作者： Jingjing Hu;Chenglin Zhang;Lei Zhou;Qianyu Hu;Yanlong Kong;Dianwen Song;Yiyun Cheng;Yadong Zhang （Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, China Department of Orthopetics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Department of Orthopaedics, Fengxian Hospital Affiliated to Anhui University of Science and Technology, Shanghai, China Department of Orthopaedics, Fengxian Hospital Affiliated to Southern Medical University, Shanghai, China）

出处： Science China Materials

关键词： biofilm;smart hydrogels;antibacterial;enzyme;antibiotics

摘要： Biofilm-associated infections are difficult to treat in the clinics because the bacteria embedded in biofilm are ten to thousand times more resistant ...

作者： 章振林，夏维波，汪纯，岳华，尹香君，易春涛，顾文钦，游利，霍亚南，邓忠良，孙艳格，李梅 （《原发性骨质疏松症诊疗社区指导原则》编写组；上海交通大学附属第六人民医院；北京协和医院；中国疾病预防控制中心慢性非传染性疾病预防控制中心；上海市枫林社区卫生服务中心；上海交通大学附属第一人民医院；江西省人民医院；重庆医科大学附属第二医院；首都医科大学附属复兴医院月坛社区卫生服务中心）

出处： 中国全科医学

作者： Miao,Yu ;Zhi-Xiao,Fang ;Wei-Wei,Wang ;Ying,Zhang ;Zhi-Lei,Bu ;Meng,Liu ;Xin-Hua,Xiao ;Zi-Lu,Zhang ;Xing-Ming,Zhang ;Yang,Cao ;Ying-Ying,Wang ;Hu,Lei ;Han-Zhang,Xu ;Yun-Zhao,Wu ;Wei,Liu ;Ying-Li,Wu （Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. \'(1)\' ; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic MedicineChemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. [2] ; Department of Hematology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. [3] ; Department of Transfusion Medicine, Shanghai Ninth People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. [4] ; Department of Hematology, The Third Affiliated Hospital of Soochow University, The First People\'s Hospital of Changzhou, Changzhou, 213003, China. [5] ; Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. bsjys@shsmu.edu.cn. [6] ; Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic MedicineChemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. wuyingli@shsmu.edu.cn. [7]）

出处： Acta pharmacologica Sinica

关键词： AML;AMPKα;Compound C;FLT3-ITD;USP10;Wu-5;crenolanib;metformin

摘要： The kinase FLT3 internal tandem duplication (FLT3-ITD) is related to poor clinical outcomes of acute myeloid leukemia (AML). FLT3 inhibitors have prov ...

作者： Fang-Fang,Li ;Yu-Lai,Liang ;Xiao-Shuai,Han ;Ya-Na,Guan ;Jian,Chen ;Ping,Wu ;Xian-Xian,Zhao ;Qing,Jing （Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai JiaoTong University, Hongkou District, Shanghai, 200080, China. \'(1)\' ; Key Laboratory of Stem Cell Biology, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, 200031, China. [2] ; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, 200031, China. [3] ; National Facility for Protein Science, Shanghai, 201210, China. [4] ; Department of Cardiology, Changhai Hospital, Shanghai, 200433, China. [5] ; Key Laboratory of Stem Cell Biology, Shanghai Jiao Tong University School of Medicine (SJTUSM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, 200031, China. qjing@sibs.ac.cn. [6] ; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences (CAS), Shanghai, 200031, China. qjing@sibs.ac.cn. [7]）

出处： Acta pharmacologica Sinica

关键词： Gata1;P2y12;Zebrafish;erythropoiesis;primitive hematopoiesis;purinergic signaling

摘要： In the past two decades, purinergic signaling has emerged as a key regulator of hematopoiesis in physiological and pathological conditions. ADP recept ...