作者： Li Z.-J.;Du L.-F.;Luo X.-H. （Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China）

出处： Chinese Medical Sciences Journal 2015 Vol.30 No.4 P231-238

关键词： exercise echocardiography;exercise stress;gender;ventricular-vascular coupling

摘要： Objective To study the differences of cardiovascular system between men and women in response to exercise stress. Methods Forty healthy youth were tes ...

作者： Zhang, Dan-Dan;Zhang, Ji-Gang;Wu, Xin;Liu, Ying;Gu, Sheng-Ying;Zhu, Guan-Hua;Wang, Yu-Zhu;Liu, Gao-Lin;Li, Xiao-Yu （Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China）

出处： FRONTIERS IN PHARMACOLOGY 2015 Vol.6

关键词： Hepatic lipid accumulation;Inflammation;Non-alcoholic fatty liver disease;Nuciferine;Per-Arnt-Sim kinase

摘要： Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disease associated with lipotoxicity, lipid peroxidation, oxidative stress, and inflamm ...

作者： Zuo, Lingjun;Wang, Tong;Lin, Xiandong;Wang, Jijun;Tan, Yunlong;Wang, Xiaoping;Yu, Xueqing;Luo, Xingguang （Department of Psychiatry, Yale University School of Medicine, New Haven, CT, United States VA Connecticut Healthcare System, West Haven Campus, West Haven, CT, United States Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, United States Provincial Key Laboratory of Translational Cancer Medicine, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China Department of EEG & Neuroimaging, Shanghai Mental Health Center, Shanghai, China Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China Department of Neurology, Shanghai First People’s Hospital, Shanghai Jiao-Tong University, Shanghai, China Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China）

出处： GENES & GENOMICS 2015 Vol.37 No.12 P1007-1016

关键词： African;Allele;Autosome;European;Meta-analysis;Sex-difference

摘要： In the present study, we aimed to report the individual sex-different genetic markers across autosomes in European- and African-origin populations. A ...

作者： Ya-Qing Li;Ko-Pen Wang( kwang7@jhmi.edu);Su-Qin Ben( bensuqin@163.com) （1 Department of Respiratory Medicine, Zhejiang Provincial People\'s Hospital, Hangzhou 310014, China 2 Division of Pulmonary Medicine and Critical Care Medicine, Interventional Pulmonology, Johns Hopkins University School of Medicine, Baltimore, USA 3 Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China）

出处： Journal of Thoracic Disease 2015 Vol.7 Suppl 4 PS246-S255

关键词： Anatomy;Hilar;Lung cancer;Lymph node;Mediastinal;Transbronchial needle aspiration (TBNA)

摘要： Lung cancer is the leading cause of malignant-tumor-related morbidity and mortality worldwide. Transbronchial needle aspiration (TBNA) has for the pas ...

作者： Lai, Y.-Y.;Huang, X.-J.;Li, J.;Zou, P.;Xu, Z.-F.;Sun, H.;Shao, Z.-H.;Zhou, D.-B.;Chen, F.-P.;Liu, Z.-G.;Zhu, H.-L.;Wu, D.-P.;Wang, C.;Zhang, Y.;Li, Y.;Hou, M.;Du, X.;Wang, X.;Li, W.;Lai, Y.-R.;Zhou, J.;Zhou, Y.-H.;Fang, M.-Y.;Qiu, L.;Wang, X.-M.;Zhang, G.-S.;Jiang, M.;Liang, Y.-M.;Zhang, L.-S.;Chen, X.-Q.;Bai, H.;Lin, J.-Y. （a Peking University People\'s Hospital, Peking University Institute of Hematology, No. 11 Xizhimen South Street, Beijing, China; b Department of Hematology, First Affiliated Hospital of Zhongshan University, Guangzhou, China; c Department of Hematology, Wuhan Union Hospital, Wuhan, China; d Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; e Department of Hematology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; f Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China; g Department of Hematology, Peking Union Medical College Hospital, Beijing, China; h Department of Hematology, Xiangya Hospital of Central-South University, Changsha, China; i Department of Hematology, Shengjing Hospital, China Medical University, Shenyang, China; j Department of Hematology, West China Hospital of Sichuan University, Chengdu, China; k Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China; l Department of Hematology, Shanghai First People\'s Hospital, Shanghai, China; m Department of Hematology, Henan Province People\'s Hospital, Zhengzhou, China; n Department of Hematology, First Affiliated Hospital, China Medical University, Shenyang, China; o Department of Hematology, Qilu Hospital of Shandong University, Jinan, China; p Department of Hematology, Guangdong Provincial People\'s Hospital, Guangzhou, China; q Department of Hematology, Shandong Provincial Hospital of Shandong University, Jinan, China; r Department of Hematology, First Affiliated Hospital of Jilin University, Changchun, China; s Department of Hematology, First Affiliated Hospital, Guangxi Medical University, Nanning, China; t Department of Hematology, First Clinical College of Harbin Medical University, Harbin, China; u Department of Hematology, Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou, China; v Department of Hematology, First Affiliated Hospital of Dalian Medical University, Dalian, China; w Harbin Institute of Hematology and Oncology, Harbin, China; x Department of Hematology, People\'s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China; y Department of Hematology, Second Xiangya Hospital of Central-South University, Changsha, China; z Department of Hematology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China; aa Department of Hematology, Tangdu Hospital, Fourth Military Medical University, Xian, China; ab Department of Hematology, Second Hospital of Lanzhou University, Lanzhou, China; ac Department of Hematology, Xijing Hospital Affiliated to the Fourth Military Medical University, Xian, China; ad Department of Hematology, Lanzhou General Hospital of Lanzhou Command, Lanzhou, China; ae Department of Hematology, People\'s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China）

出处： Leukemia Research 2015 Vol.39 No.5 P530-535

关键词： Cytogenetics;Fluorescence in situ hybridization;Myelodysplastic syndrome

摘要： In an attempt to establish the advantages of fluorescence in situ hybridization (FISH) studies over conventional cytogenetic (CC) analysis, a total of ...

作者： Yang, J., Luo, Y., Xu, Y., Li, J., Zhang, Z., Wang, H., Shen, M., Shi, X.Email Author, Zhang, G.Email Author View Correspondence (jump link) （a Department of Radiology, Shanghai First Peoples Hospital, Shanghai Jiaotong University, Shanghai, 200080, China b Department of Radiology, Shanghai Songjiang Central Hospital, Shanghai, 201699, China c College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, China）

出处： ACS Applied Materials and Interfaces 2015 Vol.7 No.9 P5420-5428

关键词： Engineering controlled terms;Acetylation;Cells;Cytology;Dendrimers;Iron;Magnetic resonance;Magnetic resonance imaging;Metal nanoparticles;Mobile security;Nanomagnetics;Nanoparticles;Synthesis (chemical);Tumors;Engineering uncontrolled terms;Cancer cells;Cell viability assays;Concentration ranges;Iron oxide nanoparticle;Morphological observations;MR imaging;Polyamidoamine dendrimers;RGD;Engineering main heading;Iron oxides;EMTREE drug terms;arginyl-glycyl-aspartic acid;biomaterial;contrast medium;dendrimer;magnetite;metal nanoparticle;oligopeptide;polyamidoamine;polyamine;EMTREE medical terms;animal;Bagg albino mouse;cell survival;chemistry;cytology;drug effects;erythrocyte;glioma;hemolysis;male;mouse;nuclear magnetic resonance imaging;nude mouse;radiography;tissue distribution;tumor cell line;xenograft;MeSH;Animals;Biocompatible Materials;Cell Line, Tumor;Cell Survival;Contrast Media;Dendrimers;Erythrocytes;Ferrosoferric Oxide;Glioma;Hemolysis;Magnetic Resonance Imaging;Male;Metal Nanoparticles;Mice;Mice, Inbred BALB C;Mice, Nude;Oligopeptides;Polyamines;Tissue Distribution;Transplantation, Heterologous

摘要： This article reports a new approach for the synthesis of ultrasmall iron oxide nanoparticles (NPs) conjugated with Arg-Gly-Asp (RGD)-modified dendrime ...

作者： Qing-Hua Liu;Su-Qin Ben;Yang Xia;Ko-Pen Wang( kwang7@jhmi.edu);Hai-Dong Huang( hhdongbs@126.com) （1 Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250014, China 2 Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China 3 Division of Pulmonary and Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China 4 Interventional Pulmonology, Division of Pulmonary Medicine and Critical Care, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA 5 Department of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China）

出处： Journal of Thoracic Disease 2015 Vol.7 Suppl 4 PS224-S230

关键词： Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA);Transbronchial needle aspiration (TBNA)

摘要： Transbronchial needle aspiration (TBNA) is an established technique to collect cell and tissue specimens from lesions outside the airway wall, general ...

作者： Feng, Ya 1, *;Liu, Te 2, *;Dong, Su-Yan 1, *;Guo, Yan-Jie 1;Jankovic, Joseph 3;Xu, Huaxi 4, 5;Wu, Yun-Cheng 1 （a Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong, University School of Medicine, Shanghai, 200080, China; b Shanghai Geriatric Institute of Chinese Medicine Longhua, Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China; c Parkinson\'s Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, United States; d Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience Medical College Xiamen University, Xiamen, Fujian Province, China; e Sanford-Burnham Medical Research Institute, La Jolla, CA, United States）

出处： Journal of Neurochemistry 2015 Vol.134 No.4 P668-676

关键词： H3K9-ac;H3K9-me3;p53;resveratrol;SIRT1.

摘要： The protein deacetylase SIRT1 has been recognized to exert its protective effect by directly deacetylasing histone and many other transcriptional fact ...

作者： Zhao, Ling;Chen, Xiang-Jun;Zhu, Jie;Xi, Yi-Bo;Yang, Xu;Hu, Li-Dan;Ouyang, Hong;Patel, Sherrina H;Jin, Xin;Lin, Danni;Wu, Frances;Flagg, Ken;Cai, Huimin;Li, Gen;Cao, Guiqun;Lin, Ying;Chen, Daniel;Wen, Cindy;Chung, Christopher;Wang, Yandong （1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [3] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.;1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi\'an 710032, China.;State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.;BGI-Shenzhen, Shenzhen 518083, China.;State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.;1] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [2] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;BGI-Shenzhen, Shenzhen 518083, China.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] Guangzhou KangRui Biological Pharmaceutical Technology Company, Guangzhou 510005, China.;Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.;Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.;1] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [2] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.;1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] CapitalBio Genomics Co., Ltd., Dongguan 523808, China.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Ophthalmology, Shanghai First People\'s Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 20080, China.;Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA.;Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.;State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.;State Key Laboratory of Membrane Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;Guangzhou KangRui Biological Pharmaceutical Technology Company, Guangzhou 510005, China.;Department of Biochemistry, University of California Riverside, Riverside, California 92521, USA.;1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA.;King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia.;Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA.;BGI-Shenzhen, Shenzhen 518083, China.;Department of Ophthalmology, Shanghai First People\'s Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai 20080, China.;BGI-Shenzhen, Shenzhen 518083, China.;1] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [2] Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA.;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.;Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi\'an 710032, China.;1] Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China [2] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China [3] Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA [4] Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, USA [5] Veterans Administration Healthcare System, San Diego, California 92093, USA.;）

出处： Nature 2015 Vol.523 No.7562 P607-611

关键词： SELENITE-INDUCED CATARACTOGENESIS;DOMINANT CONGENITAL CATARACT;HUMAN OXIDOSQUALENE CYCLASE;ALPHA-B-CRYSTALLIN;SEQUENCING DATA;CHINESE FAMILY;LENS;MUTATION;EXPRESSION;PREVENTION

摘要： The human lens is comprised largely of crystallin proteins assembled into a highly ordered, interactive macro-structure essential for lens transparenc ...

作者： Feng Jiao;Hai Hu;Ting Han;Cuncun Yuan;Lei Wang;Ziliang Jin;Zhen Guo;Liwei Wang （1 Department of Medical Oncology and Pancreatic Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China 2 Shanghai Key Laboratory of Pancreatic Diseases, Shanghai 201620, China 3 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China）

出处： International Journal of Molecular Sciences 2015 Vol.16 No.4 P6677-6693

关键词： cancer stem cells;long noncoding RNA;MALAT-1;stemness

摘要： Cancer stem cells (CSCs) play a vital role in tumor initiation, progression, metastasis, chemoresistance, and recurrence. The mechanisms that maintain ...