作者： Xiao-Jun Wang;Xiao-Jun Wang;Yi-Ding Qi;Hao-Chen Guan;Hua-Gang Lin;Pei-Qing He;Kang-Wei Guan;Lei Fu;Mao-Qing Ye;Mao-Qing Ye;Jing Xiao;Jing Xiao;Tao Wu;Tao Wu （Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China）

出处： Frontiers in Pharmacology 2021

关键词： Gegen Qinlian decoction;hyperuricemia;NLRP3;apoptosis;pharmacological network analysis

摘要： Background: Gegen Qinlian decoction (GGQLD) is a typical traditional Chinese medicine (TCM) prescription documented in Shang Han Lun. Clinically, GGQL ...

作者： Bowen Chang;Haochen Guan;Xueyi Wang;Zheng Chen;Wanchun Zhu;Xiangyu Wei;Shiting Li （Department of Neurosurgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Nephrology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Neurosurgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Neurosurgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Neurosurgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Neurosurgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Neurosurgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China）

出处： Frontiers in Molecular Biosciences 2021

关键词： COX4I2;HHV7;Schwann cells;ferroptosis;apoptosis

摘要： Emerging evidence suggests that reactive oxygen species (ROS) play a significant role in the pathogenesis of peripheral nerve damage. Our previous stu ...

作者： Fusheng Ke  ¹ , Yinhui Huang  ² , Zhexiu Jin  ¹ , Lei Huang  ¹ , Qiang Xiong  ³ , Fang Jia  ¹ , Yu Chen  ⁴ , Gang Chen  ⁵ （Affiliations 1 Department of Cardiology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China. 2 Department of Neurology, Jinjiang Municipal Hospital, Jinjiang, China. 3 Department of Emergency, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China. 4 Department of Pediatrics, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, China. 5 Department of Cardiology, Shanghai General Hospital, Shanghai, China.）

出处： The Journal of international medical research 2021

关键词： Atrial fibrillation;Doppler echocardiography;catheter ablation;left atrium;mitral regurgitation;pulmonary vein.

摘要： Objective: The present study aimed to investigate the effect of functional mitral regurgitation (FMR) on recurrence of paroxysmal atrial fibrillation ...

作者： Jiyuan Hui  ¹ , Junfeng Feng  ¹ , Yue Tu  ² , Weituo Zhang  ³ , Chunlong Zhong  ⁴ , Min Liu  ⁴ , Yuhai Wang  ⁵ , Liansheng Long  ⁶ , Ligang Chen  ⁷ , Jinfang Liu  ⁸ , Chaohui Mou  ⁹ , Binghui Qiu  ¹⁰ , Xianjian Huang  ¹¹ , Qibing Huang  ¹² , Nu Zhang  ¹³ , Xiaofeng Yang  ¹⁴ , Chaohua Yang  ¹⁵ , Lihong Li  ¹⁶ , Rong Ma  ¹ , Xiang Wu  ¹ , Jin Lei  ¹ , Yong Jiang  ⁷ , Liang Liu  ⁷ , Guoyi Gao  ¹⁷ , Jiyao Jiang  ^{1   11   14} , LTH-1 Trial collaborators （Affiliations 1 Head Trauma Center, Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University/School of Medicine, Shanghai Institute of Head Trauma, Shanghai, China. 2 Neurological Intensive Care Unit, Beijing Chaoyang Integrative Medicine Emergency Medical Center, Beijing, China. 3 Clinical Research Institute, Shanghai Jiao Tong University/School of Medicine, Shanghai, China. 4 Department of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. 5 Department of Neurosurgery, Taihu Hospital, Wuxi, China. 6 Department of Neurosurgery, South Taihu Hospital, Huzhou, China. 7 Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China. 8 Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China. 9 Department of Neurosurgery, Taizhou First People\'s Hospital, Zhejiang, China. 10 Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. 11 Department of Neurosurgery, Shenzhen Second People\'s Hospital, Shenzhen, China. 12 Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, China. 13 Department of Neurosurgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 14 Emergency and Trauma Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. 15 Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China. 16 Department of Neurosurgery, Tangdu Hospital, Xi\'an, China. 17 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： EClinicalMedicine 2021 Vol.32 P100732

关键词： Efficacy;Prolonged hypothermia;Randomized controlled trial;Safety;Traumatic brain injury.

摘要： Background: Therapeutic hypothermia may need prolonged duration for the patients with severe traumatic brain injury (sTBI). Methods: The Long-Term Hyp ...

作者： Nuo Yu^1,2;Wenzhi Tu^3,2;Pu Qiu¹;Qian Ren¹;Xuming Chen³;Meifang Zhu¹;Yong Liu³CA1;Zhigang Chen¹CA2 （1 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China; 2 These authors contributed equally to this work.; 3 Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China）

出处： Nano Today 2022 Vol.43 P101427

关键词： Ultrasmall in nano;Cell membrane;Biodegradable;Phototherapy;X-ray therapy

摘要： The overall therapeutic output is significantly affected by the route of nanomedicines in vivo, including the successive steps of delivery, exogenous ...

作者： Haochen Guan¹;Nan Zhu¹;Gang Tang¹;Yi Du¹;Ling Wang¹;Weijie Yuan¹ （¹Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine）

出处： Cell & Bioscience 2022

关键词： Hepatitis B virus-associated glomerulonephritis;Hepatitis B virus X protein;DNA methylation;Phosphatase and tensin homolog;Vitamin D receptor

摘要： Background Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in h ...

作者： Jinxi Li^1,2,3;James D. Glover^4,3;Haiguo Zhang^5,3;Meifang Peng^2,5,3,6;Jingze Tan⁵;Chandana Basu Mallick^4,7;Dan Hou⁸;Yajun Yang⁵;Sijie Wu^1,2;Yu Liu²;Qianqian Peng²;Shijie C. Zheng²;Edie I. Crosse⁹;Alexander Medvinsky⁹;Richard A. Anderson¹⁰;Helen Brown⁴;Ziyu Yuan¹¹;Shen Zhou¹²;Yanqing Xu¹³;John P. Kemp¹⁴;Yvonne Y.W. Ho¹⁵;Danuta Z. Loesch¹⁶;Lizhong Wang¹⁷;Yingxiang Li¹⁷;Senwei Tang¹⁷;Xiaoli Wu¹⁷;Robin G. Walters^18,19;Kuang Lin¹⁸;Ruogu Meng²⁰;Jun Lv²¹;Jonathan M. Chernus²²;Katherine Neiswanger²³;Eleanor Feingold²²;David M. Evans^14,24,25;Sarah E. Medland¹⁵;Nicholas G. Martin¹⁵;Seth M. Weinberg^22,23,26;Mary L. Marazita^22,23,27,28;Gang Chen¹⁷;Zhengming Chen^18,19;Yong Zhou²⁹;Michael Cheeseman⁴;Lan Wang⁸;Li Jin^1,2,30,31CA1;Denis J. Headon^4,31CA2;Sijia Wang^2,32,31,33CA3 （1 State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200438, PRC; 2 CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC; 3 These authors contributed equally; 4 The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK; 5 Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PRC; 6 Present address: The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics and Endocrinology, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PRC; 7 Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 8 Chinese Academy of Sciences Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC; 9 Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK; 10 MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK; 11 Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu 225326, PRC; 12 Shanghai Foreign Language School, Shanghai 200083, PRC; 13 Forest Ridge School of the Sacred Heart, Bellevue, WA 98006, USA; 14 University of Queensland Diamantina Institute, University of Queensland, Brisbane, QLD, Australia; 15 QIMR Berghofer Medical Rese Institute, Brisbane, QLD, Australia; 16 Psychology Department, La Trobe University, Melbourne, VIC, Australia; 17 WeGene, Shenzhen, Guangdong 518040, PRC; 18 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; 19 Medical Research Council Population Health Research Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; 20 Center for Data Science in Health and Medicine, Peking University, Beijing 100191, PRC; 21 Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, PRC; 22 Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA; 23 Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA; 24 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; 25 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; 26 Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA; 27 Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA 15261, USA; 28 Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA; 29 Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PRC; 30 Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058), Chinese Academy of Medical Sciences, Shanghai 200438, PRC; 31 Senior author; 32 Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, PRC; 33 Lead contact）

出处： Cell 2022 Vol.185 No.1 P95-112(e18)

关键词： fingerprint pattern;genetics;genome-wide association study;trans-ethnic meta-analysis;limb development;EVI1

摘要： Fingerprints are of long-standing practical and cultural interest, but little is known about the mechanisms that underlie their variation. Using genom ...

作者： Tao Wang ^{#  1   2   3}, Jiaxiang Bai ^{#  4}, Min Lu  ¹, Chenglong Huang  ³, Dechun Geng  ⁴, Gang Chen  ³, Lei Wang  ¹, Jin Qi  ⁵, Wenguo Cui  ⁶, Lianfu Deng  ⁷ （Affiliations 1 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. 2 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, P. R. China. 3 Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of Orthopaedics, The second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, 314000, Jiaxing, P. R. China. 4 Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, P. R. China. 5 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. jinjin838@hotmail.com. 6 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. wgcui80@hotmail.com. 7 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. lf_deng@126.com.）

出处： Nature communications 2022 Vol.13 No.1 P160

摘要： Immune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous bio ...

作者： Yongang Li  ¹, Jiachen Gu  ², Youbing Mao  ³, Xijia Wang  ¹, Zongshan Li  ⁴, Xiaomin Xu  ⁴, Huimin Chen  ⁴, Yaxing Gui  ⁵ （Affiliations 1 Department of Neurology, The First People\'s Hospital of Wenling, Wenling, China. 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. 3 Department of Neuroelectrophysiology, The First People\'s Hospital of Wenling, Wenling, China. 4 Department of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. 5 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. YaxingGui@shsmu.edu.cn.）

出处： Molecular neurobiology 2022

关键词： Autoimmune encephalitis (AE);Exosomes;Herpes simplex encephalitis (HSE);microRNAs.

摘要： Encephalitis mediated by autoantibodies against neuronal antigens and herpes simplex encephalitis (HSE) are seemingly separate causes of encephalopath ...

作者： Shujie Wang  ^{1   2}, Huahui Ren  ^{3   4}, Huanzi Zhong  ³, Xinjie Zhao  ⁵, Changkun Li  ^{1   2   6}, Jing Ma  ⁶, Xuejiang Gu  ⁷, Yaoming Xue  ⁸, Shan Huang  ⁹, Jialin Yang  ¹⁰, Li Chen  ¹¹, Gang Chen  ¹², Shen Qu  ¹³, Jun Liang  ¹⁴, Li Qin  ¹⁵, Qin Huang  ¹⁶, Yongde Peng  ¹⁷, Qi Li  ⁵, Xiaolin Wang  ⁵, Yuanqiang Zou  ³, Zhun Shi  ³, Xuelin Li  ^{1   2}, Tingting Li  ^{1   2}, Huanming Yang  ^{3   18}, Shenghan Lai  ¹⁹, Guowang Xu  ⁵, Junhua Li  ³, Yifei Zhang  ^{1   2}, Yanyun Gu  ^{1   2}, Weiqing Wang  ^{1   2} （Affiliations 1 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the Pr China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 BGI-Shenzhen, Shenzhen, China. 4 Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark. 5 Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian, China. 6 Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, China. 8 Nanfang Hospital, Southern Medical University, Guangdong Province, China. 9 Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 10 Department of Endocrinology, Central Hospital of Minhang District, Shanghai, China. 11 Department of Endocrinology, Qilu Hospital of Shandong University, Shandong Province, China. 12 Department of Endocrinology, Fujian Provincial Hospital, Fujian Province, China. 13 Department of Endocrinology, Shanghai Tenth People\'s Hospital of Tong Ji University, Shanghai, China. 14 Department of Endocrinology, Xuzhou Central Hospital, Jiangsu Province, China. 15 Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 16 Chang Hai Hospital, Second Military Medical University, Shanghai, China. 17 Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 18 James D. Watson Institute of Genome Sciences, Hangzhou, China. 19 Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.）

出处： Gut microbes 2022 Vol.14 No.1 P2003176

关键词： Type 2 diabetes;berberine;dyslipidemia;gut microbiome;postprandial lipidemia;probiotics.

摘要： Non-fasting lipidemia (nFL), mainly contributed by postprandial lipidemia (PL), has recently been recognized as an important cardiovascular disease (C ...