作者： Xinyuan Xu^1,2，Qian Zhang^1,2，Xufeng Wang³，Jing Jin⁴，Chengwei Wu^1,2，Li Feng^1,2,5，Xiuyan Yang¹，Mingzhu Zhao^1,5，Yingyi Chen¹，Shaoyong Lu¹，Zhen Zheng¹，Xiaobing Lan⁶，Yi Wang⁴，Yan Zheng⁷，Xuefeng Lu⁵，Qiufen Zhang¹，Jian Zhang^1,2 （¹State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai,Ruijin Hospital, Shanghai Jiao Tong University School of Medicine；²Medicinal Chemistry and Bioinformatics Center, Shanghai Jiao Tong University School of Medicine；³Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University；⁴Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medicine and Medical Center, University of Science and Technology of China；⁵Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine；⁶College of Pharmacy, Ningxia Medical University；⁷Department of Pancreatic Surgery, Shanghai General Hospital, Shanghai Key Laboratory of Pancreatic Disease,Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine；⁸Department of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine）

出处： Acta Pharmaceutica Sinica B 2024

摘要： Pancreatic cancer, one of the most aggressive malignancies, has no effective treatment due to the lack of targets and drugs related to tumour metastas ...

作者： 王菁菁，李凯，项凯迪，陈军，杜林琳，杨金柳行，刘思辰，汪玲，何鲜桂 （上海市眼病防治中心 同济大学附属眼科医院 国家眼部疾病临床医学研究中心 上海市视觉健康中心（儿童青少年近视防治技术中心）；复旦大学公共卫生学院；上海市第一人民医院眼科）

出处： 中华实验眼科杂志 2024

关键词： 近视；光照；豚鼠；多巴胺转运蛋白

摘要： 目的:观察不同光照模式对豚鼠眼内多巴胺转运蛋白(DAT)表达的影响。方法:选取36只白色3周龄普通级豚鼠，采用随机数字表法将其随机分为10 000 lx组、5 000 lx组和500 lx组，每组12只，分别接受相应强度的强光、中强光和正常光照射，并在各组内随机分成3个亚组，每组4只，500 lx组 ...

作者： （Department of Andrology，Center for Men's Health，Urologic Medical Center，Shanghai General Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200080，China；State Key Lab of Reproductive Medicine，Nanjing Medical University，Nanjing 211166，China；Shanghai Key Lab of Reproductive Medicine，Shanghai Jiao Tong University School of Medicine，Shanghai 200080，China；Department of Andrology，Center for Men's Health，Urologic Medical Center，Shanghai General Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200080，China；Shanghai Key Lab of Reproductive Medicine，Shanghai Jiao Tong University School of Medicine，Shanghai 200080，China；Department of Urology，Guangdong Provincial Key Laboratory of Biomedical Imaging，The Fifth Affiliated Hospital，Sun Yat-sen University，Zhuhai 519000，China；Department of Urology，First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，China）

出处： 亚洲男性学杂志(英文版) 2024

关键词： cell proliferation；ORC6；scRNA-seq analysis；spermatogonia；Wnt/β-catenin signaling

摘要： The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining spermatogenesis.The single-cell RNA sequencing(s ...

作者： Xinyu Yang^1,2，Runhan Li²，Xindi Yang³，Yong Zhou⁴，Yi Liu³，Jing-Dong J.Han² （¹School of Life Sciences,Peking University；²Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Center for Quantitative Biology(CQB),Peking University；³Beijing Key Lab of Traffic Data Analysis and Mining,School of Computer and Information Technology,Beijing Jiaotong University；⁴Clinical Research Institute,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine）

出处： Science China(Life Sciences) 2024

摘要： The human face is a valuable biomarker of aging, but the collection and use of its image raise significant privacy concerns. Here we present an approa ...

作者： Hua Sui，Wanli Deng，Qiong Chai，Bing Han，Yuli Zhang，Zhenzhen Wei，Zan Li，Ting Wang，Jiling Feng，Man Yuan，Qingfeng Tang，Hongxi Xu （Medical Experiment Center, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine；Translational Medicine Research Center for Cancer Prevention and Treatment,Shanghai General Hospital Jiading Branch-School of Pharmacy of Shanghai University of Traditional Chinese Medicine Joint Laboratory；Department of Medical Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine；School of Pharmacy, Shanghai University of Traditional Chinese Medicine；The Second Clinical Medical College of Henan University of Traditional Chinese Medicine；Shanghai University of Traditional Chinese Medicine；Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine）

出处： Journal of Pharmaceutical Analysis 2024

关键词： Tumor；microenvironment Intestinal；epithelial；cells；Treg/Th17；cells；Metabolism；Wnt5a/JNK；signaling；Tumorigenesis

摘要： The density and composition of lymphocytes infiltrating colon tumors serve as predictive factors for the clinical outcome of colon cancer.Our previous ...

作者： 段晓磊¹，曹文婷²，林琪³，周意¹，陈兰⁴，方芳⁴ （¹上海市第一人民医院泌尿外科；²上海市健康医学院护理与健康管理学院；³上海市第六人民医院护理部；⁴上海市第一人民医院护理部）

出处： 护理管理杂志 2024

关键词： 前列腺癌；患者；需求；应对；焦虑；抑郁

摘要： 目的 调查机器人辅助前列腺癌根治术后患者支持性照护未满足需求现状，分析其影响因素。方法 采用一般资料调查表、癌症患者未满足需求简明量表、医学应对方式问卷、医院焦虑抑郁量表对上海市某三级甲等综合性医院的248例机器人辅助腹腔镜前列腺癌根治术后患者进行调查。结果 患者术后未满足照护需求得分为（61.96 ...

作者： 周健¹，沈永红¹，方芳²，王瑞平³，姚蓉¹，荣丽媛¹，张瑞萍¹，陆静波¹ （¹上海中医药大学附属岳阳中西医结合医院护理部；²上海市第一人民医院护理部；³同济大学附属皮肤病医院临床研究中心）

出处： 护理管理杂志 2024

关键词： 结直肠癌；脾虚证；中医护理方案；肠功能

摘要： 目的 探讨中医护理方案对结直肠癌术后脾虚证患者肠功能恢复的影响。方法 便利选取上海市某三级甲等中西医结合医院胃肠外科住院的224例患者作为研究对象，采用非同期前后对照研究分为对照组（n=109）和试验组（n=115）。对照组采用快速康复护理联合中医常规护理，试验组在此基础上实施脾虚证患者肠功能恢复中 ...

作者： Huan Wu^1,2,3，Yanman Zhang⁴，Yuqian Li¹，Shuya Sun⁴，Jintao Zhang⁵，Qingsong Xie¹，Yue Dong⁴，Shushu Zhou^1,6,7，Xuan Sha¹，Kuokuo Li^1,6,7，Jinyi Chen⁴，Xin Zhang⁴，Yang Gao^1,6,7，Qunshan Shen^1,6,7，Guanxiong Wang¹，Xiaomin Zha^1,2,3，Zongliu Duan^1,2,3，Dongdong Tang^1,2,3，Chuan Xu^1,2,3，Hao Geng^1,2,3，Mingrong Lv^1,6,7，Yuping Xu^1,6,7，Ping Zhou^1,6,7，Zhaolian Wei^1,6,7，Rong Hua^1,2,3,6，Yunxia Cao^1,2,3，Mingxi Liu⁸，Xiaojin He^9,2 （¹Reproductive Medicine Center,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University；²NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University)；³Key Laboratory of Population Health Across Life Cycle (Anhui Medical University),Ministry of Education of the People's Republic of China；⁴State Key Laboratory of Reproductive Medicine and Offspring Health,Department of Histology and Embryology,School of Basic Medical Sciences,Nanjing Medical University；⁵State Key Laboratory of Reproductive Medicine and Offspring Health,Clinical Center of Reproductive Medicine,The First Affiliated Hospital of Nanjing Medical University；⁶Anhui Province Key Laboratory of Reproductive Health and Genetics；⁷Biopreservation and Artificial Organs,Anhui Provincial Engineering Research Center,Anhui Medical University；⁸State Key Laboratory of Reproductive Medicine and Offspring Health,The Affiliated Taizhou People's Hospital of Nanjing Medical University,Taizhou School of Clinical Medicine,Nanjing Medical University；⁹Reproductive Medicine Center,Department of Obstetrics and Gynecology,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine）

出处： Science China(Life Sciences) 2024

摘要： The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate signific ...

作者： 江浩¹，吴冠文¹，黄威²，李小兵¹，范江² （¹绍兴市中心医院 绍兴文理学院附属中心医院心胸外科, 绍兴；²上海交通大学附属第一人民医院胸外科, 上海）

出处： 中华胸心血管外科杂志 2024

摘要： 胸壁肿瘤(chest wall tumor, CWT)是一类异质性明显的肿瘤, 涉及多个系统, 包括原发性和继发性。胸壁肿瘤可以按照组织学来源进行分类, 并区分良恶性。除极少数恶性肿瘤外, 手术切除是胸壁肿瘤的首选治疗方法。相对于其他肿瘤, 很多胸壁肿瘤切除后会使胸壁失去完整性及稳定性, 因此术前不 ...

作者： 武秀梅¹，张红爱²，闫燕¹，陈晨¹ （¹西安交通大学附属西安市儿童医院新生儿科, 西安；²上海市第一人民医院儿科, 上海）

出处： 中华新生儿科杂志(中英文) 2024

关键词： 极长链酰基辅酶A脱氢酶缺乏症；脂质沉积性肌病；横纹肌溶解；新生儿

摘要： 本文报道1例以呻吟、纳差、酱油尿起病, 病初诊断为脂质沉积性肌病, 后经基因检测确诊新生儿肌病型极长链酰基辅酶A脱氢酶缺乏症的患儿, 以加强临床医师对此类疾病的认识。