作者： 曹军生¹，彭珊¹，车辙¹，成青鉴¹，孟庆友² （¹河西学院附属张掖人民医院血管外科；²上海交通大学附属第一人民医院(上海市第一人民医院)血管外科）

出处： 中国普外基础与临床杂志

关键词： 主动脉弓动脉瘤；夹层；开窗；腔内治疗

摘要： 1病例资料1.1一般资料患者男性,41岁,以“胸背部撕裂样疼痛2 h”为主诉于2020年1月19日收住河西学院附属张掖人民医院血管外科。患者既往有高血压病史多年且未正规服药及监测血压,血压最高达210/150 mmHg（1 mmHg=0.133 kPa）。无糖尿病、冠心病等其他病史。入院时患者血压为 ...

作者： Lin Chen^{1 na1};Ling Pan^{1 na1};Yuexi Zeng¹;Xiaonan Zhu¹ & …Li You ¹ （¹Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China）

出处： Cell and Tissue Research

关键词： Sarcopenia;CPNE1;Endoplasmic reticulum stress;PERK;eIF2α

摘要： Sarcopenia is characterized by a progressive reduction in muscle mass or muscle physiological function associated with aging, but the relevant molecul ...

作者： 史咏鑫，贲素琴，肖辉 （上海交通大学附属第一人民医院）

出处： 中国肿瘤

关键词： 肥大细胞；肿瘤；肿瘤微环境；脱颗粒

摘要： 肥大细胞（MC）是炎症和过敏反应中的重要效应细胞，通过脱颗粒释放介质参与免疫调节。近年来研究发现MC所释放的可溶性介质在肿瘤微环境中介导肿瘤组织血管生成、基质分解和免疫调控，进而发挥着促进或抑制肿瘤发展的双重作用。以MC为靶点的治疗手段也取得了一定的进展。全文回顾MC颗粒释放的机制及其在肿瘤微环境中 ...

作者： 刘倩倩，姚升宇，陈旭明，侯灵通，胡喆恺 （上海市第一人民医院）

出处： 中国辐射卫生

关键词： 4D；CT；CT模拟定位；图像重建；呼吸运动

摘要： 目的 比较2种呼吸信号采集方式对运动靶区勾画的影响。方法 正方体模体（内含球体）置于运动平台上，设置运动周期、频率和方向，模拟呼吸运动。分别利用RPM法和GE法进行呼吸信号采集，在最大密度投影（MIP）序列进行靶区勾画。比较正方体和球体不同呼吸信号采集方式下各自重建体积与理论运动体积差异。结果 同一 ...

作者： 王敏¹，张威浩²，刘俊¹，杨烨³，师晓琴⁴ （¹上海市第一人民医院普外科；²上海和睦家医院外科；³上海市第一人民医院妇产科；⁴上海市第一人民医院病理科）

出处： 肿瘤

关键词： 甲状腺乳头状癌；细针吸取细胞学检查；BRAF；V600E；甲状腺外侵犯

摘要： 目的：探讨术前细针吸取细胞学检查（ne-needle aspiration cytology,FNAC）联合BRAFV600E突变检测对于甲状腺乳头状癌（papillary thyroid carcinoma,PTC）病理结局的预测价值。方法 ：选择术前在超声引导下进行FNAC和BRAF V600E ...

作者： 沈婷^1,2，李群^2,3，钟力炜^1,2，王慧新^1,2，钟臻^1,2，顾捷飞^1,2 （¹上海市中医医院医务处；²市级医院病种质量与安全研究中心；³上海市第一人民医院医务处）

出处： 华西医学

关键词： 疫情防控管理；日间手术管理；国家推荐目录

摘要： 目的 探讨上海特色日间手术目录，为进一步推进日间手术的发展、聚焦适宜病种提供政策支撑。方法 收集2021年1月1日—9月30日和2022年1月1日—9月30日上海市级医院收治的24 h内出院的日间手术患者数据。比较2021年和2022年的日间手术病例数、均次费用以及手术病种趋势变化，归类总结适合常态 ...

作者： 成月佳^1,2，沈兵²，李群³，陈敏⁴，郑悦¹，余松轩²，侯冷晨² （¹上海市胸科医院.上海交通大学医学院附属胸科医院医务部；²上海申康医院发展中心医疗事业部；³上海市第一人民医院医务部；⁴上海市儿童医院.上海交通大学附属儿童医院信息部）

出处： 华西医学

关键词： 日间手术；加速康复外科；结构-过程-结果评价指标

摘要： 目的 依据上海市级医院开展日间手术现况，建立基于加速康复外科（enhanced recovery after surgery, ERAS）的日间手术“结构-过程-结果”评价指标体系。方法 选择2019年—2021年上海36家市级医院开展的短病程手术患者的病案首页数据。分析日间手术开展情况，确定日间手 ...

作者： Zhixuan Chen;Jieqiong Chen;Min Gao;Yang Liu;Yidong Wu;Yafang Wang;Yuanyuan Gong;Suqin Yu;Wenjia Liu;Xiaoling Wan;Xiaodong Sun （Affiliations ¹ Department of Ophthalmology, School of Medicine, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, China. ² Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Department of Ophthalmology, Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. ⁴ Department of Ophthalmology, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.）

出处： Human mutation 0

关键词： Alu-Alu mediated rearrangement;PRPF31;copy number variation;retinitis pigmentosa.

摘要： Retinitis pigmentosa (RP) is a monogenic disease characterized by irreversible degeneration of the retina. PRPF31, the second most common causative ge ...

作者： Yifan Hu;Jieqiong Chen;Yuwei Wang;Junran Sun;Peirong Huang;Jingyang Feng;Te Liu;Xiaodong Sun （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), National Clinical Research Center for Ophthalmic Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. ² Department of Ophthalmology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, and Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China. ⁴ Central Laboratory, Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.）

出处： Cell biology international 0

关键词： N6-methyladenosine;age-related macular degeneration;amyloid-β;fat mass and obesity-associated protein;m6A-mRNA epi-transcriptomic microarray;retinal pigment epithelium.

摘要： Amyloid-β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age-related macular degeneration (AMD ...

作者： Chaoyang Zhang;Dawei Luo;Hai Xie;Qian Yang;Dandan Liu;Lei Tang;Jingting Zhang;Weiye Li;Haibin Tian;Lixia Lu;Xiaodong Sun;Guo-Tong Xu;Jingfa Zhang （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China; Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ³ Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. ⁴ Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China; Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, United States. ⁵ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: xdsun@sjtu.edu.cn. ⁶ Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. Electronic address: gtxu@tongji.edu.cn. ⁷ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China; Department of Regenerative Medicine, and Department of Pharmacology, Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. Electronic address: 13917311571@139.com.）

出处： Pharmacological research 0

关键词： Aquaporin 11;Diabetic macular edema;Diabetic retinopathy;MicroRNAs;Müller intracellular edema;Na(+)-K(+)-ATPase.

摘要： Retinal Müller glial dysfunction and intracellular edema are important mechanisms leading to diabetic macular edema (DME). Aquaporin 11 (AQP11) is pri ...