发明人： 王枫，刘振国，赵永波

申请人： 上海市第一人民医院，潍坊市人民医院

申请号： 201110084474.5

申请日期： 2011.04.02

摘要： 本发明属生物医药领域，涉及一种靶向治疗难治性癫痫的药物组合物，本发明的药物组合物含小分子化合物或单克隆抗体或携带小分子干扰RNA的病毒载体，此组合物中的小分子化合物或单克隆抗体或携带小分子干扰RNA的病毒载体的有效剂量为对P-糖蛋白的表达抑制效率达到30％及以上时的量，动物实验结果显示，该有效剂量能 ...

发明人： 王枫，刘振国，赵永波

申请人： 上海市第一人民医院，潍坊市人民医院

申请号： 201110084443.X

申请日期： 2011.04.02

摘要： 本发明属生物医药领域，涉及药物筛选的方法，具体涉及一种筛选敏感型难治性癫痫药物的方法。本发明通过建立能够出现反复自发性痫性发作的癫痫动物模型，通过给予癫痫动物模型抗癫痫药物筛选出药物敏感型和药物抵抗型亚组，根据相关危险性因子的表达差异，筛选敏感型难治性癫痫药物。本发明为解决目前临床应用中出现的难治性 ...

作者： Wang, Feng;Li, Hui-Ming;Wang, Hui-Ping;Ma, Jia-Lie;Chen, Xia-Fang;Wei, Fang;Yi, Miao-Ying;Huang, Qian

出处： EXPERIMENTAL AND THERAPEUTIC MEDICINE 2010 Vol.1 No.5 P899-904

摘要： The growth of solid tumors is highly dependent on the formation of new blood and/or lymph vessels. Furthermore, metastases often disperse via newly fo ...

发明人： FENG WANG;ZHENGUO LIU;YONGBO ZHAO

申请人： SHANGHAI FIRST PEOPLE S HOSPITAL;WEIFANG PEOPLE S HOSPITAL

申请号： CN2011100844745

申请日期： 2011.04.02

摘要： The invention belongs to the biological medicine field, and relates to a pharmaceutical composition for targeting treatment of intractable epilepsy, t ...

发明人： FENG WANG;ZHENGUO LIU;YONGBO ZHAO

申请人： SHANGHAI FIRST PEOPLE S HOSPITAL;WEIFANG PEOPLE S HOSPITAL

申请号： CN201110084443X

申请日期： 2011.04.02

摘要： The invention belongs to the biological medicine field, and relates to a method for screening medicines, and concretely relates to a method for screen ...

作者： Chen, Cong-Ying;Shen, Jia-Qing;Wang, Feng;Wan, Rong;Wang, Xing-Peng

出处： ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 2012 Vol.13 No.9 P4707-4712

摘要： Annexin A1 is a 37-kDa calcium-and phospholipid-binding protein of the annexin superfamily considered to play an important role in tumorigenesis. Howe ...

作者： Wang, Huiping;Wei, Fang;Zhang, Jufeng;Wang, Feng;Li, Huiming;Chen, Xiafang;Xie, Kuangcheng;Wang, Yufei;Li, Chuanyuan;Huang, Qian

出处： TUMOR BIOLOGY 2012 Vol.33 No.4 P1245-1253

摘要： Low gene transfer rate in tumors, high dose-induced acute inflammatory response, and lack of an immunocompetent preclinical animal model to accurately ...

作者： Lv, Rilang;Xu, Xiaoyun;Luo, Zheng;Shen, Nan;Wang, Feng;Zhao, Yongbo

出处： EXPERIMENTAL AND THERAPEUTIC MEDICINE 2014 Vol.7 No.1 P39-45

摘要： The aim of this study was to investigate the effects of pyrrolidine dithiocarbamate (PDTC) on MCP-1 expression and microglial activation in the hippoc ...

作者： Lu, Haiyan;Song, Xiaoyan;Wang, Feng;Wang, Guodong;Wu, Yuncheng;Wang, Qiaoshu;Wang, Yongting;Yang, Guo-Yuan;Zhang, Zhijun

出处： FRONTIERS IN CELLULAR NEUROSCIENCE 2016 Vol.10

摘要： Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral i ...

作者： Liu, Zanhua;Wang, Suping;Liu, Jinjie;Wang, Feng;Liu, Yi;Zhao, Yongbo

出处： INFLAMMATION 2016 Vol.39 No.3 P1090-1098

摘要： Epilepsy, which affects about 1 % of the population worldwide, leads to poor prognosis and increased morbidity. However, effective drugs providing sat ...