作者： Hong Lang;Hang Zhang;Mengqing Ma;Xin Wan;Yuyang Chen;Qing Sun;Changchun Cao （Affiliations ¹ Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, 109 Longmian Road, Nanjing, Jiangsu 211166, China. ² Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Xinsongjiang Road, Shanghai 201620, China. ³ Department of Nephrology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu 210006, China. ⁴ Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, 109 Longmian Road, Nanjing, Jiangsu 211166, China. Electronic address: caochangchun@njmu.edu.cn.）

出处： Clinica chimica acta; international journal of clinical chemistry 0

关键词： Acute kidney injury;Cardiac surgery;Follistatin-like 1;Prediction;Protein array technology.

摘要： Background: Acute kidney injury (AKI) is a severe complication after cardiac surgery. The early prediction of AKI can facilitate timely intervention a ...

作者： Lulu Liu;Xin Guo;Yao Wang;Guo Li;Yanyan Yu;Yang Song;Chenhui Zeng;Zhilou Ding;Yuanjun Qiu;Feifei Yan;Yi-Xiang Zhang;Caiqi Zhao;Yan Zhang;Yali Dou;Peter Atadja;En Li;He Wang （Affiliations ¹ Novartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA 02139, USA; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China. ² Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China. ³ Institut Pasteur of Shanghai, 320 Yueyang Road, Shanghai 200031, China. ⁴ Department of Hematology, Shanghai General Hospital affiliated to Shanghai Jiao Tong University, No. 650 Songjiang Road, Shanghai 201620, China. ⁵ Department of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave., Los Angeles, CA 90007, USA. ⁶ Novartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA 02139, USA; Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai 201203, China. Electronic address: he.wang@novartis.com.）

出处： Biochimica et biophysica acta. Molecular basis of disease 0

关键词： MLL-rearranged leukemia;Myc targets;Ribosome genes;Wdr5.

摘要： WD repeat domain 5 (WDR5) is a prominent target for pharmacological inhibition in cancer through its scaffolding role with various oncogenic partners ...

作者： Xiao-Zhong Jing;Gai-Ying Li;Yu-Peng Wu;Xiang-Zhen Yuan;Xing-Guang Luo;Jia-Lin Chen;Reyisha Taximaimaiti;Xiao-Ping Wang;Jian-Qi Li （Affiliations ¹ Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: neurojxz@163.com. ² Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China. Electronic address: ligaiying@phy.ecnu.edu.cn. ³ Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China. Electronic address: 1531881866@qq.com. ⁴ Department of Neurology, Weifang People's Hospital, Weifang, Shandong, China. Electronic address: yuanxiangzhen@163.com. ⁵ Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. Electronic address: xingguang.luo@yale.edu. ⁶ Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China. Electronic address: johnnychen1900@outlook.com. ⁷ Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: rayisa1229@sina.com. ⁸ Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: x_p_wang@sjtu.edu.cn. ⁹ Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China. Electronic address: jqli@phy.ecnu.edu.cn.）

出处： Parkinsonism & related disorders 0

关键词： Deep gray matter nuclei;Free water imaging;Neurodegeneration;Wilson's disease.

摘要： Background: The bi-tensor free water imaging may provide more specific information in detecting microstructural brain tissue alterations than conventi ...

作者： Xiangui He;Padmaja Sankaridurg;Thomas Naduvilath;Jingjing Wang;Shuyu Xiong;Rebecca Weng;Linlin Du;Jun Chen;Haidong Zou;Xun Xu （Affiliations ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Center of Eye Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China. ³ National Clinical Research Center for Eye Diseases, Shanghai, China. ⁴ Brien Holden Vision Institute, Sydney, New South Wales, Australia p.sankaridurg@bhvi.org drxuxun@sjtu.edu.cn. ⁵ School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia. ⁶ Brien Holden Vision Institute, Sydney, New South Wales, Australia. ⁷ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Shanghai, China p.sankaridurg@bhvi.org drxuxun@sjtu.edu.cn.）

出处： The British journal of ophthalmology 0

关键词： diagnostic tests/investigation;embryology and development;epidemiology;optics and refraction;public health.

摘要： Purpose: To develop age-specific and gender-specific reference percentile charts for axial length (AL) and AL/corneal radius of curvature (AL/CR) and, ...

作者： Shengli Li;Li Yuan;Zhi-Yuan Xu;Jing-Li Xu;Gui-Ping Chen;Xiaoqing Guan;Guang-Zhao Pan;Can Hu;Jinyun Dong;Yi-An Du;Li-Tao Yang;Mao-Wei Ni;Rui-Bin Jiang;Xiu Zhu;Hang Lv;Han-Dong Xu;Sheng-Jie Zhang;Jiang-Jiang Qin;Xiang-Dong Cheng （Affiliations ¹ Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China. ² Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ³ Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China. ⁴ Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China. ⁵ First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China. ⁶ Department of Gastrointestinal Surgery, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China. ⁷ Biological Sample Bank, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China. ⁸ Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China. jqin@ucas.ac.cn. ⁹ Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China. jqin@ucas.ac.cn. ¹⁰ Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China. jqin@ucas.ac.cn. ¹¹ Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China. chengxd@zjcc.org.cn. ¹² Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China. chengxd@zjcc.org.cn. ¹³ Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China. chengxd@zjcc.org.cn.）

出处： Nature communications 0

摘要： The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and ...

作者： Jiling Feng;Zhichao Xi;Xue Jiang;Yang Li;Wan Najbah Nik Nabil;Mengfan Liu;Zejia Song;Xiaoqiong Chen;Hua Zhou;Qihan Dong;Hongxi Xu （Affiliations ¹ Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, 201203, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China; Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. Electronic address: fjlfreda@shutcm.edu.cn. ² School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China. Electronic address: xizhichao@shutcm.edu.cn. ³ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China. Electronic address: jiangxue96@shutcm.edu.cn. ⁴ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China. Electronic address: liyangsh1991@163.com. ⁵ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China; Pharmaceutical Services Program, Ministry of Health, Petaling Jaya, Selangor, 46200, Malaysia. Electronic address: najbah@yahoo.com. ⁶ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China. Electronic address: mengfanliu@shutcm.edu.cn. ⁷ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Faculty of Medicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland. ⁸ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China. Electronic address: Chenxiaoqiong92@163.com. ⁹ Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, 201203, China. Electronic address: zhouhua@shutcm.edu.cn. ¹⁰ Chinese Medicine Anti-Cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia. Electronic address: qihan.dong@sydney.edu.au. ¹¹ Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, 201203, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai, 201203, China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, No. 1200, Cailun Road, Shanghai, 201203, China. Electronic address: hxxu@shutcm.edu.cn.）

出处： Cancer letters 0

关键词： Akt;Induce autophagy;Prostate cancer;Quiescent cancer cells;SSA.

摘要： Quiescent cancer cells (QCCs), also known as dormant cancer cells, resist and survive chemo- and radiotherapy, resulting in treatment failure and late ...

作者： Hao Zhang;Jie-Mei Gu;Ai-Jun Chao;Qun Cheng;Dong-Hui Teng;Jin-Ming Yu;Bing-Wu Wang;Ya-Nan Huo;Li Mao;Qiu Zhang;Hong Yang;Shi-Gui Yan;Ke-Qin Zhang;Xue-Ling Zhao;Hua Lin;Yu Pei;Zhong Yuan;Ru-Chun Dai;Liang He;Li Chen;Yong-Feng Su;Zhong-Liang Deng;Li You;Bo Ban;Mei Zhu;You-Liang Cao;Yi-Kun Zhu;Zhi-Jun Li;Zhi Zhang;Cheng-Qing Yi;Yi-Bing Lu;Guang Wang;Cui-Cui Han;Zhen-Jiang Wang;Xian-Xing Li;Zhen-Lin Zhang （Affiliations ¹ Department of Osteoporosis and Bone Diseases, Shanghai Clinical Research Center of Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. ² Department of Osteo-Internal, Tianjin Hospital, Tianjin, 300211, China. ³ Department of Osteoporosis, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China. ⁴ Department of Orthopedics, Tianjin First Central Hospital, Tianjin, 300192, China. ⁵ Department of Endocrinology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530016, China. ⁶ Department of Spine Surgery, Weifang People's Hospital, Weifang, 261000, China. ⁷ Department of Endocrinology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, 330006, China. ⁸ Department of Endocrinology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, 223300, China. ⁹ Department of Endocrinology, The First Affillated Hospital of Anhui Medical University, Hefei, 230022, China. ¹⁰ Department of Endocrinology, Ruian People's Hospital, Wenzhou, 325200, China. ¹¹ Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. ¹² Department of Endocrinology, Tongji Hospital of Tongji University, Shanghai, 200065, China. ¹³ Department of Orthopedics, First Affillated Hospital of Kunming Medical University, Kunming, 650032, China. ¹⁴ Metabolic Bone Disease Prevention and Treatment Research Center, Nanjing Drum Tower Hospital, Nanjing, 210008, China. ¹⁵ Department of Endocrinology, Chinese PLA General Hospital, Beijing, 100853, China. ¹⁶ Department of Osteoporosis, Nanchang Hongdu Hospital of TCM, Nanchang, 330006, China. ¹⁷ Department of Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. ¹⁸ Department of Orthopedics, Beijing Jishuitan Hospital, Beijing, 100035, China. ¹⁹ Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, 250012, China. ²⁰ Department of Endocrinology, Inner Mongolia Baogang Hospital, Baotou, 014010, China. ²¹ Department of Spine Surgery, The second affiliated hospital of Chongqing medical university, Chongqing, 400010, China. ²² Department of Endocrinology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. ²³ Department of Endocrinology, Affiliated Hospital of Jining Medical University, Jining, 272007, China. ²⁴ Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin, 300052, China. ²⁵ Department of Orthopedics, The Third People's Hospital of Yunnan Province, Kunming, 650011, China. ²⁶ Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan, 030001, China. ²⁷ Department of Rheumatology and Immunology, The First Affillated Hospital of Bengbu Medical College, Bengbu, 233004, China. ²⁸ Department of Spine Surgery, Suining Central Hospital, Suining, 629000, China. ²⁹ Department of Orthopedics, Shanghai Pudong Hospital, Shanghai, 201399, China. ³⁰ Department of Endocrinology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China. ³¹ Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. ³² Department of Medical, Qilu Pharmaceutical Co., Ltd, Jinan, 250100, China. ³³ Department of Project, Qilu Pharmaceutical Co., Ltd, Jinan, 250100, China. ³⁴ Department of Statistical analysis, Qilu Pharmaceutical Co., Ltd, Jinan, 250100, China. ³⁵ Department of Osteoporosis and Bone Diseases, Shanghai Clinical Research Center of Bone Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China. zhangzl@sjtu.edu.cn.）

出处： Acta pharmacologica Sinica 0

关键词： Chinese women;adverse events;bone mineral density;bone turnover markers;denosumab biosimilar;postmenopausal osteoporosis.

摘要： The current study evaluated the efficacy and safety of a denosumab biosimilar, QL1206 (60 mg), compared to placebo in postmenopausal Chinese women wit ...

作者： 周吉银¹，盛艾娟²，刘强³，蒋辉⁴，王美霞⁵，白桦⁶，江一峰⁷，徐蕾⁸，刘丹¹，熊宁宁⁹ （¹陆军军医大学第二附属医院国家药物临床试验机构；²首都医科大学附属北京佑安医院伦理办公室；³世界中医药学会联合会评价中心；⁴福建医科大学附属漳州市医院科教科；⁵北京积水潭医院国家药物临床试验机构办公室；⁶中国医学科学院北京协和医院科研处；⁷上海交通大学附属第一人民医院伦理办公室；⁸大连医科大学附属第一医院伦理办公室；⁹江苏省中医院伦理委员会）

出处： 中国医学伦理学

关键词： 涉及人的生命科学和医学研究；伦理审查；委托；指引

摘要： 《涉及人的生物医学研究伦理审查办法》（2016年）第七条规定，未设立伦理委员会的医疗卫生机构，不得开展涉及人的生物医学研究。2022年3月中共中央办公厅和国务院办公厅《关于加强科技伦理治理的意见》明确，不具备设立科技伦理（审查）委员会条件的单位，应委托其他单位科技伦理（审查）委员会开展审查。《涉及人 ...

作者： Tang L.;Luo D.;Qiu Q.;Xu G.-T.;Zhang J. （¹Department of Ophthalmology of Tongji Hospital and Laboratory of Clinical and Visual Sciences of Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China;²Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University, Shanghai, China;³National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China;⁴Department of Ophthalmology, Shigatse People’s Hospital, Xizang, China）

出处： Ophthalmic Research

关键词： Diabetic macular edema;Hyperreflective foci;External limiting membrane;Ellipsoid zone;Optical coherence tomography angiography

摘要： Introduction: Objectives of the study were to describe the hyperreflective foci (HRF) on optical coherence tomography angiography in diabetic macular ...

作者： Jialing Zhang;Li Cao;Wenji Wang;Yu Huo;Yuanzheng Zheng;Fang Wu;Yonghao Gui （¹Institute of Pediatrics, Children’s Hospital of Fudan University, Shanghai, China NHC Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China;²Ultrasound Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China;³NHC Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Cardiovascular Center, Children’s Hospital of Fudan University, Shanghai, China;⁴Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Journal of Developmental Origins of Health and Disease

关键词： Oxidative stress;prenatal overnutrition;antioxidants;ventricular remodeling;cardiac dysfunction

摘要： Maternal overnutrition-induced fetal programming predisposes offspring to cardiovascular health issues throughout life. Understanding how these advers ...