作者： 宋伟华，谢欣辛，魏强华 （上海交通大学附属上海市第一人民医院临床药学科；上海交通大学附属上海市第一人民医院中医科；同济大学附属皮肤病医院药剂科）

出处： 复旦学报(医学版) 2025

关键词： 系统性红斑狼疮（SLE）；血小板减少症；环孢素；糖皮质激素；治疗药物监测

摘要： 系统性红斑狼疮（systemic lupus erythematosus，SLE）继发免疫性难治性血小板减少症（immune thrombocytopenia，ITP）以持续严重血小板减少和出血征象为主要特征，目前尚无标准的治疗方案。本例患者为34 岁男性，有10 余年贫血及血小板减少病史，入院后诊 ...

作者： 孙扬¹，黄燕欢¹，孙海明¹，余鑫铭²，倪花³，张骁晨¹，李玲¹，程文红^1,4，刘文敬¹ （¹上海交通大学医学院附属精神卫生中心儿少科；²滁州市第二人民医院儿童青少年心理科；³徐汇区精神卫生中心儿少科；⁴上海交通大学附属第一人民医院医学心理科）

出处： 中国儿童保健杂志 2025

关键词： 焦虑障碍；抑郁障碍；青少年；非自杀性自伤

摘要： 目的 研究儿童青少年焦虑障碍和抑郁障碍患者非自杀性自伤（NSSI）行为的特点，为临床干预提供理论基础。方法 采用方便抽样方法，自2019年10月—2023年10月在上海市精神卫生中心儿童青少年心理咨询门诊抽样135例有自伤行为的受试者进行调查。使用渥太华自我伤害问卷测量自伤方式和动机，儿童抑郁筛查量 ...

作者： （NMPA Key Laboratory for Quality Evaluation of Medical Protective and Implant Devices，Zhengzhou 450018，China；College of Biological Science and Medical Engineering，Donghua University，Shanghai 201620，China；Department of Orthopedics，Shanghai General Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 201620，China；School of Engineering，Westlake University，Hangzhou 310024，China；NMPA Key Laboratory for Quality Evaluation of Medical Protective and Implant Devices，Zhengzhou 450018，China；Henan Institute for Drug and Medical Device Inspection，Zhengzhou 450018，China；College of Biological Science and Medical Engineering，Donghua University，Shanghai 201620，China）

出处： 材料科学技术(英文版) 2025

关键词： Kirschner wire；Selenium；Calcium silicate；Antibacterial；Osteogenic

摘要： The Kirschner wire(K-wire)is widely used in orthopedic external fixation due to its versatility and clinical effectiveness.However,a significant chall ...

作者： （Center for Orthopaedic Science and Translational Medicine，Department of Orthopaedics，School of Medicine，Tongji University，Shanghai Tenth People's Hospital，Shanghai 200072，China；Department of Radiation Oncology，Shanghai General Hospital，Shanghai Jiaotong University，Shanghai 201600，China；Department of Orthopedics，Changzheng Hospital，Second Military Medical University(Naval Medical University)，Shanghai 200003，China；Suzhou First People's Hospital，School of Medicine，Anhui University of Science and Technology，Huainan 232001，China；Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases，Shanghai Stomatological Hospital&School of Stomatology，Fudan University，Shanghai 201102，China；Department of Orthopedics，Changzheng Hospital，Second Military Medical University(Naval Medical University)，Shanghai 200003，China；Translational Research Center of Orthopedics，Shanghai General Hospital，Shanghai Jiaotong University，Shanghai 200080，China；Center for Orthopaedic Science and Translational Medicine，Department of Orthopaedics，School of Medicine，Tongji University，Shanghai Tenth People's Hospital，Shanghai 200072，China；Suzhou First People's Hospital，School of Medicine，Anhui University of Science and Technology，Huainan 232001，China；Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases，Shanghai Stomatological Hospital&School of Stomatology，Fudan University，Shanghai 201102，China）

出处： 材料科学技术(英文版) 2025

关键词： Iron gallate；Hydrogel；Microsphere；Photothermal therapy；Tissue regeneration

摘要： Surgical incision infection is the most common postoperative complication that poses a serious threat to human health.In this work,the iron gallate(GA ...

作者： Liping Xiang，Bing Zhou，Yunchen Luo，Hanqi Bi，Yan Lu，Jian Zhou （Department of Endocrinology and Metabolism，Shanghai Clinical Center for Diabetes，Shanghai Diabetes Institute，Shanghai Key Laboratory of Diabetes Mellitus，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200233，China；Institute of Metabolism and Regenerative Medicine，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200233，China；Department of Endocrinology and Metabolism，Shanghai Clinical Center for Diabetes，Shanghai Diabetes Institute，Shanghai Key Laboratory of Diabetes Mellitus，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200233，China；Institute of Metabolism and Regenerative Medicine，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200233，China；Department of Endocrinology and Metabolism，Shanghai General Hospital Affiliated to Shanghai Jiao Tong University，Shanghai 200080，China；Institute of Metabolism and Regenerative Medicine，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200233，China；Institute of Metabolism and Regenerative Medicine，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200233，China；Department of Endocrinology and Metabolism，Shanghai Clinical Center for Diabetes，Shanghai Diabetes Institute，Shanghai Key Laboratory of Diabetes Mellitus，Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，Shanghai 200233，China）

出处： 中华医学杂志(英文版) 2025

关键词： Gluconeogenesis；Cytokines；Oxidative stress；Immune infiltration；Biomarkers；OMD；APOA4；IGFBP6

摘要： Background:Gluconeogenesis is a critical metabolic pathway for maintaining glucose homeostasis, and its dysregulation can lead to glycometabolic disor ...

作者： Chenkai Yang¹，Xiaoling Pan²，Weiguang Zhao¹，Zhiwen Qiu²，Lei He²，Cong Wu²，Ang Li²，Zhengnan Huang¹，Yilin Yan¹，Shengzhou Li³，Zhuofan Nan³，Xiangqian Cao³，Bing Shen^1,3，Wei Li² （¹Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University；²Department of Nanomedicine & Shanghai Key Lab of Cell Engineering, Naval Medical University；³Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine）

出处： Chinese Chemical Letters 2025

摘要： The induction of antitumor immunity by tumor antigens released from cancer cells following regional photothermal therapy(PTT) alone may not be adequat ...

作者： Huiyun Zhu，Qian Xue，Yingxiao Song，Zhenyu Zhang，Xing Li，Shengxiang Lyu，Qiang Zhan，Fei Liu，Lungen Lu，Liang Zhong，Weixing Chen，Dong Shao，Yanbing Ding，Deliang Liu，Xiaozhong Yang，Zhiming Huang，Zhaoshen Li，Yiqi Du （Department of Gastroenterology，Changhai Hospital of Navy Military Medical University，Shanghai 200433，China；Department of Gastroenterology，Changhai Hospital of Navy Military Medical University，Shanghai 200433，China；Department of Gastroenterology，Changhai Hospital of Navy Military Medical University，Shanghai 200433，China；Department of Gastroenterology，Nanjing First Hospital，Nanjing Medical University，Nanjing，Jiangsu 210012，China；Department of Gastroenterology，Pingxiang People’s Hospital，Pingxiang，Jiangxi 337055，China；Department of Gastroenterology，The First People’s Hospital of Lianyungang，Lianyungang，Jiangsu 222061，China；Department of Gastroenterology，Wuxi People’s Hospital，Wuxi，Jiangsu 214023，China；Department of Gastroenterology，Shanghai East Hospital，Shanghai 200120，China；Department of Gastroenterology，Shanghai First People’s Hospital，Shanghai 200080，China；Department of Gastroenterology，Huashan Hospital Affiliated to Fudan University，Shanghai 200000，China；Department of Gastroenterology，The First People’s Hospital of Yueyang，Yueyang，Hunan 414000，China；Department of Gastroenterology，The First People’s Hospital of Changzhou，Changzhou，Jiangsu 213003，China；Department of Gastroenterology，Yangzhou First People’s Hospital，Yangzhou，Jiangsu 225012，China；Department of Gastroenterology，The Second Xiangya Hospital of Central South University，Changsha，Hunan 410011，China；Department of Gastroenterology，Huai’an First People’s Hospital，Nanjing Medical University，Huai’an，Jiangsu 223300，China；Department of Gastroenterology，The First Affiliated Hospital of Wenzhou Medical University，Wenzhou，Zhejiang 325000，China；Department of Gastroenterology，Changhai Hospital of Navy Military Medical University，Shanghai 200433，China；Department of Gastroenterology，Changhai Hospital of Navy Military Medical University，Shanghai 200433，China）

出处： 中华医学杂志(英文版) 2025

关键词： Gastroesophageal reflux；Esophagitis；Tegoprazan；Esomeprazole；Non-inferiority trial

摘要： Background:An evidence gap still exists regarding the efficacy and safety of tegoprazan in patients with erosive esophagitis (EE) in China. This study ...

作者： 曹裕坤¹，叶娜¹，李铮²，周新丽¹ （¹上海理工大学健康科学与工程学院,生物系统热科学研究所；²上海交通大学附属第一人民医院临床泌尿外科中心/泌尿男科）

出处： 生物化学与生物物理进展 2025

关键词： 卵巢组织；玻璃化；海藻酸钠；水凝胶；纳米粒子；磁热复温

摘要： 目的 针对青春期前及急需治疗的恶性肿瘤患者,卵巢组织的冷冻和移植是更合适的生育力保存方法。目前临床上通常采用高浓度的低温保护剂（cryoprotectants,CPAs）进行卵巢组织冷冻并采用水浴进行复温,这会导致卵巢组织受到不同程度的毒性损伤和反玻璃化损伤。因此,本文基于海藻酸钠水凝胶包封及磁热复 ...

作者： 朱丹，王丹，夏敏，邹妮 （上海交通大学医学院附属上海市第一人民医院院感防控办公室）

出处： 中国感染控制杂志 2025

关键词： 新生儿；多重耐药菌； 社区获得性；耐甲氧西林金黄色葡萄球菌； 主动筛查

摘要： 目的 分析上海某三级综合医院新生儿病房不同来源新生儿细菌主动筛查结果,为新生儿感染预防与控制提供依据。方法 回顾性收集该院新生儿病房2017—2023年所有新生儿入院时主动筛查的监测结果,对比分析产科入院及社区入院新生儿细菌检出变化。结果 2017—2023年入院新生儿共有4 265例,其中产科来源 ...

作者： 王艳姣¹，王菁菁^2,3,4，倪梓涵²，戚紫怡^3,4，陈军^3,4，刘思辰^3,4，杨金柳行^3,4，杜林琳^3,4，何鲜桂^1,2,3,4 （¹上海中医药大学公共健康学院；²复旦大学医学院儿少卫生与妇幼保健教研室；³上海市眼病防治中心/同济大学附属眼科医院；⁴上海交通大学医学院附属上海市第一人民医院/国家眼部疾病临床医学研究中心）

出处： 中国学校卫生 2025

关键词： 运动活动；近视；回归分析；儿童；青少年

摘要： 目的 分析上海市不同学段儿童青少年周末户外活动现况及其对近视的影响，为制定更具针对性的近视防控方案提供依据。方法 2022年9—10月，采用分层整群随机抽样方法抽取上海市84所学校（27所幼儿园、21所小学、15所初中和21所高中）28 654名4～18岁儿童青少年纳入研究。通过眼科检查和问卷调查获 ...