作者： 黄国，高晓龙，孙媛媛，周根泉，张玉峰 （上海市宝山区罗店医院放射科；上海交通大学附属上海市第一人民医院放射科）

出处： 中国中西医结合影像学杂志 2024

关键词： CT小肠造影；CT结肠造影；联合；回盲部病变

摘要： 目的：分析CT 小肠与结肠联合造影（CTE+C）对回盲部病变的诊断结果，探讨其临床应用价值。方法：收集经临床随诊或手术病理证实的50 例回盲部病变患者的CT 图像，均先后行常规腹部CT 平扫和CTE+C 检查，比较2 种方法的病变检出率，并分析回盲部病变的CTE+C 图像特点。结果：回盲部病变检出率 ...

作者： Zheng-Yang Li，Yu-Qing Mao，Qian Hua，Yong-Hong Sun，Hai-Yan Wang，Xuan-Guang Ye，Jing-Kian Hu，Ya-Jie Wang，Miao Jiang （Department of Gastroenterology, Jinshan Hospital of Fudan University；Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine；Department of Gastroenterology, Dalian Friendship Hospital；Department of Pathology, Jinshan Hospital of Fudan University）

出处： World Journal of Gastroenterology 2024

关键词： Diarrhea-predominant irritable bowel syndrome；Serotonin receptor 2B；Transient receptor potential vanilloid type-1；Visceral hypersensitivity；Abdominal pain

作者： Guantong Sun¹;Xiaodong Li¹;Pengcheng Liu²;Yao Wang¹;Cheng Yang¹;Shuhong Zhang¹;Lei Wang¹;Xiaoqing Wang¹ （¹Department of Orthopedics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China）

出处： Frontiers in Pharmacology 2024

关键词： PPARδ;osteoarthritis;autophagy;apoptosis;AKT/mTOR signaling

摘要： Osteoarthritis (OA) is the most prevalent degenerative joint disease, and PPARs are involved in its pathogenesis; however, the specific mechanisms by ...

作者： Chao Li¹;Jiajun Qin¹;Fei Xue¹;Zhaoli Shen¹;Qi Lin¹;Yajun Xue²;Xianzhen Chen¹ （¹Department of Neurosurgery, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;²Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Frontiers in Neurology 2024

关键词： atypical meningioma;gross total resection;radiation therapy;overall survival;age

摘要： BackgroundThis study aimed to investigate the effects of adjuvant beam radiation therapy (ABRT) on overall survival (OS) in patients with primary sing ...

作者： Yang Xue  ¹, Pengqi Yin  ², Hongping Chen  ¹, Guozhong Li  ³, Di Zhong  ¹ （Affiliations ¹ Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, China. ² Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Neurology, Heilongjiang Provincial Hospital, Harbin, China.）

出处： Autoimmunity 2024

关键词： IFN- therapy;Multiple sclerosis;drug responsiveness;prognostic model construction;survival analysis.

摘要： Interferon-beta (IFN-β) is one of the classical drugs for immunomodulatory therapy in relapsing-remitting multiple sclerosis (RRMS) patients, but the ...

作者： Chang Gao¹;Nan Sun¹;Jinying Xie²;Jiehao Li²;Lin Tao¹;Lijuan Guo¹;Lan Shi³;Xiaojin He⁴;Xiaoting Shen⁵;Hua Wang¹;Pan Yang⁶;Adrian Covaci⁷;Yichao Huang⁸ （¹Department of Toxicology, School of Public Health, Center for Big Data and Population Health of IHM, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China;²Department of Public Health and Preventive Medicine, China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, China;³NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui Province, China;⁴Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui Province, China;⁵Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China;⁶Department of Public Health and Preventive Medicine, China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, China;Corresponding authors at: Clinical Research Center, Suzhou Hospital of Anhui Medical University, Anhui Medical University, 616 Bianyang 3rd Rd, Suzhou 234099, China (Y. Huang). Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, 601 Huangpu W Ave, Guangzhou, 510632, China (P. Yang).;⁷Toxicological Center, University of Antwerp, Wilrijk, Belgium;⁸Clinical Research Center, Suzhou Hospital of Anhui Medical University, Anhui Medical University, Suzhou, China;Department of Toxicology, School of Public Health, Center for Big Data and Population Health of IHM, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China;Corresponding authors at: Clinical Research Center, Suzhou Hospital of Anhui Medical University, Anhui Medical University, 616 Bianyang 3rd Rd, Suzhou 234099, China (Y. Huang). Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, 601 Huangpu W Ave, Guangzhou, 510632, China (P. Yang).）

出处： Environment International 2024

关键词： Endocrine disrupting chemicals;Semen quality;Mixture effect;Seminal plasma;Omega-3 polyunsaturated fatty acids

摘要： Isolated effects of single endocrine-disrupting chemicals (EDCs) on male reproductive health have been studied extensively, but their mixture effect r ...

作者： Ming Tong  ¹, Yun Bai  ², Jiao Lyu  ³, Ling Ren  ¹, Linyu Zhang  ^{4   5}, Mudi Yao  ¹, Xiaoyan Han  ¹, Xiumiao Li  ^{4   5}, Dan Li  ¹, Pei-Quan Zhao  ³, Qin Jiang  ^{4   5}, Biao Yan  ^{1   6} （Affiliations ¹ Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. ² College of Information Science, Shanghai Ocean University, Shanghai, China. ³ Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. ⁴ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China. ⁵ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Clinical and translational medicine 2024

作者： Ming Tong  ¹, Yun Bai  ², Xiaoyan Han  ¹, Lingjie Kong  ¹, Ling Ren  ¹, Linyu Zhang  ³, Xiumiao Li  ⁴, Jin Yao  ⁵, Yan Biao  ⁶ （Affiliations ¹ Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China. ² College of Information Science, Shanghai Ocean University, Shanghai, 201306, China. ³ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China; The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ⁴ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ⁵ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China; The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. Electronic address: jinyao1972@126.com. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: biao.yan@fdeent.org.）

出处： Experimental eye research 2024

关键词： Age-related macular degeneration;Choroidal neovascularization;Endothelial heterogeneity;Single-cell sequencing.

摘要： Choroidal neovascularization (CNV) is a hallmark of neovascular age-related macular degeneration (nAMD) and a major contributor to vision loss in nAMD ...

作者： Xiaoye Shi ^{#  1   2}, Gengwen Deng ^{#  1   3}, Haiteng Wen  ^{1   2}, Anqi Lin  ¹, Haitao Wang  ⁴, Lingxuan Zhu  ^{1   5}, Weiming Mou  ^{1   6}, Zaoqu Liu  ^{7   8}, Xiaohua Li  ⁹, Jian Zhang  ¹, Quan Cheng  ^{10   11}, Peng Luo  ¹ （Affiliations ¹ Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. ² The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. ³ The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. ⁴ Thoracic Surgery Branch, Centre for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA. ⁵ Department of Aetiology and Carcinogenesis, National Cancer Centre, National Clinical Research Centre for Cancer, Cancer Hospital, Changping Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ⁶ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Key Laboratory of Proteomics, Beijing Proteome Research Centre, National Centre for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China. ⁸ Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China. ⁹ Department of Respiratory and Critical Care Medicine, Sixth People's Hospital of Chengdu, Chengdu, Sichuan, China. ¹⁰ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. ¹¹ National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China.）

出处： Journal of global health 2024

摘要： Background: This study was designed to evaluate the effects of body mass index (BMI) and weight change on the risk of developing cancer overall and ca ...

作者： Lingfeng Tong  ¹, Zhangbing Chen  ¹, Yangyang Li  ², Xinxia Wang  ¹, Changjie Yang  ³, Yakui Li  ¹, Yemin Zhu  ¹, Ying Lu  ⁴, Qi Liu  ⁵, Nannan Xu  ¹, Sijia Shao  ¹, Lifang Wu  ¹, Ping Zhang  ¹, Guangyu Wu  ⁶, Xiaoyu Wu  ⁷, Xiaosong Chen  ³, Junwei Fang  ⁸, Renbing Jia  ⁹, Tianle Xu  ¹⁰, Bin Li  ¹¹, Liang Zheng  ⁷, Junling Liu  ¹², Xuemei Tong  ¹³ （Affiliations ¹ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ² Unit of Immune and Metabolic Regulation, School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China. ³ Department of Liver Surgery, RenJi Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. ⁴ Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College of Fudan University, Shanghai 200032, China. ⁵ Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA. ⁶ Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China. ⁷ Key Laboratory of Pediatric Hematology and Oncology, Ministry of Health, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. ⁸ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200032, China. ⁹ Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. ¹⁰ Center for Brain Science of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200062, China; Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ¹¹ Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ¹² Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai Synvida Biotechnology Co., Ltd, Shanghai, China. Electronic address: liujl@shsmu.edu.cn. ¹³ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: xuemeitong@shsmu.edu.cn.）

出处： Cell metabolism 2024

关键词： GalNAc-siRNA conjugates;MAFLD;inosine;metabolic dysfunction-associated fatty liver disease;mitochondrial function;transketolase.

摘要： Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and prote ...