【卷号】SHANGHAI FIRST PEOPLE S HOSPITAL;WEIFANG PEOPLE S HOSPITAL
【页码】2012.10.17
【ISSN】CN2011100844745
【分类号】A61K45/00
【摘要】The invention belongs to the biological medicine field, and relates to a pharmaceutical composition for targeting treatment of intractable epilepsy, the pharmaceutical composition of the present invention contains a micromolecule compound or a monoclonal antibody or virus vector carrying micromolecule interference RNA, the effective dosage of the micromolecule compound or the monoclonal antibody or the viral vector carrying micromolecule interference RNA in the composition on the P-glycoprotein expression inhibition efficiency can reach 30% or more than 30%, the animal experiment result shows that the effective dosage can perform the effects for inhibiting the epilepsy attack frequency and the attack duration. The corresponding brain wave presents the similar change with the epilepsy attack frequency and the attack duration.
