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作者: Xiue Ma 1, Liming Gao 2, Rucun Ge 3, Tianyou Yuan 4, Bowen Lin 5, Lixiao Zhen 6 (Affiliations 1 School of Medicine, Tongji University, Shanghai, 200092, China. 2 Department of Cardiology, Ji'an Hospital, Shanghai East Hospital, Ji'an, 343000, Jiangxi, China. 3 Shandong Provincial Third Hospital, Shandong University, Jinan, 250012, Shandong, China. 4 Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. tianyou_yuan@163.com. 5 School of Medicine, Tongji University, Shanghai, 200092, China. bowenlin0512@163.com. 6 Shandong Provincial Third Hospital, Shandong University, Jinan, 250012, Shandong, China. zlxiao56@163.com.)
出处: In vitro cellular & developmental biology. Animal 2024
关键词: AKT;CDC-like kinase 3;Cardiomyocyte apoptosis;Hypoxia.
摘要: Hypoxia-induced cardiomyocyte apoptosis is one major pathological change of acute myocardial infarction (AMI), but the underlying mechanism remains un ...
作者: Ximo Xu 1 2, Hao Zhong 1, Jun You 3, Mingyang Ren 4, Abe Fingerhut 1 5, Minhua Zheng 1, Jianwen Li 1, Xiao Yang 1, Haiqin Song 1, Sen Zhang 1, Chengsheng Ding 1, Naijipu Abuduaini 1, Mengqin Yu 1, Jingyi Liu 1, Yi Zhang 1, Liang Kang 6 7, Zhenghao Cai 1, Bo Feng 1 (Affiliations 1 Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai. 3 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen. 4 Department of Gastrointestinal Surgery, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong. 5 Section for Surgical Research, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29, Graz, Austria. 6 Department of General Surgery (Colorectal Surgery). 7 Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.)
出处: International journal of surgery (London, England) 2024
摘要: Background: With the optimization of neoadjuvant treatment regimens, the indications for intersphincteric resection (ISR) have expanded. However, limi ...
作者:
Chen, Yuhonga,b;Chen, Jieqionga,b;Wang, Honga,b;Yu, Yanga;Wang, Wenqiua,b;Liu, Wenjiaa,b;Yu, Suqina,b;Gong, Yuanyuana,b;Jia, Huixuna,b,c;Li, Tonga,b
出处: Eye (Basingstoke) 2024
摘要: Background: To investigate the prevalence of outer retinal tubulation (ORT) and its correlations with optical coherence tomography (OCT) parameters in ...
作者:
Lingzhou Zhao1;Yan Xing1;Changcun Liu1;Shaofei Ma2;Wenhua Huang3;Zhen Cheng4,5
出处: Breast Cancer Research 2024
关键词: HER2;Breast cancer;Nanobody;SPECT/CT imaging;99mTc
摘要: Background 99mTc radiolabeled nanobody NM-02 (99mTc-NM-02) is a novel single photon emission computed tomography (SPECT) probe ...
作者:
Yu Tian1;Li Wang2;Yunyun Qian3;Ling Li1;Hao Li3
出处: ACS Materials Letters 2024
摘要: The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains a significant challenge. T ...
作者:
Hui-Yi Li1;Yu-Xuan Gao1;Jun-Cheng Wu3;Jing-Ze Li4;Seng-Wang Fu2
出处: Cell & Bioscience 2024
关键词: Non-alcoholic steatohepatitis (NASH);Liver sinusoidal endothelial cell (LSEC);Single-cell RNA sequencing (scRNA-seq);KIT proto-oncogene receptor tyrosine kinase (C-Kit);Mitophagy
摘要: Aim To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH). Methods We profiled single-LSEC fr ...
作者:
Yingying Liao1;Jiahui Ye1;Luoyijun Xie1;Longfei Mao2;Jiangcun Wei3;Chutong Liu1;Jing Liang3;Jianlong Zhou3
出处: ACS Applied Nano Materials 2024
关键词: nonsmall cell lung cancer;chemo-photodynamic therapy;nanoparticles;d17;Ce6
摘要: The theophylline derivative d17 is a candidate drug for nonsmall cell lung cancer (NSCLC) treatment previously developed by our group. However, it has ...
作者:
Bingxin Xu1;Jindong Yao1;Wenqi Song1;Xinyi Yan1;Ming Zhu1;Jiangtao Li2;Zhonglin Ma2;Yanchuan Li3;Yihao Li3;Yanbin Fu4;Liu Liu5;Lei Li6
出处: ACS Pharmacology & Translational Science 2024
关键词: MC4R;constitutive activity;second intracellular loop
摘要: Melanocortin-4 receptor (MC4R) functions as a crucial neuroendocrine G protein-coupled receptor (GPCR) in the central nervous system of mammals, displ ...
作者: Yung-Chiang Liu61;Ping Chen623;Ray Chang1;Xingjian Liu1;Jhe-Wei Jhang1;Myagmartsend Enkhbat4;Shan Chen1;Hongxia Wang5;Chuxia Deng72;Peng-Yuan Wang71 (1Oujiang Laboratory;Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, Zhejiang 325024, People's Republic of China;2Cancer Centre, Faculty of Health Sciences, MOE Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR 999078, People's Republic of China;3Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, People's Republic of China;4Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada;5State Key Laboratory of Oncogenes and Related Genes, Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China)
出处: Biofabrication 2024
摘要: The tumor microenvironment (TME) is critical for tumor growth and metastasis. The TME contains cancer-associated cells, tumor matrix, and tumor secret ...
作者:
Shuli Chen1,2,3,4;Yi Xu1,3,4;Bo Chen6;Senlin Lin1,3,4
出处: Lipids in Health and Disease 2024
关键词: Diabetic retinopathy;Remnant cholesterol;Retinal vessels;Type 2 diabetes mellitus
摘要: Background The association between remnant cholesterol (RC) and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) remains unclear. Morphol ...
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