作者： Na Sun;Wenli Qiao;Yan Xing;Taisong Wang & Jinhua Zhao （¹Department of Nuclear Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200080, China）

出处： Annals of Hematology

关键词： ¹⁸F-FDG;PET/CT;Follicular lymphoma;R-CHOP

摘要： Purpose The prognostic value of interim ¹⁸F-FDG PET/CT (I-PET) for follicular lymphoma (FL) is controversial, and may be related to the la ...

作者： Chuanhui Xu;Jun Qin;Jinhui Yu;Yan Sun;Dongmin Hu;Gang Wu & Yang Li （¹Department of Radiology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, 1158 Gongyuan East Road, Qingpu District, Shanghai, 201700, China;²Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Hongkou District, Shanghai, 200080, China）

出处： Neuroradiology

摘要： Synthetic methods for pyrrolinone-based compounds are provided. Such compounds mimic or inhibit the biological and/or chemical activity of peptides.

作者： Chen Kai Huang;Lei Lv;Huanliang Chen;Ying Sun & Yong Ping （¹Department of Molecular and Cellular Biology, University of California, Berkeley, 110 Sproul Hall, Berkeley, CA, 94720, USA;²MOE Key Laboratory of Metabolism and Molecular Medicine, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China;³Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201620, China;⁴Department of Immunology and Microbiology, School of Medicine, Shanghai Jiao Tong University, 280 South Chongqing Road, Shanghai, 200025, China;⁵Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, 200240, China）

出处： Clinical and Translational Oncology

关键词： ENO1;Pancreatic cancer;T_reg;Cytokine;Knockout/Crispr;Tumor immunology

摘要： Background Pancreatic adenocarcinoma (PAAD) is a highly aggressive and malignant cancer type with the highest mortality rate of all major cancers. Ho ...

作者： 盛艾娟¹，王美霞²，刘强³，余中光⁴，陈虎⁵，蒋辉⁶，周吉银⁷，王小琪¹，于海滨¹，訾明杰⁸，江一峰⁹，徐蕾¹⁰，时涛¹¹，孙桂珍¹，郑东翔¹ （¹首都医科大学附属北京佑安医院伦理委员会；²北京积水潭医院临床试验机构；³世界中医药学会联合会评价中心；⁴中日友好医院呼吸中心；⁵沧州市中心医院科研处；⁶福建医科大学附属漳州市医院科教科；⁷陆军军医大学第二附属医院国家药物临床试验机构；⁸中国中医科学院西苑医院；⁹上海交通大学附属第一人民医院伦理办公室；¹⁰大连医科大学附属第一医院伦理办公室；¹¹深圳市第二人民医院伦理委员会）

出处： 中国医学伦理学

关键词： 委托审查；伦理(审查)委员会；委托合同；委托人；受托人；涉及人的生命科学和医学研究；研究参与者

摘要： 通过伦理审查，是涉及人的生命科学和医学研究开展的必要条件和前提条件。目前国内部分医疗卫生机构没有伦理审查能力或者审查能力不足。伦理审查能力的欠缺和不足，成为制约涉及人的生命科学和医学研究开展的瓶颈。《关于深化审评审批制度改革鼓励药品医疗器械创新的意见》《关于加强科技伦理治理的意见》等文件提出，机构可 ...

作者： Yu Zhuang;Di-cheng Yang;Xiao-wei Xi & Yi-zhou Ye （¹Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100# Haining Road, Shanghai, 200080, China;²Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100# Haining Road, Shanghai, 200080, China）

出处： Indian Journal of Surgery

关键词： Leiomyomatosis;Surgical strategy;Uterine leiomyoma;Intracardiac tumor;Bilateral salpingo-oophorectomy

摘要： Intravenous-cardiac leiomyomatosis is an uncommon tumor arising from invasive uterine leiomyomata, with nodular masses extending into the inferior ven ...

作者： Wenlu Niu;Leheng Liu;Xiaowan Wu;Tiancheng Mao;Zhixia Dong;Xinjian Wan;Hui Zhou;Jing Wang （¹a Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²b Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China;³c Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Scandinavian Journal of Gastroenterology

关键词： Reactive hyperplasia;grade intraepithelial neoplasia;magnifying endoscopy;narrow-band imaging;diagnosis

摘要： Background and purpose Gastric reactive hyperplasia (RH) is a common benign lesion of the gastric mucosa that can be resolved by conservative treatme ...

作者： Yahui Zhang;Yi Lin;Guoqiang Li;Yuan Yuan;Xuejiao Wang;Na Li;Chuanhao Xiong;Yueying Yang;Yuhang Ma;Zhijian Zhang;Xiaoying Ding （¹Department of Endocrinology and Metabolism , Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China;²Shanghai Key Laboratory of Regulatory Biology , Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai , China;³Department of Neurology , Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai , China）

出处： Biology of Reproduction

摘要： Polycystic ovary syndrome (PCOS) is a complicated hormonal and metabolic disorder with hyperandrogenemia, insulin resistance and reproductive dysfunct ...

作者： 祝青青¹，靖大道²，刘嵬¹ （¹合肥京东方医院；²上海市第一人民医院）

出处： 中国新药与临床杂志

关键词： 卡瑞利珠单抗；程序性细胞死亡受体1；胃肠炎；药物不良反应

摘要： 免疫疗法作为肿瘤新兴治疗方法，主要利用人体免疫系统杀伤肿瘤细胞^'(1)'，免疫检查点抑制剂（immune checkpoint inhibitors， ICIs）是肿瘤免疫治疗的热点。卡瑞利珠单抗（camrelizumab ）是我国研发的程序性死亡受体1（programmed ...

作者： 牟东云^1,2，张艳金³，蒋立人¹，孙娟娟¹，曹毅⁴，高峰¹ （¹上海市第一人民医院病理中心；²贵州省遵义医药高等专科学校病理教研室；³贵州航天医院骨一科；⁴贵州省遵义医药高等专科学校卫管流行病与卫生统计学教研室）

出处： 重庆医学

摘要： 目的探讨磷酸化信号转导和转录活化因子3（p-STAT3）、程序性死亡分子1配体（PD-L1）在膀胱高级别浸润性尿路上皮癌组的表达及其临床意义。方法选取上海市第一人民医院病理中心2013年1月至2018年12月病理诊断的膀胱高级别浸润性尿路上皮癌患者74例，采用免疫组织化学法检测p-STAT3、PD- ...

作者： 张晓珍¹，刘鹏²，李斯雯²，李冰融²，蒋会茹²，张开勇²，耿子翔²，张必萌² （¹上海长海医院；²上海市第一人民医院）

出处： 实用中医内科杂志

关键词： 卵巢早衰；针药结合；针灸疗法；临床疗效

摘要： 目的：观察针药结合治疗卵巢早衰的临床疗效。方法：将63例卵巢早衰患者随机分为治疗组（32例）和对照组（31例），对照组采用单纯西药治疗，治疗组采用针灸结合西药治疗。治疗周期为6个月，观察两组患者临床疗效，检测对比分析血清促卵泡生成素（FSH）、雌二醇(E₂)、促黄体生成素（LH ...