharmacokinetic and bioavailability of polydatin (PD) in rats after oral and intravenous administration, a simple, rapid and sensit ...