作者： Zhixuan Chen;Jieqiong Chen;Min Gao;Yang Liu;Yidong Wu;Yafang Wang;Yuanyuan Gong;Suqin Yu;Wenjia Liu;Xiaoling Wan;Xiaodong Sun （Affiliations ¹ Department of Ophthalmology, School of Medicine, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China. ² Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Department of Ophthalmology, Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. ⁴ Department of Ophthalmology, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.）

出处： Human mutation 0

关键词： Alu-Alu mediated rearrangement;PRPF31;copy number variation;retinitis pigmentosa.

摘要： Retinitis pigmentosa (RP) is a monogenic disease characterized by irreversible degeneration of the retina. PRPF31, the second most common causative ge ...

作者： Yifan Hu;Jieqiong Chen;Yuwei Wang;Junran Sun;Peirong Huang;Jingyang Feng;Te Liu;Xiaodong Sun （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), National Clinical Research Center for Ophthalmic Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. ² Department of Ophthalmology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, and Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China. ⁴ Central Laboratory, Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.）

出处： Cell biology international 0

关键词： N6-methyladenosine;age-related macular degeneration;amyloid-β;fat mass and obesity-associated protein;m6A-mRNA epi-transcriptomic microarray;retinal pigment epithelium.

摘要： Amyloid-β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD ...

作者： Chaoyang Zhang;Dawei Luo;Hai Xie;Qian Yang;Dandan Liu;Lei Tang;Jingting Zhang;Weiye Li;Haibin Tian;Lixia Lu;Xiaodong Sun;Guo-Tong Xu;Jingfa Zhang （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China; Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ³ Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. ⁴ Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China; Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, United States. ⁵ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: xdsun@sjtu.edu.cn. ⁶ Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. Electronic address: gtxu@tongji.edu.cn. ⁷ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China; Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. Electronic address: 13917311571@139.com.）

出处： Pharmacological research 0

关键词： Aquaporin 11;Diabetic macular edema;Diabetic retinopathy;MicroRNAs;Müller intracellular edema;Na(+)-K(+)-ATPase.

摘要： Retinal Müller glial dysfunction and intracellular edema are important mechanisms leading to diabetic macular edema (DME). Aquaporin 11 (AQP11) is pri ...

作者： Yue Wang;Qianqian Xue;Qiang Zheng;Yan Jin;Xuxia Shen;Mu Yang;Xiaoyan Zhou;Yuan Li （Affiliations ¹ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. ² Department of Pathology, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, 200032, Shanghai, China. Electronic address: yangmu1021@hotmail.com. ³ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: whliyuan@hotmail.com.）

出处： Laboratory investigation; a journal of technical methods and pathology 0

摘要： SMAD4 is an intracellular signaling mediator of the TGF-β pathway. Its mutation was commonly observed in gastrointestinal cancers, such as pancreatic ...

作者： Zhongmao Fu;Pengshan Zhang;Renchao Zhang;Bimeng Zhang;Shijun Xiang;Yuan Zhang;Zai Luo;Chen Huang （Affiliations ¹ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Acupuncture-Moxibustion, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. richard-hc@sohu.com.）

出处： Oncogene 0

摘要： Tumor hypoxia and circular RNAs (circRNAs) are considered to play key roles in tumor progression and malignancy, respectively. Nevertheless, the biolo ...

作者： Qi Zhu;Desheng Chen;Yichao Lou;Xueqian Xie;Yi Wu;Zhaowen Wang;Hongcheng Sun （Affiliations ¹ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. sunhongchengmd@163.com.）

出处： Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 0

关键词： Cirrhosis;Cirrhosis regression;Health-related quality of life;Hypersplenism;Splenectomy.

摘要： Purpose: Splenectomy is an effective treatment for correcting cytopenia caused by hypersplenism secondary to cirrhosis. However, other potential benef ...

作者： Lei Chen;Ming-Lei Sha;Fei-Teng Chen;Chen-Yi Jiang;Deng Li;Chao-Liang Xu;De-Shen Pan;Zi-Jie Xu;Qi-Lin Tang;Shu-Jie Xia;Lian-Hui Sun;Guang-Jian Fan;Yi Shao （Affiliations ¹ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, China. ² Department of Geriatric, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Laboratory of Cancer Genomics and Biology, Department of Urology, And Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁴ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: lhsun@sjtu.edu.cn. ⁵ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: gjfan@shsmu.edu.cn. ⁶ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, China. Electronic address: drshaoyi@163.com.）

出处： Free radical biology & medicine 0

关键词： Fatty acid oxidation (FAO);KLF14;PPARα;Renal fibrosis.

摘要： Tubulointerstitial fibrosis (TIF) is essential during the development of end-stage kidney disease (ESKD) and is associated with the impairment of fatt ...

作者： Dongyao Zhang;Jing Sheng;Li Chen;Decui Cheng;Yannan Cao;Yao Su;Ying Jiang;Wenyu Liu;Yuexin Yu;Haoyi Jia;Pengyuan He;Li Wang;Xianming Xu （Affiliations ¹ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. ² Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. ³ Nursing Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.）

出处： Molecular nutrition & food research 0

关键词： advanced maternal age;dietary fiber;gestational diabetes mellitus;gestational weight gain;glucose metabolism.

摘要： Scope: To investigate whether dietary fiber supplementation may reduce the risk of gestational diabetes mellitus (GDM) in advanced maternal age Chines ...

作者： Yanping Lin;Jianhua Huang;Wangjie Xu;Cancan Cui;Wenzhe Xu;Zhaojun Li （Affiliations ¹ School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China. ² Department of Ultrasound, Zibo Central Hospital, Zibo, Shangdong Province, China. ³ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Department of Ultrasound, Shanghai General Hospital Jiading Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: lzj_1975@sina.com.）

出处： Ultrasound in medicine & biology 0

关键词： CSWin transformer;Carotid artery;Medical image segmentation;Ultrasound image.

摘要： Precise segmentation of carotid artery (CA) structure is an important prerequisite for the medical assessment and detection of carotid plaques. For au ...

作者： Qilin Tang;Deshen Pan;Chaoliang Xu;Lei Chen （Affiliations ¹ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100, Haining Road, Shanghai, Hongkou District, 200080, China. ² Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. ³ Laboratory of Cancer Genomics and Biology, Department of Urology, and Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁴ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100, Haining Road, Shanghai, Hongkou District, 200080, China. drchenlei@126.com. ⁵ Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. drchenlei@126.com.）

出处： Journal of cancer research and clinical oncology 0

关键词： Chromatin regulators;Lasso;Molecular subtypes;Papillary renal cell carcinoma;Tumor microenvironment.

摘要： Background: Papillary renal cell carcinoma (pRCC) is the second most common histological type of renal cell carcinoma. The prognosis of local pRCC is ...