作者： Li, Qin;Xu, Yuan;Li, Xiaoyu;Guo, Yankun;Liu, Gaolin （1 Department of Pharmacology, Shanghai First People\'s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China）

出处： Toxicology Letters 2012 Vol.211 No.2 P91-97

关键词： MI;Myocardial fibrosis;Rho-kinase;TAC;TGF-β1–TAK1

摘要： Inhibition of Rho-kinase displays vasodilation property although its effect on cardiac remodeling in heart against pressure overload and ischemia has ...

作者： Wang, Q.;Wen, Y.-G.;Li, D.-P.;Xia, J.;Zhou, C.-Z.;Yan, D.-W.;Tang, H.-M.;Peng, Z.-H. （a Department of General Surgery, Shanghai First People\'s Hospital, Shanghai Jiao Tong University, 85 Wujin Road, 200080 Shanghai, China; b Department of Pathology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University, 85 Wujin Road, 200080 Shanghai, China）

出处： Medical Oncology 2012 Vol.29 No.1 P77-83

关键词： Enrichment;Gastric cancer;Marker;Microarray;Prognosis

摘要： Expression microarrays are widely used for investigating the candidate molecular targets in human cancer. While genome-wide expression signatures scre ...

作者： Yan, J.-E.;Yuan, W.;Lou, X.;Zhu, T. （a Department of Anesthesia, Guiyang Medical College, Guiyang, China; b Department of gynecology and obstetrics, Songjiang Branch, Shanghai First People\'s Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China; c Central Laboratory, Songjiang Branch, Shanghai First People\'s Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China; d Department of Anesthesia, Songjiang Branch, Shanghai First People\'s Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China）

出处： Neuroscience Letters 2012 Vol.526 No.1 P54-58

关键词： Diabetes;Interleukin-1 beta;Neuropathic pain;Toll-like receptor;Tumor necrosis factor-alpha

摘要： Neuropathic pain is one of the common complications of diabetes mellitus, and current treatments often do not meet medical needs. Toll-like receptor 4 ...

作者： Li, H.;Xu, H.;Sun, B. （Department of Cardiology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai 200080, China）

出处： Molecular Medicine Reports 2012 Vol.6 No.4 P774-778

关键词： Lipopolysaccharide;Matrix metalloproteinases;Nuclear factor-κB;Toll-like receptor 4

摘要： Matrix metalloproteinases (MMPs) are critical to vascular smooth muscle cell migration in vivo. The dysregulation of MMPs is involved in the pathogene ...

作者： Chen, H.-Y.;Han, Z.-B.;Fan, J.-W.;Xia, J.;Wu, J.-Y.;Qiu, G.-Q.;Tang, H.-M.;Peng, Z.-H. （a Department of General Surgery, Shanghai Jiao Tong University, Shanghai First People\'s Hospital, 85 Wujin Road, Shanghai 200080, China; b Department of Pathology, Shanghai Jiao Tong University, Shanghai First People\'s Hospital, Shanghai 200080, China）

出处： Medical Oncology 2012 Vol.29 No.3 P1859-1865

关键词： Hepatocellular carcinoma;Liver transplantation;MiR-203;Prognosis

摘要： Many recent studies have shown the utility of microRNAs (miRs) as cancer-related biomarkers. The aim of the present study was to evaluate the correlat ...

作者： Yang Lili;Wei Yi;Yang Ji;Sun Yue;Shi Weimin;Li Ming （1 Departments of dermatology, Zhongshan Hospital, Fudan University, Shanghai, China 2 Departments of dermatology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, China）

出处： PLoS ONE 2012 Vol.7 No.5 P1-10

关键词： SYSTEMIC-LUPUS-ERYTHEMATOSUS;AUTOIMMUNE VITILIGO;DISEASE-ACTIVITY;IFN-GAMMA;FOXP3;CD4(+);RESPONSES;EFFECTOR;SUBSETS

摘要： Melanocyte-specific CD8+ cytotoxic T lymphocytes (CTLs) play a pivotal role in vitiligo-induced depigmentation. Yet, the mechanisms underlying the hig ...

作者： Gao, K.;Gao, W.;Huang, J.;Wu, X.;Wang, C.S.;Wang, Q. （Department of Orthopedics, Shanghai First People\'s Hospital, Shanghai Jiaotong University, 100 Haining Road, Hongkou District Shanghai 200080, China）

出处： Medical Principles and Practice 2012 Vol.21 No.5 P483-487

关键词： Bone graft;Locked plate;Proximal humeral nonunion

摘要： Objectives: To determine whether using a fixed-angle locked plate plus a fibular strut autograft to treat humeral surgical neck nonunions can result i ...

作者： Liu, Qiang ;Yao, Jun-yan ;Qian, Cheng ;Chen, Rong ;Li, Xiao-yu ;Liu, Shao-wen ;Sun, Bao-gui ;Song, Long-sheng ;Hong, Jiang （1 Department of Cardiology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China 2 Department of Anesthesiology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China 3 Department of Clinical Pharmacology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China 4 Division of Cardiology, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA, USA）

出处： Acta Pharmacologica Sinica 2012 Vol.33 No.12 P1495-1501

关键词： propofol;cardiac ischemia;ventricular arrhythmias;ventricular fibrillation;mitochondrial KATP channels;5-hydroxydecanoate;diazoxide;cardiomyocytes

摘要： Aim:To investigate the potential of propofol in suppressing ventricular arrhythmias and to examine whether mitochondrial ATP-sensitive potassium chann ...

作者： Shen, J.;Wan, R.;Hua, G.;Yang, L.;Xiong, J.;Wang, F.;Shen, J.;He, S.;Guo, X.;Ni, J.;Guo, C.;Wang, X. （a Department of Gastroenterology, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China; b Department of Gastroenterology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Pancreatology 2012 Vol.12 No.2 P91-99

关键词： Apoptosis;Bcl-2;miR-15b;miR-16;Pancreatic stellate cells

摘要： Objectives: Activated pancreatic stellate cells (PSCs) play a pivotal role in the development of pancreatic diseases, especially chronic pancreatitis ...

作者： Guo Y;Fan Y;Qiu J;Liu Y;Gao J;Guo F （Organ Transplantation Center, Shanghai First People\'s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. gyfslm@gmail.com;）

出处： PLoS One 2012 Vol.7 No.12

摘要： Genetic polymorphisms in cytotoxic T lymphocyte-associated antigen 4 (CTLA4) play an influential role in graft rejection and the long-term clinical ou ...