作者： CAO Ni-da¹，ZHU Xiao-hong¹，MA Fang-qi¹，XU Yan¹，DONG Jia-huan¹，QIN Meng-meng¹，LIU Tian-shu²，ZHU Chun-chao³，GUO Wei-jian⁴，DING Hong-hua⁵，GUO Yuan-biao⁶，LIU Li-kun⁷，SONG Jin-jie⁸，WU Ji-ping⁹，CHENG Yue-lei¹⁰，ZENG Lin¹¹，ZHAO Ai-guang¹ （¹Oncology Department Ⅰ, Longhua Hospital Shanghai University of Traditional Chinese Medicine；²Oncology Department, Zhongshan Hospital, Fudan University；³Gastrointestinal Surgery Department, Renji Hospital, Shanghai Jiaotong University School of Medicine；⁴Oncology Department, Fudan University Shanghai Cancer Center；⁵Oncology Department, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine；⁶Traditional Chinese Medicine Department, Ruijin Hospital, Shanghai Jiaotong University School of Medicine；⁷Oncology Department, Shanxi Traditional Chinese Medicine Hospital；⁸Oncology Department, Xiyuan Hospital, China Academy of Chinese Medical Science；⁹Oncology Department, Yunnan Province Hospital of Traditional Chinese Medicine；¹⁰Oncology Department, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine；¹¹Shanghai New Core Biotechnology Co., Ltd.）

出处： Chinese Journal of Integrative Medicine 2024

摘要： Objective:To describe the treatment patterns and survival status of advanced gastric cancer（AGC）in China in the past two decades,and objectively evalu ...

作者： 王钧锋¹，刘静²，邓国英¹ （¹上海市第一人民医院创伤中心；²上海交通大学材料学院）

出处： 中国中西医结合杂志 2024

摘要： 创面特别是复杂创面愈合是一个顽固的临床难题^'(1)'，目前尚无理想的治疗方法。正常情况下，创面愈合是一个复杂而动态的生理过程，包括四个不同的阶段：止血、炎症、增殖和迁移、组织重塑，涉及炎性细胞浸润、上皮再生、血管生成、肉芽组织形成、胶原蛋白沉积等一系列反应^[2]

作者： 黄春梅，王宁，李雪莲，陈兰，陈梦灵，顾陈婕 （上海市第一人民医院护理部）

出处： 中国感染控制杂志 2024

关键词： 医护人员；猴痘； 知识；态度； 影响因素

摘要： 目的 分析医护人员对猴痘的知识水平、意愿及态度的影响因素。方法 采用横断面调查的方法,于2023年1—4月随机抽取上海市某三甲医院医护人员700名,应用自行编制的猴痘调查问卷,通过问卷星进行匿名调查。结果 共回收问卷612份,有效问卷581份,回收率87.43%,有效率94.93%。问卷平均得分为( ...

作者： 邹妮，朱丹，王丹，舒文，王琳，李琴 （上海市第一人民医院院感防控办公室；上海市第一人民医院检验科；上海市第一人民医院临床药学科）

出处： 中国感染控制杂志 2024

关键词： 感染预防控制；抗菌药物管理； 细菌耐药

摘要： 目的 探讨医疗机构应用感染预防控制(IPC)与抗菌药物管理(AMS)的协同模式降低细菌耐药水平的效果。方法 收集某院2015年1月1日—2022年12月31日所有住院患者医院感染管理、抗菌药物相关指标及多重耐药菌(MDRO)检出率,评估IPC联合AMS协同模式的效果。结果 与2015—2016年比较 ...

作者： Fan Yi¹，Xu Mimi¹，Tu Yuqing¹，Hu Yu²，Liu Qifa³，Zhao Weili⁴，Zhang Xiaohui⁵，Sun Zimin⁶，Niu Ting⁷，Hu Jianda⁸，Li Juan⁹，Liu Lin¹⁰，Liu Li¹¹，Wang Sanbin¹²，Gao Sujun¹³，Lai Yongrong¹⁴，Song Xianmin¹⁵，Li Zhenyu¹⁶，Wang Jingbo¹⁷，Jiang Zhongxing¹⁸，Xu Yajing¹⁹，Yan Jinsong²⁰，He Pengcheng²¹，Yang Jianmin²²，Chen Jia¹，Xu Yang¹，Huang Xiaojun⁵，Wu Depei¹ （¹National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou, Jiangsu, China；²Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China；³Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China；⁴State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China；⁵Department of Hematology, Peking University People’s Hospital, Peking University Institute of Hematology, Peking University, Beijing, China；⁶Department of Hematology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China；⁷Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China；⁸Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China；⁹Department of Hematology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China；¹⁰Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China；¹¹Department of Hematology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China；¹²Department of Hematology, General Hospital of Kunming Military Region of the People’s Liberation Army (PLA), Kunming, Yunan, China；¹³Department of Hematology and Oncology, Bethune First Hospital Of Jilin University, Changchun, Jilin, China；¹⁴Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Guilin, Guangxi, China；¹⁵Department of Hematology, Shanghai General Hospital, Shanghai, China；¹⁶Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China；¹⁷Department of Hematology, Aerospace Center Hospital, Beijing, China；¹⁸Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China；¹⁹Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China；²⁰Department of Hematology, Second Hospital of Dalian Medical University, Dalian, Liaoning, China；²¹Department of Hematology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China；²²Department of Hematology, Changhai Hospital, Shanghai, China）

出处： 中华医学杂志英文版 2024

作者： Shi Tingyan^1,2，Liu Jihong³，Zhu Jianqing⁴，Wang Xipeng⁵，Jiang Wei⁶，Lu Xin⁶，Feng Weiwei⁷，Zhou Shengtao⁸，Shen Yang⁹，Chen Gang¹⁰，Wu Zhenyu¹¹，Zou Dongling¹²，Wu Peng¹³，Yang Huijuan¹⁴，Wu Sufang¹⁵，Zhu Tao⁴，Wang Huaying¹⁴，Zhang Yingli⁴，Qiu Lihua¹⁶，Guo Xiaoqing¹⁷，Xiang Libing^1,2，Zhang Wei^18,19，Ren Yulan¹⁴，Feng Yanling³，Liu Yanfei²⁰，Chen Xiaojun²¹，Zang Rongyu^1,2 （¹Department of Gynecologic Oncology, Fudan University Zhongshan Hospital；²Institute for Ovarian Cancer, Fudan University, Shanghai, China；³Department of Gynecologic Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China；⁴Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China；⁵Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China；⁶Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China；⁷Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China；⁸Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE and State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan, China；⁹Department of Obstetrics and Gynecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China；¹⁰National Clinical Research Center for Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China；¹¹School of Public Health, Key Laboratory of Public Health Safety and Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai, China；¹²Gynecologic Oncology Center, Chongqing University Cancer Hospital, Chongqing, China；¹³Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China；¹⁴Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China；¹⁵Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China；¹⁶Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China；¹⁷Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China；¹⁸Biomedical Informatics &；¹⁹Statistics Center, School of Public Health, Fudan University, Shanghai, China；²⁰Office of Clinical Research, Fudan University Shanghai Cancer Center, Shanghai, China；²¹Department of Gynecology, the Tenth People’s Hospital of Tongji University, Shanghai, China）

出处： 中华医学杂志英文版 2024

作者： 李璇宇，张治，梁夫友 （上海交通大学船舶海洋与建筑工程学院；上海交通大学医学院上海市第一人民医院）

出处： 医用生物力学 2024

作者： 郭巧梅¹，乔理华¹，王琳¹，王薛庆¹，吴飞¹，梁小卉¹，孙玉腾²，娄加陶¹ （¹上海市第一人民医院, 上海交通大学医学院附属第一人民医院检验医学中心, 上海；²蚌埠医科大学检验医学院, 蚌埠）

出处： 中华检验医学杂志 2024

关键词： 结节病；肺；腺癌；DNA甲基化

摘要： 目的分析CT表现为结节的肺腺癌患者的组织甲基化特征。方法回顾性研究。收集2022年6月1日至2024年1月20日于上海市第一人民医院确诊为肺腺癌的70例肺结节患者。使用随机数字表法将其分为2组, 发现组40例和验证组30例。发现组中组织样本采用简并亚硫酸氢盐测序技术(RRBS)检测分析, 比较癌组织 ...

作者： 刘子实，李彤，孙晓东 （上海交通大学附属第一人民医院眼科国家眼部疾病临床医学研究中心上海市眼底病重点实验室上海眼视觉与光医学工程技术研究中心）

出处： 中华眼底病杂志 2024

关键词： 遗传性视网膜变性；环磷酸鸟苷；光转导；综述

摘要： 遗传性视网膜变性(IRD)是一组具有高度遗传异质性和临床异质性的眼底病,目前已发现超过300种基因突变与IRD有关。胞内第二信使环磷酸鸟苷(cGMP)的失调在多种IRD的发生和发展中发挥重要作用。cGMP在光感受器细胞中参与光转导过程,当cGMP水平异常增高,则会过度激活蛋白激酶G和环核苷酸门控通道 ...

作者： 丁思洁¹，马粤云²，马佳颖³ （¹丽水市人民医院肿瘤放化疗科；²上海市第一人民医院放疗科；³丽水市人民医院放射物理室）

出处： 中国微生态学杂志 2024

关键词： 可溶性尿激酶型纤溶酶原激活物受体；葡萄糖调节蛋白78；结肠癌；肠道菌群失调

摘要： 目的 探讨可溶性尿激酶型纤溶酶原激活物受体（suPAR）和葡萄糖调节蛋白78（GRP78）在结肠癌患者血清中的表达及其与肠道菌群失调的相关性。方法 选取我院2020年5月至2023年5月接收的116例结肠癌患者作为结肠癌组，另选同期健康体检者114例作为对照组，采用ELISA法检测两组血清suPAR ...