作者： Hongjie Chen^1,2;Yiming Zhong^3,2;Weilin Sang¹;Cong Wang¹;Haiming Lu¹;Peng Lai¹;Libo Zhu¹CA1;Jinzhong Ma¹CA2 （¹Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;²These authors contributed equally to this work.;³Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China）

出处： Biochemical and Biophysical Research Communications 2024

摘要： Osteoarthritis is a highly prevalent joint disease; however, effective treatments are lacking. Protopine (PTP) is an isoquinoline alkaloid with potent ...

作者： Junjia Tang  ^{1   2}, Yichao Jin  ¹, Feng Jia  ¹, Tao Lv  ¹, Anatol Manaenko  ³, Lin-Feng Zhang  ¹, Zeyu Zhang  ¹, Xin Qi  ⁴, Yajun Xue  ², Bin Zhao  ¹, Xiaohua Zhang  ¹, John H Zhang  ⁵, Jianfei Lu  ^{6   7}, Qin Hu  ⁸ （Affiliations ¹ Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. ² Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ³ Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. ⁴ Discipline of Neuroscience, Department of Physiology and Anatomy, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ⁵ Department of Physiology and Pharmacology, Loma Linda University, Loma Linda, CA, USA. ⁶ Discipline of Neuroscience, Department of Physiology and Anatomy, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. aflycow@126.com. ⁷ Songjiang Institute and Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. aflycow@126.com. ⁸ Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. huqinle20010709@126.com.）

出处： Translational stroke research 2024

作者： Lingxuan Zhu  ¹, Jiahua Pan  ², Weiming Mou  ³, Longxin Deng  ⁴, Yinjie Zhu  ², Yanqing Wang  ², Gyan Pareek  ⁵, Elias Hyams  ⁵, Benedito A Carneiro  ⁶, Matthew J Hadfield  ⁶, Wafik S El-Deiry  ⁷, Tao Yang  ⁸, Tao Tan  ⁹, Tong Tong  ¹⁰, Na Ta  ¹¹, Yan Zhu  ¹¹, Yisha Gao  ¹¹, Yancheng Lai  ¹², Liang Cheng  ¹³, Rui Chen  ¹⁴, Wei Xue  ¹⁵ （Affiliations ¹ Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Changping Laboratory, Beijing, China. ² Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. ³ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Urology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China. ⁵ Department of Surgery (Urology), Brown University Warren Alpert Medical School, Providence, RI, USA; Minimally Invasive Urology Institute, Providence, RI, USA. ⁶ The Legorreta Cancer Center at Brown University, Lifespan Cancer Institute, Providence, RI, USA. ⁷ The Legorreta Cancer Center at Brown University, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Pathology & Laboratory Medicine, The Warren Alpert Medical School of Brown University, The Joint Program in Cancer Biology, Brown University and Lifespan Health System, Division of Hematology/Oncology, The Warren Alpert Medical School of Brown University, Providence, RI, USA. ⁸ Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ⁹ Faculty of Applied Sciences, Macao Polytechnic University, Address: R. de Luís Gonzaga Gomes, Macao, China. ¹⁰ College of Physics and Information Engineering, Fuzhou University, Fujian 350108, China. ¹¹ Department of Pathology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai 200433, China. ¹² Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; The First School of Clinical Medicine, Southern Medical University, Guangzhou, China. ¹³ Department of Surgery (Urology), Brown University Warren Alpert Medical School, Providence, RI, USA; Department of Pathology and Laboratory Medicine, Department of Surgery (Urology), Brown University Warren Alpert Medical School, Lifespan Health, and the Legorreta Cancer Center at Brown University, Providence, RI, USA. Electronic address: liang_cheng@yahoo.com. ¹⁴ Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Electronic address: drchenrui@foxmail.com. ¹⁵ Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Electronic address: uroxuewei@163.com.）

出处： Cell reports. Medicine 2024

关键词： artificial intelligence;machine learning;pathology;prostate cancer;whole-slide image.

摘要： Prostate cancer (PCa) is a common malignancy in males. The pathology review of PCa is crucial for clinical decision-making, but traditional pathology ...

作者： Xiaoping Yi  ^{1   2   3   4   5   6}, Huien Zhan ^{#  7}, Jun Lyu ^{#  8}, Juan Du ^{#  7}, Min Dai  ⁹, Min Zhao  ¹⁰, Yu Zhang  ⁹, Cheng Zhou  ¹¹, Xin Xu  ¹², Yi Fan  ¹³, Lin Li  ¹⁴, Baoxia Dong  ¹⁵, Xinya Jiang  ^{7   11}, Zeyu Xiao  ¹⁶, Jihao Zhou  ¹⁷, Minyi Zhao  ¹⁸, Jian Zhang  ¹⁹, Yan Fu  ¹, Tingting Chen  ¹⁷, Yang Xu  ¹³, Jie Tian  ²⁰, Qifa Liu  ²¹, Hui Zeng  ²² （Affiliations ¹ Department of Radiology, Xiangya Hospital, Central South University, Changsha, China. ² National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Changsha, China. ³ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Central South University, Changsha, China. ⁴ Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha, China. ⁵ Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China. ⁶ Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China. ⁷ Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, China. ⁸ Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China. ⁹ Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China. ¹⁰ Department of Nuclear Medicine, The Third Xiangya Hospital, Central South University, Changsha, China. ¹¹ Department of Hematology, Xiangya Hospital, Central South University, Changsha, China. ¹² Department of Geriatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. ¹³ Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. ¹⁴ Department of Hematology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China. ¹⁵ Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai,, China. ¹⁶ The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, The First Affiliated Hospital of Jinan University, Guangzhou, China. ¹⁷ Department of Hematology, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China. ¹⁸ Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. ¹⁹ Department of Hematology, The Third Xiangya hospital, Central South University, Changsha, China. ²⁰ CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China. tian@ieee.org. ²¹ Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China. liuqifa628@163.com. ²² Department of Hematology, The First Affiliated Hospital of Jinan University, Guangzhou, China. androps2011@hotmail.com.）

出处： BMC cancer 2024

关键词： Acute myeloid leukemia;CT-derived features;Chest computed tomography;Nomogram;Prognosis.

摘要： Background: The identification of survival predictors is crucial for early intervention to improve outcome in acute myeloid leukemia (AML). This study ...

作者： Li Kuang PhD¹;Hanyu Hu MSN¹;Shule Xiang MSN¹;Hui Zhang PhD¹;Guangnan Liu MSN¹;Rui Tai MSN²;Lingyun Wang RN³;Yu Sheng PhD(Professor)¹CA1 （¹School of Nursing, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China;²Department of Nursing, Shanghai General Hospital, Shanghai, China;³Beijing Desheng Community Health Service Center, Beijing, China）

出处： Geriatric Nursing 2024

摘要： Aim Older people with sensory impairment are more likely to have smaller and weaker social network due to their reduced ability, which lowers their qu ...

作者： Yilu Zheng¹;Yichao Du²;Gareth R. Williams³;Ying Zhu⁴;Tong Wang¹;Yanyan Zhang¹;Jianxiang Xu¹;Junzi Wu⁴CA1;Fan Li⁵CA2;Li-Min Zhu¹CA3 （¹College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, PR China;²Department of Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, PR China;³UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK;⁴The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Traditional Chinese Medicine, Kunming 650500, PR China;⁵Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, PR China）

出处： Nano Energy 2024

摘要： The nature of the tumor microenvironment (TME) is often a hindrance to effective cancer therapy and results in treatment failure. Here, a nanoparticle ...

作者： Yu Wen^1,2;Yibaina Wang^3,2;Renjie Chen¹;Yi Guo¹;Jialu Pu¹;Jianwen Li³CA1;Huixun Jia^1,4CA2;Zhenyu Wu¹CA3 （¹School of Public Health, Key Laboratory of Public Health Safety and Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China;²These authors have contributed equally to this work.;³China National Center for Food Safety Risk Assessment, Beijing 100022, China;⁴National Clinical Research Center for Ophthalmic Diseases, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Fundus Diseases, Shanghai 200080, China）

出处： Eco-Environment & Health 2024

关键词： Hyperuricemia;Organochlorine pesticide;NHANES;Weighted quantile sum;Quantile g-computation;Bayesian kernel machine regression

摘要： The association between the exposure of organochlorine pesticides (OCPs) and serum uric acid (UA) levels remained uncertain. In this study, to investi ...

作者： Xiangwu Geng^1,2;Yifan Tang^1,2;Bo Yuan^1,2;Yuya Dai^1,2;Han-Ping Yu³;Zhi-Chao Xiong³CA1;Ying-Jie Zhu³CA2;Xiongsheng Chen^1,4CA3 （¹Spine Center, Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai 200003, PR China;²These authors contributed equally to this work.;³State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China;⁴Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China）

出处： Chemical Engineering Journal 2024

摘要： Artificial construction of tissue engineering implants with bone-mimicking structure and osteogenic function is of great significance for bone regener ...

作者： Zhen Peng ^{#  1}, Beijie Qi ^{#  2   3}, Zhiwen Luo ^{#  4}, Yaying Sun  ¹, Xingyu Zhang  ¹, Jinrong Lin  ⁴, Jinhui Pang  ¹, Peng Zhang  ⁴, Zhihu Zhao  ⁵, Xianwen Wang  ⁶, Jiwu Chen  ⁷ （Affiliations ¹ Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiaotong University, 85# Wujin Road, Hongkou District, Shanghai, 200080, China. ² Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China. ³ Shanghai Medicine College, Fudan University, Shanghai, 201399, China. ⁴ Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, 200080, China. ⁵ Department of Orthopaedics, Tianjin Hospital, No. 406, Jiefangnan Road, Hexi District, Tianjin, 300000, China. gukezzh@126.com. ⁶ School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, China. xianwenwang@ahmu.edu.cn. ⁷ Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiaotong University, 85# Wujin Road, Hongkou District, Shanghai, 200080, China. jeevechen@gmail.com.）

出处： Journal of nanobiotechnology 2024

关键词： Cell membrane;Fibrosis;Frozen shoulder;Nanoparticle;microRNA.

摘要： As a common musculoskeletal disorder, frozen shoulder is characterized by thickened joint capsule and limited range of motion, affecting 2-5% of the g ...

作者： Lei Zhang  ¹, Yiwu Sun  ², Xin Sui  ¹, Jian Zhang  ¹, Jingshun Zhao  ¹, Runfeng Zhou  ¹, Wenjia Xu  ¹, Chengke Yin  ¹, Zhaoyi He  ¹, Yufei Sun  ¹, Chang Liu  ¹, Ailing Song  ³, Fei Han  ¹ （Affiliations ¹ Department of Anesthesiology, Harbin Medical University Cancer Hospital, Harbin, China. ² Department of Anesthesiology, Dazhou Central Hospital, Dazhou, China. ³ Department of Anesthesiology, Shanghai Jiao Tong University First People's Hospital (Shanghai General Hospital), Shanghai, China.）

出处： ESC heart failure 2024

关键词： Acute heart failure;Arterial blood gas;Medical Information Mart for Intensive Care IV;Partial pressure of arterial carbon dioxide.

摘要： Aims: Both hypercapnia and hypocapnia are common in patients with acute heart failure (AHF), but the association between partial pressure of arterial ...