作者： Ning R;Chen G;Fang R;Zhang Y;Zhao W;Qian F （Department of Orthopaedics, The Third Affiliated Hospital of Anhui Medical University, 390 Huaihe Road, Hefei, 230031, China. nrd192@qq.com. ; Department of Orthopaedics, The Third Affiliated Hospital of Anhui Medical University, 390 Huaihe Road, Hefei, 230031, China. ; Department of Orthopaedics, The Third Affiliated Hospital of Anhui Medical University, 390 Huaihe Road, Hefei, 230031, China. ; Department of Otolaryngology Head and Neck Surgery, Shanghai General Hospital, 85 Wu Jin Road, Shanghai, 200080, China. ; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China. zhaowj@sjtu.edu.cn. ; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.;）

出处： Biological research 2021

关键词： Apoptosis;Cell proliferation;Diosmetin;Osteosarcoma;Signal transducer and activator of transcription 3 (STAT3)

摘要： Background: Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitu ...

作者： Chen Liu  ¹, Yuhan Huang  ², Tianyu Qin  ¹, Lixin You  ¹, Funian Lu  ¹, Dianxing Hu  ¹, Rourou Xiao  ¹, Xu Qin  ¹, Ensong Guo  ¹, Bin Yang  ¹, Xi Li  ¹, Junpeng Fan  ¹, Xiong Li  ¹, Yu Fu  ¹, Si Liu  ¹, Zhuozi Wang  ¹, Yingyu Dou  ¹, Wei Wang  ¹, Wenting Li  ¹, Xiaohang Yang  ¹, Jingbo Liu  ¹, Wenju Peng  ¹, Li Zhang  ¹, Yaoyuan Cui  ¹, Chaoyang Sun  ³, Gang Chen  ⁴ （Affiliations 1 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. 2 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: suncydoctor@gmail.com. 4 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: gumpc@126.com.）

出处： Cancer letters 2021

关键词： AZD5153;Ovarian cancer;PDO;PDX;Palbociclib.

摘要： The CDK4/6 inhibitor, palbociclib has recently entered clinic-trial stage for breast cancer treatment. However, translating its efficacy to other soli ...

作者： Yongang Li  ¹, Zongshan Li  ², Jiachen Gu  ³, Xiaomin Xu  ⁴, Huimin Chen  ⁴, Yaxing Gui  ⁵ （Affiliations 1 Department of Neurology, The First People\' Hospital of Wenling, Wenling, China. 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 3 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 4 Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 5 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. Electronic address: YaxingGui@shsmu.edu.cn.）

出处： Neuroscience letters 2021 P136414

关键词： Exosome;Parkinson’s disease;Wnt5a;neuronal inflammation.

摘要： Our previous investigation shown Wnt signal pathway was significantly activated during DA neuron differentiation of epiblast-derived stem cells. In th ...

作者： Yulan Liu^1,2; Shanshan Deng¹; Zhibing Song³; Qian Zhang³; Yuchen Guo³; Yongsheng Yu¹; Yuliang Wang⁴; Tiejun Li¹; Fayed A K Megahed⁵; Tamer A Addissouky⁶; Junqin Mao⁷; Yuefan Zhang¹ （1 School of Medicine, Shanghai University, Shanghai, China. 2 Department of Pharmacy, The Air Force Hospital From Eastern Theater of PLA, Nanjing, China. 3 College of Pharmacology, Anhui University of Chinese Medicine, Hefei, China. 4 Joint International Research Laboratory of Metabolic and Developmental Sciences, Key Laboratory of Urban Agriculture (South) Ministry of Agriculture, Plant Biotechnology Research Center, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. 5 Nucliec Acid Research Departement, Genetic Engineering and Biotechnological Research Institute, City of Scientific Research and Technological Applications, Alexandria, Egypt. 6 MLS Ministry of Health, Alexandria, Egypt. 7 Department of Clinical Pharmacy, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Frontiers in pharmacology 2021 Vol.12 P725268

关键词： brain ischemia;eukaryotic translation elongation factor 1A1 (eEF1A1);inflammation;microglia polarization;monocyte locomotion inhibitory factor (MLIF).

摘要： Monocyte locomotion inhibitory factor (MLIF) is a heat-stable pentapeptide from Entamoeba histolytica. Our previous study found that MLIF protects aga ...

作者： Haochen Guan¹; Zhi Geng²; Weijie Yuan¹; Bowen Chang³ （1 Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Neurology, Second People\'s Hospital of Hefei City, The Hefei Affiliated Hospital of Anhui Medical University, Hefei, China. 3 Division of Life Sciences and Medicine, Department of Neurosurgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.）

出处： Frontiers in neuroscience 2021 Vol.15 P755056

关键词： Burke-Fahn-Marsden dystonia rating scale score;Meige’s syndrome;antioxidants;movement disorders;uric acid.

摘要： Uric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson\'s di ...

作者： Nan Zhu¹; Ling Wang¹; Huimin Guo²; Jieshuang Jia¹; Lijie Gu¹; Xuan Wang¹; Man Yang¹; Haochen Guan¹; Weijie Yuan¹ （1 Department of Nephrology, Shanghai General Hospital, Shanghai, China. 2 Department of Nuclear Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, China.）

出处： Frontiers in physiology 2021 Vol.12 P712147

关键词： SP4;STAT3;angiogenesis;peritoneal dialysis;thalidomide.

摘要： Peritoneal angiogenesis is the key pathophysiological factor that limits peritoneal ultrafiltration during peritoneal dialysis (PD) in uremic patients ...

作者： Siwei Ye¹; Ming Yang¹; Yuanfei Zhu¹; Xiaochen Gao¹; Fan Meng¹; Ruiliang Wu²; Bo Yu² （1 Department of Instrument Science and Engineering, Shanghai Jiao Tong University, Shanghai, China. 2 Department of Rehabilitation, Shanghai General Hospital, Shanghai, China.）

出处： Computer methods in biomechanics and biomedical engineering 2021 P1-11

关键词： Enhanced external counterpulsation;cerebral blood flow;hemodynamic simulation;ischemic stroke;numerical modeling.

摘要： Based on the changes in phase characteristics of blood flow and pressure, enhanced external counterpulsation (EECP) reduces cardiac load and improves ...

作者： Gang Tang¹; Yi Du¹; Haochen Guan¹; Jieshuang Jia¹; Nan Zhu¹; Yuping Shi¹; Shu Rong¹; Weijie Yuan¹ （1 Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.）

出处： British journal of pharmacology 2021

关键词： FFA2;butyrate;db/db mice;diabetic nephropathy;muscle atrophy.

摘要： Background and purpose: Muscle protein catabolism in patients with diabetic nephropathy (DN) results in striking losses of muscle proteins, which incr ...

作者： Xiao-Jun Wang  ^{1   2} , Yi-Ding Qi  ³ , Hao-Chen Guan  ⁴ , Hua-Gang Lin  ⁵ , Pei-Qing He  ¹ , Kang-Wei Guan  ¹ , Lei Fu  ² , Mao-Qing Ye  ^{2   3} , Jing Xiao  ^{2   5} , Tao Wu  ^{1   2} （Affiliations 1 Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China. 2 Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China. 3 Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China. 4 Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, China.）

出处： Frontiers in pharmacology 2021

关键词： Gegen Qinlian decoction;NLRP3;apoptosis;hyperuricemia;pharmacological network analysis.

摘要： Background: Gegen Qinlian decoction (GGQLD) is a typical traditional Chinese medicine (TCM) prescription documented in Shang Han Lun. Clinically, GGQL ...

作者： Bowen Chang  ¹ , Haochen Guan  ² , Xueyi Wang  ¹ , Zheng Chen  ¹ , Wanchun Zhu  ¹ , Xiangyu Wei  ¹ , Shiting Li  ¹ （Affiliations 1 Department of Neurosurgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China. 2 Department of Nephrology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Frontiers in molecular biosciences 2021

关键词： COX4I2;HHV7;Schwann cells;apoptosis;ferroptosis.

摘要： Emerging evidence suggests that reactive oxygen species (ROS) play a significant role in the pathogenesis of peripheral nerve damage. Our previous stu ...