上海市第一人民医院骨科是我院特色重点学科之一,有着悠久的历史和优良的文化传承。由我国外科和骨科奠基人任廷桂教授创立于解放初,是我国最早成立的骨科专业之一。于国内最先开展骶髂关节、髋关节结核病灶清除术。1961年刘广杰主任成立了国内最早的假肢研究室,开展伤残肢体医疗康复研究,同年成立了儿麻后遗症矫治医... [详细]
作者: 田雾,顾海涛,王莹,张航,孙红成,黄力,陈国庆,彭志海,钟林 (贵州省骨科医院普外科;上海交通大学附属第一人民医院肝胆胰外科;厦门大学附属翔安医院普外科)
出处: 中华普通外科杂志 2019
关键词: 胰腺肿瘤;胰十二指肠切除术;血管外科手术;预后
摘要: 目的 探讨胰十二指肠切除术(pancreaticoduodenectomy,PD)联合门静脉(portal vein,PV)/肠系膜上静脉(superior mesenteric vein,SMV)切除重建治疗胰腺癌并PV/SMV受侵的手术方式和临床价值.方法 回顾性对比分析2014年1月至2017 ...
作者: Xu, X.;Sang, W.;Liu, Y.;Zhu, L.;Lu, H.;Ma, J. (Department of Orthopedics, Shanghai General Hospital, No. 650 Xinsongjiang Road, Shanghai, 201620, China)
出处: Medical Principles and Practice 2018 Vol.27 No.5 P481-488
关键词: Aseptic inflammatory reaction;Inflammation index;Selective COX-2 inhibitor;Total knee arthroplasty
摘要: Objective: To evaluate the anti-inflammatory effectiveness of celecoxib and its effect on the rehabilitation of joint function after total knee arthro ...
发明人: 许婧,尹飞,王卓莹,华莹奇,蔡郑东
申请人: 上海市第一人民医院
申请号: 201810949725.3
申请日期: 2018.08.20
摘要: 本发明涉及一种富勒烯C60纳米晶体联合CaMKII抑制剂在骨肉瘤中的应用,所述应用在于通过联合C60纳米晶体与CaMKII抑制剂,增强C60纳米晶体杀伤骨肉瘤细胞的能力,降低C60纳米晶体的使用剂量。实验结果表明:(1)抑制CaMKIIα的活性可以增强C60纳米晶体杀伤骨肉瘤细胞的能力。(2)通过联 ...
发明人: 蔡郑东,孙伟,华莹奇,孙梦熊,沈嘉康,傅泽泽,马小军
申请人: 上海市第一人民医院
申请号: 201811174845.7
申请日期: 2018.10.09
摘要: 本发明涉及一种全骶骨假体,包括:底板;第一支板;第二支板;所述底板、所述第一支板和所述第二支板呈“∧”形设置;第一连接装置,所述第一支板和所述底板通过所述第一连接装置连接;第二连接装置,所述第二支板和所述底板通过所述第二连接装置连接;第一万向装置,所述第一万向装置与所述第一支板连接;第二万向装置,所 ...
发明人: 马春辉,王刚,吕琦,易诚青,腾松松
申请人: 上海市第一人民医院
申请号: 201810895773.9
申请日期: 2018.08.08
摘要: 本发明涉及一种滑膜间充质干细胞的软组织构建方法,所述方法通过滑膜间充质干细胞的分离与培养、滑膜间充质干细胞的鉴定、软组织的培养与分离、软骨分化能力检测四个步骤简单有效地制造出软组织并对软骨分化能力进行检测,从而达到有效修复软骨的目的。其优点在于:(1)本发明所构建的软组织具有良好的软骨分化能力,可为 ...
发明人: 王崇任,蔡郑东,华莹奇,孙伟,孙梦熊,傅泽泽,沈嘉康
申请人: 上海市第一人民医院
申请号: 201810865936.9
申请日期: 2018.08.01
摘要: 本发明涉及一种恶性肿瘤晚期肺转移伴恶性胸腔积液患者的肿瘤治疗方法,所述方法包括:于肺转移患者出现的癌性胸水中引流收集胸腔积液,离心富集后分离出转移性胸水中单核细胞(PEMC),调节浓度5×10 5 /ml于24孔板各孔,置于培养箱,用辐照后健康成人的外周血单核细胞(PBMC)与IL‑2联合应用扩增P ...
作者: Ying‐Ying Jiang;Zi‐Fei Zhou;Ying‐Jie Zhu;Fei‐Fei Chen;Bing‐Qiang Lu;Wen‐Tao Cao;Yong‐Gang Zhang;Zheng‐Dong Cai;Feng Chen (State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China;Department of Orthopedics, Spinal Pain Research Institute, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China;Department of Orthopedics, Spinal Pain Research Institute, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China;Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080 P. R. China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China;Department of Orthopedics, Spinal Pain Research Institute, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China;Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080 P. R. China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 P. R. China;Department of Orthopedics, Spinal Pain Research Institute, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, 200072 P. R. China)
出处: Small 2018 Vol.14 No.51
关键词: autophagy;biomineral;bone repair;enzymatic reaction;osteogenic differentiation
发明人: 华莹奇,王刚阳,蔡郑东,王卓莹,张涛,汪红胜,孙梦熊
申请人: 上海市第一人民医院
申请号: 201810058487.7
申请日期: 2018.01.22
摘要: 本发明涉及安罗替尼的新用途,属于药物技术领域,即安罗替尼抑制骨肉瘤生长和转移。其优点表现在:本发明首次发现安罗替尼可抑制骨肉瘤生长和转移。安罗替尼能够明显抑制骨肉瘤细胞系143B、U2OS、MG63和SJSA生长,诱导其周期阻滞,同时也能够抑制骨肉瘤细胞系迁移和侵袭。本发明首次发现安罗替尼能够增强化 ...
作者: Wen-cheng Lu,Yu-xiao Zhou,Ping Qiao,Jin Zheng,Qiang Wu,Qiang Shen (Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine;Center for Comparative Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Institute of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University;Department of Orthopedics, People’s Hospital of Zhangqiu)
出处: Neural Regeneration Research 2018 第3期 P427-433
摘要: In adult mammals,axon regeneration after central nervous system injury is very poor,resulting in persistent functional loss.Enhancing the ability of a ...
作者: Wang Jian;Wang Xiang;Cao Yun;Huang Tao;Song Deng-Xin;Tao Hai-Rong (Department of Orthopedics, Baoshan Branch of Shanghai First People\'s Hospital, Shanghai 200940, P.R. China. Department of Orthopaedics, Shanghai Ninth People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, P.R. China.)
出处: International journal of molecular medicine 2018
摘要: Knee osteoarthritis (OA) is the main cause of leg pain in middle‑aged and elderly individuals. Hyaluronic acid (HA), as well as curcuminoid, has been ...