王兴鹏
详细
作者： Cheng, Li;Zhao, Yan;Tang, Maochun;Luo, Zhengsheng;Wang, Xingpeng （1 Department of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, P.R. China 2 Department of Gastroenterology, School of Medicine, Shanghai Tenth People\'\'s Hospital, Tongji University, Shanghai 200072, P.R. China）
出处： Oncology Letters 2019 Vol.17 No.5 P4263-4270
关键词： apoptosis;cell migration;cell proliferation;isochorismatase domain-containing protein 1;pancreatic cancer
摘要： Pancreatic cancer is a deadly disease that is frequently associated with mortality at the time of diagnosis due to rapid metastasis, which makes it un ...
作者： Qixiang Mei;Yue Zeng;Chunlan Huang;Junyuan Zheng;Yuecheng Guo;Junjie Fan;Xinyuan Fu;Xingpeng Wang;Yingying Lu （1 Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, 201600, Shanghai, China 2 Department of Gastroenterology, Shanghai General Hospital, 201600, Shanghai, China）
出处： Inflammation 2020 Vol.43 No.4 P1510-1523
关键词： rapamycin;acute pancreatitis;endoplasmic reticulum stress;autophagy;hypertriglyceridemia
摘要： Hypertriglyceridemia (HTG) can aggravate acute pancreatitis (AP), but its pathogenesis remains unclear. As autophagic activity is closely related to l ...
作者： Bin Li;Jianghong Wu;Jingpiao Bao;Xiao Han;Shuangjun Shen;Xin Ye;Juanjuan Dai;Zengkai Wu;Mengya Niu;Yan He;Jianbo Ni;Li Wen;Xingpeng Wang;Guoyong Hu （Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Shanghai key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China）
出处： Biochimica et biophysica acta. Molecular basis of disease 2020 P165971
关键词： α7nAChR;autophagic flux;lysosomal degradation;acute pancreatitis;TFEB
摘要： Acute pancreatitis (AP) is associated with impaired acinar cell autophagic flux, intracellular zymogen activation, cell necrosis and inflammation. Act ...
作者： Qixiang Mei, Guoying Deng, Zehua Huang, Yue Yin, Chunlin Li, Junhui Hu, Yang Fu, Xingpeng Wang, Yue Zeng （Affiliations 1 Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China. 2 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）
出处： Frontiers in chemistry 2020 Vol.8 P720
关键词： Nrf2 signaling pathway;lung injury;oxidative stress;porous COS@SiO2 nanocomposites;severe acute pancreatitis.
摘要： Severe acute pancreatitis (SAP) is associated with high rates of mortality and morbidity. Chitosan oligosaccharides (COSs) are agents with antioxidant ...
作者： Shuangjun Shen, Bin Li, Juanjuan Dai, Zengkai Wu, Yan He, Li Wen, Xingpeng Wang, Guoyong Hu （Affiliations 1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）
出处： Frontiers in pharmacology 2020 Vol.11 P618
关键词： BRD4;SIRT1;acute pancreatitis;autophagic flux;lysosomal degradation.
摘要： Impaired autophagy has been shown to play a critical role in experimental and human acute pancreatitis (AP). However, the mechanism for transcriptiona ...
作者： Dai, Juanjuan1,2,3;He, Yan1,2;Jiang, Mingjie2,4;Niu, Mengya1,2;Li, Bin1,2;Wu, Zengkai1,2;Bao, Jingpiao1,2;Wen, Li1,2;Wang, Xingpeng1,2;Hu, Guoyong1,2 （1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 2 Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine 3 Department of Intensive Care Unit, State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine 4 Department of Head and Neck, State Key Laboratory of Oncology in South China, Sun Yat‐sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine）
出处： Journal of Cellular Physiology 2021 P1
关键词： ADM;Notch;Reg4;cell proliferation;pancreatic regeneration.
摘要： Pancreatic regeneration after acute pancreatitis is critical in the normal restoration of pancreatic exocrine function, the inhibition of which can ca ...
作者： Juanjuan Dai 1 2 , Mingjie Jiang 2 , Yangyang Hu 1 2 3 , Jingbo Xiao 1 2 , Bin Hu 1 2 , Jiyao Xu 4 , Xiao Han 1 2 , Shuangjun Shen 1 2 , Bin Li 1 2 , Zengkai Wu 1 2 , Yan He 1 2 , Yingchun Ren 1 2 , Li Wen 1 2 , Xingpeng Wang 1 2 , Guoyong Hu 1 2 （Affiliations 1 Department of Gastroenterology and. 2 Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 3 Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. 4 Department of Emergency, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.）
出处： JCI insight 2021 Vol.6 No.2 P138584
关键词： Epigenetics;Gastroenterology;Insulin;Molecular pathology;Therapeutics.
摘要： Severe acute pancreatitis (AP) is a life-threatening disease with up to 30% mortality. Therefore, prevention of AP aggravation and promotion of pancre ...
作者： Qi-Xiang Mei # 1 2 , Jun-Hui Hu # 1 2 , Ze-Hua Huang # 1 2 , Jun-Jie Fan 2 , Chun-Lan Huang 2 , Ying-Ying Lu 2 , Xing-Peng Wang 3 , Yue Zeng 4 （Affiliations 1 Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China. 2 Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China. 3 Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China. richardwangxp@163.com. 4 Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 201600, China. zengyue1592@yahoo.com.）
出处： Acta pharmacologica Sinica 2021 Vol.42 No.6 P942-953
关键词： chitosan oligosaccharides;gastrointestinal microbiome;inflammation;intestine;oxidative stress;pancreatitis.
摘要： Severe acute pancreatitis (SAP) is a severe acute abdominal disease. Recent evidence shows that intestinal homeostasis is essential for the management ...
作者： Zengkai Wu ,1 , 2;Xiao Han ,1 , 2;Jingpiao Bao ,1 , 2;Bin Li ,1 , 2;Jie Shen ,1 , 2;Pengli Song ,1 , 2;Qi Peng ,1 , 2;Xingpeng Wang ,1 , 2 and Guoyong Hu 1 , 2 （1Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China ; 2Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China）
出处： Oxidative Medicine and Cellular Longevity 2022
摘要： Acute pancreatitis (AP) is an inflammatory disease that is associated with trypsinogen activation, mitochondrial dysfunction, cell death, and inflamma ...
作者： Lanting Yu 1 2, Jiawei Lu 1 2, Haoran Xie 1 2, Jianbo Ni 1 2, Sumin Chen 3, Qiuyan Zhao 1 2, Ni Xie 1 2, Lungen Lu 1 2, Xingpeng Wang 1 2, Baiwen Li 1 2 （Affiliations 1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 2 Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 3 Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.）
出处： Journal of Cancer 2022
关键词： ARHGAP24;Pancreatic ductal adenocarcinoma;RELA;Transcription factor;microRNA.
摘要： Inflammation is one of the inducing factors of pancreatic ductal adenocarcinoma (PDAC), and microRNAs have been confirmed to be involved in the occurr ...
