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作者: 韩思杨,孙晓东 (上海交通大学附属第一人民医院眼科国家眼部疾病临床医学研究中心上海市眼部疾病临床医学研究中心上海市眼底病重点实验室上海眼视觉与光医学工程技术研究中心上海市眼科疾病精准诊疗工程技术研究中心)

出处: 中华实验眼科杂志 2024

关键词: 感光细胞;凋亡;磷酸戊糖途径;氧化应激;脂质代谢;综述

摘要: 感光细胞是一种特殊的神经上皮细胞,在视觉信号的产生和传导中具有重要作用,其主要通过大量摄取葡萄糖进行糖代谢以满足生理需求。而感光细胞凋亡,则是视网膜疾病导致患者盲的共同原因,该过程伴有氧化应激和合成代谢的改变。近期研究发现,糖代谢的重要分支--磷酸戊糖途径,在上述病理发展中起重要作用。其产物烟酰胺腺 ...

作者: LIU YunQing1,2,QIN ChengJin1,2,LIU JinLei1,2,JIN YanRui1,2,LI ZhiYuan1,2,ZHAO LiQun,LIU ChengLiang1,21School of Mechanical Engineering,Shanghai Jiao Tong University;2Key Lab of Artificial Intelligence(Ministry of Education),AI Institute,Shanghai Jiao Tong University;3Department of Cardiology,Shanghai First People’s Hospital Affiliated to Shanghai Jiao Tong University)

出处: Science China(Technological Sciences) 2024

摘要: Although 12-lead electrocardiograms(ECGs) provide a wide range of spatiotemporal characteristics, interpreting them for arrhythmia detection is diffic ...

作者: 尹佳宁1,管晓敏2,贾登帅1,徐玲1,陈兰31上海交通大学护理学院;2上海市第一人民医院胸外科;3上海市第一人民医院护理部)

出处: 中华护理杂志 2024

关键词: 重症监护病房;机械通气;撤机;呼吸肌训练;循证护理学

摘要: 目的 提炼并总结ICU机械通气患者撤机后呼吸肌训练的最佳证据,为临床机械通气患者撤机后的呼吸肌训练提供循证依据。方法 系统检索国内外相关指南网站、专业协会网站以及PubMed、Web of Science、Embase、CINAHL、中国知网、维普数据库、万方数据库等关于机械通气患者撤机后呼吸肌训练 ...

作者: 台瑞1,方芳1,杨富2,余倩31上海市第一人民医院护理部;2上海市第一人民医院重症监护室;3上海交通大学护理学院)

出处: 中华护理杂志 2024

关键词: 预康复;胃肠道手术;证据总结;循证护理学

摘要: 目的 检索、评价并总结择期胃肠道手术患者预康复的最佳证据,为临床应用提供参考。方法 计算机检索UpToDate、澳大利亚乔安娜布里格斯研究所循证卫生保健中心数据库、PubMed、CINAHL、Cochrane Library、中国知网、中国生物医学文献数据库、万方数据库和美国国立指南库、苏格兰校际指 ...

作者: Wenmei Han,Wenli Wang,Jie Fan,Runping Jia,Xuchun Yang,Tong Wu,Qingsheng Wu (School of Chemical Science and Engineering, Shanghai Key Laboratory of Chemical Assessment and Sustainability, Institute of Advanced Study, Tongji University;College of Textile and Clothing EngineeringChina National Textile and Apparel Council Key Laboratory of Natural DyesSoochow University;Department of Urology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiaotong University;School of Materials Science and Engineering, Shanghai Institute of Technology)

出处: Green Energy & Environment 2024

关键词: Ag/ZnO hollow Core-shell structures;Antibiotics;Gentamycin;Synergistic sterilization;Photodegradation

摘要: The massive use of antibiotics has led to the aggravation of bacterial resistance and also brought environmental pollution problems.This poses a great ...

作者: 罗政杰1,赵学斌2,周敏1,2,邹景橙2,肖希勉2,刘龙强2,谢佳洋2,武月铭2,张雯静3,刘润辉1,21State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology;2Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Key Laboratory for Ultrafine Materials of Ministry of Education,Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology;3Department of Orthopedic Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University)

出处: Science China(Materials) 2024

摘要: 临床上常用的广谱抗生素无法有效解决抗生素高度耐药ESKAPE菌感染的难题, ESKAPE耐药菌已经成为人类生命健康的重大威胁.抗生素与佐剂的联合治疗是解决抗生素耐药菌感染的重要途径,但是探索对所有ESKAPE耐药菌都具有广谱和高效抗菌活性的抗生素-佐剂组合仍然面临巨大挑战.在这里,我们提出了一种抗生 ...

作者: 吴捷1,李梦瑶2,闫德修3,章雅青1,张媛媛11上海交通大学护理学院;2香港大学护理学院;3上海交通大学附属第一人民医院护理部)

出处: 中华护理教育 2024

关键词: 在职培训;新入职护士;慕课;德尔菲法;头脑风暴法

摘要: 目的 探讨新入职护士基本理论知识培训慕课的开发及其应用效果。方法 根据《新入职护士培训大纲(试行)》和上海交通大学医学院附属13所医院新入职护士培训方案,结合头脑风暴法及应用德尔菲法对13名专家进行2轮函询,初步拟定慕课培训方案。随后邀请16名护理专家撰写慕课脚本和拍摄视频,最终形成新入职护士基本理 ...

作者: Xinyuan Xu1,2,Qian Zhang1,2,Xufeng Wang3,Jing Jin4,Chengwei Wu1,2,Li Feng1,2,5,Xiuyan Yang1,Mingzhu Zhao1,5,Yingyi Chen1,Shaoyong Lu1,Zhen Zheng1,Xiaobing Lan6,Yi Wang4,Yan Zheng7,Xuefeng Lu5,Qiufen Zhang1,Jian Zhang1,21State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine;2Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine;3Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University;4Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medicine and Medical Center, University of Science and Technology of China;5Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine;6College of Pharmacy, Ningxia Medical University;7Department of Pancreatic Surgery, Shanghai General Hospital, Shanghai Key Laboratory of Pancreatic Disease,Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine;8Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine)

出处: Acta Pharmaceutica Sinica B 2024

摘要: Pancreatic cancer, one of the most aggressive malignancies, has no effective treatment due to the lack of targets and drugs related to tumour metastas ...

作者: 王菁菁,李凯,项凯迪,陈军,杜林琳,杨金柳行,刘思辰,汪玲,何鲜桂 (上海市眼病防治中心 同济大学附属眼科医院 国家眼部疾病临床医学研究中心 上海市视觉健康中心(儿童青少年近视防治技术中心);复旦大学公共卫生学院;上海市第一人民医院眼科)

出处: 中华实验眼科杂志 2024

关键词: 近视;光照;豚鼠;多巴胺转运蛋白

摘要: 目的:观察不同光照模式对豚鼠眼内多巴胺转运蛋白(DAT)表达的影响。方法:选取36只白色3周龄普通级豚鼠,采用随机数字表法将其随机分为10 000 lx组、5 000 lx组和500 lx组,每组12只,分别接受相应强度的强光、中强光和正常光照射,并在各组内随机分成3个亚组,每组4只,500 lx组 ...

作者: (Department of Andrology,Center for Men's Health,Urologic Medical Center,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;State Key Lab of Reproductive Medicine,Nanjing Medical University,Nanjing 211166,China;Shanghai Key Lab of Reproductive Medicine,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Department of Andrology,Center for Men's Health,Urologic Medical Center,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Shanghai Key Lab of Reproductive Medicine,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Department of Urology,Guangdong Provincial Key Laboratory of Biomedical Imaging,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai 519000,China;Department of Urology,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

出处: 亚洲男性学杂志(英文版) 2024

关键词: cell proliferation;ORC6;scRNA-seq analysis;spermatogonia;Wnt/β-catenin signaling

摘要: The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining spermatogenesis.The single-cell RNA sequencing(s ...

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