发明人： 许毓鹏，刘堃，余奇，许迅

申请号： 201910195368.0

申请日期： 2019.03.14

摘要： 本申请涉及图像处理领域，公开了一种基于光学相干断层成像的降噪方法及其系统。该方法包括对多帧图像的各相邻帧进行帧间对齐；将该帧间对齐后的多帧图像进行邻域滤波；将该滤波后的多帧对齐图像进行降噪处理。本申请实施方式中能够较为有效的提取出多帧图像中的核心内容，同时去除噪声，对于整体图像的提取效果更佳。

发明人： 许迅，朱邵品

申请人： 上海市第一人民医院

申请号： 201810084222.4

申请日期： 2018.01.29

摘要： 本发明提供了一种预防和治疗纤维化的小分子多肽及其应用。本发明还涉及所述多肽的制法和应用以及含所述多肽的药物组合物。本发明多肽具有多种优点，例如分子量小，可透过各种眼组织屏障；水溶性好，能在中性泪液、房水和玻璃体液中保持较高的浓度等。

作者： Lu, Yi;Tai, Phillip W. L.;Ai, Jianzhong;Gessler, Dominic J.;Su, Qin;Yao, Xieyi;Zheng, Qiang;Zamore, Phillip D.;Xu, Xun;Gao, Guangping

出处： MOLECULAR THERAPY-NUCLEIC ACIDS 2018 Vol.10 P349-360

摘要： Corneal neovascularization (NV) is the major sight-threatening pathology caused by angiogenic stimuli. Current drugs that directly target pro-angiogen ...

作者： Wang, Jing;He, Xian-Gui;Xu, Xun

出处： INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2018 Vol.11 No.6 P1045-1052

摘要： The purpose of this article is to summarize the methods most commonly used to measure time spent outdoors and provide a comprehensive review of time a ...

作者： Li, Meng-Xiao;Yu, Su-Qin;Zhang, Wei;Zhou, Hao;Xu, Xun;Qian, Tian-Wei;Wan, Yong-Jing

出处： INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2019 Vol.12 No.6 P1012-1020

摘要： AIM: To explore a segmentation algorithm based on deep learning to achieve accurate diagnosis and treatment of patients with retinal fluid. METHODS: A ...

作者： Xu, Yupeng;Qu, Yuan;Suo, Yan;Gao, Jian;Chen, Xia;Liu, Kun;Xu, Xun

出处： BMC OPHTHALMOLOGY 2019 Vol.19

摘要： Backgrounds: To assess the changes in individual retinal layer thickness and visual function associated with gains in visual acuity after an intravitr ...

作者： Fu, Yang;Tang, Min;Xiang, Xiaoqiong;Liu, Kun;Xu, Xun

出处： Experimental & Therapeutic Medicine 2019 Vol.17 No.1 P273-283

关键词： diabetic retinopathy;human retinal capillary endothelial cells;secreted protein acidic and rich in cysteine;SPARC

摘要： The expression of secreted protein acidic and rich in cysteine (SPARC) has been recently identified to be associated with the pathology of diabetic re ...

作者： Xu, Yupeng;Deng, Guoying;Wang, Weiheng;Xiong, Shuyu;Xu, Xun

出处： ACTA OPHTHALMOLOGICA 2019 Vol.97 No.3 PE442-E447

摘要： Purpose The purpose of this study was to investigate the use of handheld digital devices and the prevalence of self-reported asthenopia among college ...

作者： Zhuang Y;Zhang J;Li Y;Gu H;Zhao J;Sun Y;Wang R;Zhang C;Chen W;Weng J;Qi L;Lu H;Zhang J;Liu Q;He Y;Xu X

出处： Endocrine, Metabolic & Immune Disorders Drug Targets 2019 Vol.19 No.3 P358-366

关键词： B lymphocytes;GDM;IgA;flow cytometry;immune;inflammation;insulin resistance

摘要： Backgroud: The present study aimed to investigate the association between immune cells and gestational diabetes mellitus (GDM) and identify a reasonab ...

作者： Xiu, Yanghui;Fan, Yuanrong;Wu, Kangni;Chen, Shuimiao;Pan, Meihua;Xu, Xun;Zhu, Yihua

出处： OPHTHALMIC GENETICS 2019 Vol.40 No.1 P66-68