作者： Ying Peng  ¹, Zhuoxuan Li  ¹, Zhiyang Zhang  ², Yinglun Chen  ³, Renyuan Wang  ¹, Nixi Xu  ², Yuanwu Cao  ², Chang Jiang  ², Zixian Chen  ², Haodong Lin  ¹ （Affiliations ¹ Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China. ³ Department of Rehabilitation Medicine, Shanghai Geriatric Medical Center, Shanghai, China.）

出处： Neural regeneration research 2024

关键词： bromocriptine;central nervous system;cytosolic phospholipase A2;high-content screening;lipid droplet;lipid metabolism;lipotoxicity;mitogen-activated protein kinase;spinal cord injury;spinal cord neurons.

摘要： Recent studies have revealed that lipid droplets accumulate in neurons after brain injury and evoke lipotoxicity, damaging the neurons. However, how l ...

作者： Hengxing Zhou  ¹, Yongfu Lou  ², Lingxiao Chen  ³, Yi Kang  ⁴, Lu Liu  ⁵, Zhiwei Cai  ⁶, David B Anderson  ⁷, Wei Wang  ⁸, Chi Zhang  ⁸, Jinghua Wang  ⁹, Guangzhi Ning  ⁴, Yanzheng Gao  ¹⁰, Baorong He  ⁵, Wenyuan Ding  ¹¹, Yisheng Wang  ¹², Wei Mei  ¹³, Yueming Song  ¹⁴, Yue Zhou  ¹⁵, Maosheng Xia  ¹⁶, Huan Wang  ¹⁷, Jie Zhao  ¹⁸, Guoyong Yin  ¹⁹, Tao Zhang  ²⁰, Feng Jing  ²¹, Rusen Zhu  ²², Bin Meng  ²³, Li Duan  ²⁴, Zhongmin Zhang  ²⁵, Desheng Wu  ²⁶, Zhengdong Cai  ²⁷, Lin Huang  ²⁸, Zhanhai Yin  ²⁹, Kainan Li  ³⁰, Shibao Lu  ³¹, Shiqing Feng  ³² （Affiliations ¹ Department of Orthopedics, The Second Hospital, Cheeloo College of Medicine; Department of Orthopedics, Shandong University Center for Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China. ² Department of Orthopedics, The Second Hospital, Cheeloo College of Medicine, Shandong University, Shandong; Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China. ³ Department of Orthopedics, Shandong University Center for Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China; Faculty of Medicine and Health, The Back Pain Research Team, Sydney Musculoskeletal Health, The Kolling Institute, University of Sydney, Sydney, NSW, Australia. ⁴ Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China. ⁵ Department of Spine Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. ⁶ Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, China. ⁷ Faculty of Medicine and Health, School of Health Sciences, University of Sydney; Sydney Spine Institute, Burwood, Sydney, NSW, Australia. ⁸ Department of Orthopedics, Shandong University Center for Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong, China. ⁹ Laboratory of Epidemiology, Tianjin Neurological Institute, Department of Neurology, Tianjin Medical University General Hospital & Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China. ¹⁰ Department of Orthopedics, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China. ¹¹ Department of Spinal Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China. ¹² Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China. ¹³ Department of Spine Surgery, Zhengzhou Orthopedics Hospital, Zhengzhou, Henan Province, China. ¹⁴ Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. ¹⁵ Department of Orthopedics, Xinqiao Hospital, Army Medical University, Chongqing, China. ¹⁶ Department of Orthopedics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China. ¹⁷ Department of Spinal Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China. ¹⁸ Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁹ Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. ²⁰ Department of Spinal Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. ²¹ Department of Spinal Surgery, Tianjin Hospital, Tianjin, China. ²² Department of Spine Surgery, Tianjin Union Medical Center, Tianjin, China. ²³ Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China. ²⁴ Department of Orthopedics, Shenzhen Intelligent Orthopedics and Biomedical Innovation Platform, Guangdong Artificial Intelligence Biomedical Innovation Platform, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong Province, China. ²⁵ Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong Province, China. ²⁶ Department of Spine Surgery, Shanghai East Hospital Affiliated to Tongji University School of Medicine, Shanghai, China. ²⁷ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ²⁸ Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China. ²⁹ Department of Orthopedics, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. ³⁰ Department of Orthopedic Surgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan Province, China. ³¹ Department of Orthopedics, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China; National Geriatric Diseases Research Center, Beijing, China. ³² Department of Orthopedics, The Second Hospital, Cheeloo College of Medicine; Department of Orthopedics, Shandong University Center for Orthopedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Shandong; Department of Orthopedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury, Tianjin Key Laboratory of Spine and Spinal Cord, Tianjin, China.）

出处： Neural regeneration research 2024

关键词： China;clinical features;costs;epidemiology;methylprednisolone;methylprednisolone sodium succinate;retrospective study;traumatic spinal cord injury;treatment.

摘要： Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death. China has the largest population of patie ...

作者： Tianjiao Guo^1,2,31;Jie Yang²CA2;Qi Yu^4,5,6CA3 （¹Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai, China;²Institute of Image Processing and Pattern Recognition, Department of Automation, Shanghai Jiao Tong University, Shanghai, China;³School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China;⁴Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁵National Clinical Research Center for Eye Diseases, Shanghai, China;⁶Shanghai Clinical Research Center for Eye Diseases, Shanghai, China）

出处： Biomedical Signal Processing and Control 2024

摘要： The segmentation of diabetic retinopathy (DR) lesions is important for large-scale screening using color fundus photography (CFP) images. The difficul ...

作者： Yanrui Jin¹;Zhiyuan Li¹;Chengjin Qin¹CA1;Jinlei Liu¹;Yunqing Liu¹;Liqun Zhao²;Chengliang Liu¹CA2 （¹State Key Laboratory of Mechanical System and Vibration, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;²Department of Cardiology, Shanghai First People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, China）

出处： Biomedical Signal Processing and Control 2023

关键词： Attention mechanism;Convolution neural network;ECG quality assessment;Long short-term memory neural network

摘要： ECG quality assessment is of great significance to reduce false alarms in automatic arrhythmia and other cardiovascular diseases diagnoses and reduce ...

作者： lei tang，guo-tong xu，jing-fa zhang （Department of Ophthalmology of Tongji Hospital Tongji Eye Institute Department of Regenerative Medicine and Department of Pharmacology Tongji University School of Medicine Shanghai China Department of Ophthalmology of Tongji Hospital Tongji Eye Institute Department of Regenerative Medicine and Department of Pharmacology Tongji University School of Medicine Shanghai China；Department of Ophthalmology Shanghai General Hospital (Shanghai First People’s Hospital) Shanghai Jiao Tong University Shanghai China Department of Ophthalmology Shanghai General Hospital (Shanghai First People’s Hospital) Shanghai Jiao Tong University Shanghai China；National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai Engineering Center for Visual Science and Photomedicine Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases Shanghai China National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai Engineering Center for Visual Science and Photomedicine Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases Shanghai China）

出处： Neural Regeneration Research 2023

关键词： anti-inflammation；therapy；anti-vascular；endothelial；growth；factor；diabetic；retinopathy；hyperreflectivity；foci；inflammation；inflammatory；cells；inflammatory；cytokines；leukostasis；microglia；Müller；cells

摘要： Diabetic retinopathy, characterized as a microangiopathy and neurodegenerative disease, is the leading cause of visual impairment in diabetic patients ...

作者： Lei Tang  ¹, Guo-Tong Xu  ¹, Jing-Fa Zhang  ² （Affiliations ¹ Department of Ophthalmology of Tongji Hospital, Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University; National Clinical Research Center for Eye Diseases; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.）

出处： Neural regeneration research 2023

关键词： Müller cells;anti-inflammation therapy;anti-vascular endothelial growth factor;diabetic retinopathy;hyperreflectivity foci;inflammation;inflammatory cells;inflammatory cytokines;leukostasis;microglia.

摘要： Diabetic retinopathy, characterized as a microangiopathy and neurodegenerative disease, is the leading cause of visual impairment in diabetic patients ...

作者： 唐智，郎蕾，王任远，顾松 （东华大学机械工程学院；上海市第一人民医院创伤临床医学中心）

出处： 中国组织工程研究 2023

关键词： 拇外翻；有限元模型；生物力学分析；第1跖趾关节角；第1跖骨

摘要： 背景：有限元模型构建及生物力学分析使探究拇外翻足的形成及相关结构功能恢复成为可能。目的：建立负重中立位中度拇外翻足有限元模型，分析不同部位及大小的外力作用下第1跖趾关节角度的变化与对应骨骼应力分布情况。方法：选取1名女性中度拇外翻志愿者，采集CT影像数据，利用计算机三维成像技术进行三维有限元建模，验 ...

作者： Chao Zhong^1,2;Yueming Wu^1,2;Haodong Lin^3,4CA1;Runhui Liu^1,5,6CA2 （¹State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China;²C. Z. and Y. W. have equally contributed to the manuscript.;³Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;⁴Jiading Branch of Shanghai General Hospital, Shanghai, 201803, China;⁵Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism, Research Center for Biomedical Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China;⁶East China University of Science and Technology Shenzhen Research Institute, Shenzhen 518063, China）

出处： Composites Part B: Engineering 2023

摘要： Osteomyelitis is a major complication of orthopedic diseases with high recurrence and morbidity, along with long hospital stays and high medical costs ...

作者： Dan-Dan Liu¹，Chao-Yang Zhang^2,3，Jing-Ting Zhang^2,3，Li-Min Gu⁴，Guo-Tong Xu¹，Jing-Fa Zhang^2,3 （¹Department of Ophthalmology of Tongji Hospital, Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine；²Department of Ophthalmology, Shanghai General HospitalShanghai First People's Hospital, Shanghai Jiao Tong University；³National Clinical Research Center for Eye Diseases,Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases；⁴Department of Ophthalmology, Shanghai Aier Eye Hospital）

出处： Neural Regeneration Research 2023

关键词： diabetic；retinopathy；DNA；methylation；epigenetics；histone；modification；metabolic；memory；M⁶A；modification；non-coding；RNAs；review

摘要： Epigenetics focuses on DNA methylation, histone modification, chromatin remodeling, noncoding RNAs, and other gene regulation mechanisms beyond the DN ...

作者： Chong Chen  ¹, Guangyi Hu, Feng'e Chen, Kun Liu, Suqin Yu, Xun Xu （Affiliation ¹ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.）

出处： Retina (Philadelphia, Pa.) 2023

摘要： Carbon fiber microelectrodes and carbon fiber composite minielectrodes (CFM/CFCM) have been generally used for measurements of nitric oxide (NO) conce ...