作者： Yihan Wang;Junwei Fang;Tian Niu;Xindan Xing;Hanying Wang;Xin Shi;Yujuan Liu;Xinyi Liu;Chong Chen;Kun Liu （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, No. 100 Haining Road, Shanghai, 20080, China. ² Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, No. 100 Haining Road, Shanghai, 20080, China. cicyheart@163.com. ³ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, No. 100 Haining Road, Shanghai, 20080, China. drliukun@sjtu.edu.cn.）

出处： Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 0

关键词： Angiopoietin-1;Angiopoietin-2;Biomarkers;Diabetic retinopathy.

摘要： Purpose: To investigate the predictive role of serum angiopoietin-1 and angiopoietin-2 (Ang-1/Ang-2) in evaluating the severity of diabetic retinopath ...

作者： Yushuai Mi;Quanhui Li;Bingtian Liu;Dehai Wang;Ziping Liu;Tianshi Wang;Yuan Wang;Yifeng Zang;Yan Zhou;Yugang Wen;Yinlu Ding （Affiliations ¹ Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Street, Jinan, 250033, China. ² Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 85 Wujin Road, Shanghai, 200080, China. ³ Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Street, Jinan, 250033, China. dingyinlu@126.com.）

出处： Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 0

关键词： Gastric cancer;Glycolysis;Prognosis;uMtCK.

摘要： Background: Ubiquitous mitochondrial creatine kinase (uMtCK) transfers high-energy phosphates from mitochondrially generated ATP to creatine to genera ...

作者： Chao Li;Zhenbo Zhang;Yixia Yang;Hong Liao （Affiliations ¹ Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China. ² Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. ³ Department of Lab Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.）

出处： Cancer medicine 0

关键词： Lactobacillus;HPV16;cervical diseases;cervicovaginal microbiota;community state type;pyrosequencing.

摘要： Background: High-risk human papillomavirus (hrHPV) infection is a key factor that alters cervicovaginal microbiota patterns and causes cervical intrae ...

作者： Stewart J Wiseman;Jun-Fang Zhang;Calum Gray;Charlene Hamid;Maria Del C Valdés Hernández;Lucia Ballerini;Michael J Thrippleton;Cameron Manning;Michael Stringer;Emilie Sleight;Susana Muñoz Maniega;Alasdair Morgan;Yajun Cheng;Carmen Arteaga;Dany Jaime Garcia;Una Clancy;Fergus N Doubal;Baljean Dhillon;Tom MacGillivray;Yun-Cheng Wu;Joanna M Wardlaw （Affiliations ¹ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. ² UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK. ³ Edinburgh Imaging Facilities, Edinburgh Imaging, University of Edinburgh, UK. ⁴ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. ⁶ NHS Lothian Princess Alexandra Eye Pavilion, UK.）

出处： Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 0

关键词： OCTA;capillary branching;cerebrovascular reactivity;perivascular spaces;vessel density.

摘要： Cerebral small vessel disease (SVD) is a cause of stroke and dementia. Retinal capillary microvessels revealed by optical coherence tomography angiogr ...

作者： Ningning Wang;Entao Li;Huifang Deng;Lanxin Yue;Lei Zhou;Rina Su;Baokun He;Chengcai Lai;Gaofu Li;Yuwei Gao;Wei Zhou;Yue Gao （Affiliations ¹ Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, China. ² Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. ³ Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China. ⁴ College of Veterinary Medicine, Jilin Agricultural University, Changchun, 130022, China. ⁵ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.）

出处： Journal of pharmaceutical analysis 0

关键词： Cytokine storm;Inosine;Interleukin 6 (IL-6);SARS-CoV-2;TANK-binding kinase 1 (TBK1).

摘要： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storms constitute the primary cause of coronavirus disease 19 (COVID-19) ...

作者： Yuxiang Zhang;Na Li;Zhiyong Ji;Haowei Bai;Ningjing Ou;Ruhui Tian;Peng Li;Erlei Zhi;Yuhua Huang;Jingpeng Zhao;Yaqin Han;Jing Zhang;Yuchuan Zhou;Zheng Li;Chencheng Yao （Affiliations ¹ Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. ³ CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, 200031, China. ⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. ⁵ Reproductive Medical Department, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. ⁶ State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, 211100, China. ⁷ Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁸ The Reproductive Medicine Research Center, the Sixth Affiliated Hospital of Sun Yat-sen University, 17 Shougouling Road, Guangzhou, 510620, China. zhangj559@mail.sysu.edu.cn. ⁹ The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. zhouych@sibcb.ac.cn. ¹⁰ Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. lizhengboshi@sjtu.edu.cn. ¹¹ Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yaochencheng@126.com.）

出处： Journal of human genetics 0

摘要： Non-obstructive azoospermia (NOA) is characterized by the failure of sperm production due to testicular disorders and represents the most severe form ...

作者： Yi Zheng;Jing Chen;Xin-Ran Song;Mei-Qi Chang;Wei Feng;Hui Huang;Cai-Xia Jia;Li Ding;Yu Chen;Rong Wu （Affiliations ¹ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China. ² Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. ³ Central Laboratory of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, PR China. ⁴ Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Tongji University School of Medicine, Tongji University, Shanghai, 200070, PR China. Electronic address: dingli@tongji.edu.cn. ⁵ Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China. Electronic address: chenyuedu@shu.edu.cn. ⁶ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wurong7111@sjtu.edu.cn.）

出处： Biomaterials 0

关键词： Antitumor immunotherapy;Innate immunity;Manganese;Synergistic therapy;cGAS-STING pathway.

摘要： As the clinical efficacy of immunotherapy for triple-negative breast cancer (TNBC) remains limited, exploring new immunotherapy approaches is still in ...

作者： Weidong Wu;Zhihua Han;Kai Hu;Chun Chen （Affiliations ¹ State Key Laboratory of Material Processing and Die and Mould Technology and School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, PR China. Electronic address: wu_windowx@hust.edu.cn. ² Trauma Center, Department of Orthopaedics and Traumatology, Shanghai General Hospital, Shanghai Jiaotong University, 200003, Shanghai, PR China. Electronic address: hzhdoc@hotmail.com. ³ Wenzhou Medical University, Wenzhou, 325000, PR China. Electronic address: 574797885@qq.com. ⁴ Department of Orthopedic Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325000, PR China. Electronic address: chenchunkk@163.com.）

出处： Asian journal of surgery 0

摘要： Taking recent changes in media markets seriously, we suggest a deeper reflection of the term “media market” in close connection to the term “value.” R ...

作者： Hong Lang;Hang Zhang;Mengqing Ma;Xin Wan;Yuyang Chen;Qing Sun;Changchun Cao （Affiliations ¹ Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, 109 Longmian Road, Nanjing, Jiangsu 211166, China. ² Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Xinsongjiang Road, Shanghai 201620, China. ³ Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu 210006, China. ⁴ Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, 109 Longmian Road, Nanjing, Jiangsu 211166, China. Electronic address: caochangchun@njmu.edu.cn.）

出处： Clinica chimica acta; international journal of clinical chemistry 0

关键词： Acute kidney injury;Cardiac surgery;Follistatin-like 1;Prediction;Protein array technology.

摘要： Background: Acute kidney injury (AKI) is a severe complication after cardiac surgery. The early prediction of AKI can facilitate timely intervention a ...

作者： Lulu Liu;Xin Guo;Yao Wang;Guo Li;Yanyan Yu;Yang Song;Chenhui Zeng;Zhilou Ding;Yuanjun Qiu;Feifei Yan;Yi-Xiang Zhang;Caiqi Zhao;Yan Zhang;Yali Dou;Peter Atadja;En Li;He Wang （Affiliations ¹ Novartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA 02139, USA; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China. ² Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China. ³ Institut Pasteur of Shanghai, 320 Yueyang Road, Shanghai 200031, China. ⁴ Department of Hematology, Shanghai General Hospital affiliated to Shanghai Jiao Tong University, No. 650 Songjiang Road, Shanghai 201620, China. ⁵ Department of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90007, USA. ⁶ Novartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA 02139, USA; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China. Electronic address: he.wang@novartis.com.）

出处： Biochimica et biophysica acta. Molecular basis of disease 0

关键词： MLL-rearranged leukemia;Myc targets;Ribosome genes;Wdr5.

摘要： WD repeat domain 5 (WDR5) is a prominent target for pharmacological inhibition in cancer through its scaffolding role with various oncogenic partners ...