上海市第一人民医院骨科是我院特色重点学科之一,有着悠久的历史和优良的文化传承。由我国外科和骨科奠基人任廷桂教授创立于解放初,是我国最早成立的骨科专业之一。于国内最先开展骶髂关节、髋关节结核病灶清除术。1961年刘广杰主任成立了国内最早的假肢研究室,开展伤残肢体医疗康复研究,同年成立了儿麻后遗症矫治医... [详细]
作者: 于召龙,王云浩,黄凯,晏鹏,田纪伟 (上海交通大学附属第一人民医院)
出处: 中国矫形外科杂志 2019
作者: Wujun Miao;Jiajia Chen;Lianshun Jia;Jun Ma;Dianwen Song (Department of Orthopedics, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China. Department of Orthopedics, Shanghai General Hospital of Nanjing Medical University, 650 Xinsongjiang Road, Shanghai, 201620, China;Department of Spine Surgery, The Second Affiliated Hospital of Nantong University, 6Haier Lane North Road, Nantong, Jiangsu, 226001, China. Department of Orthopedics, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China. Electronic address: jlsspine@smmu.edu.cn. Department of Orthopedics, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China. Electronic address: 491340827@qq.com. Department of Orthopedics, The First People\'s Hospital, Shanghai Jiao Tong University, 650 Xinsongjiang Road, Shanghai, 201620, China;Department of Orthopedics, Shanghai General Hospital of Nanjing Medical University, 650 Xinsongjiang Road, Shanghai, 201620, China. Electronic address: sdwhai123@163.com.)
出处: Biochemical and biophysical research communications 2019
关键词: LEF1;METTL3;Osteosarcoma;m6A
摘要: Osteosarcoma(OS) is the most common and aggressive malignant bone sarcoma,which occurs in rapidly growing bones in children and adolescents. However, ...
作者: Fei Yin;Zongyi Wang;Yafei Jiang;Tao Zhang;Zhuoying Wang;Yingqi Hua;Zhiming Song;Jianhua Liu;Weiguo Xu;Jing Xu;Zhengdong Cai;Jianxun Ding (c Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, PR China a Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Bone Tumor Institution, 100 Haining Street, Shanghai 200080, PR China d Jilin Biomedical Polymers Engineering Laboratory, 5625 Renmin Street, Changchun 130022, PR China b Department of Sports Medicine, The First Hospital of Jilin University, 71 Xinmin Street, Changchun 130021, PR China)
出处: Nanomedicine: Nanotechnology, Biology and Medicine 2019 P102085
关键词: Polypeptide micelle;Reduction responsiveness;Antineoplastic agent delivery;Osteosarcoma therapy;Lung metastasis inhibition
摘要: Osteosarcoma (OS) is the most common malignant bone tumor with high metastasis and mortality. Neoadjuvant chemotherapy is an effective therapeutic reg ...
作者: Zhenlin Wang;Mengchen Yin;Peilin Chu;Meiqing Lou (Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Orthopaedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Department of Orthopedics, The Central Hospital of Ma An Shan City, Anhui, China.)
出处: Aging 2019 Vol.11
关键词: AZ628;BP-1-102;RAF;STAT3;lung cancer harboring KRAS mutations
摘要: KRAS is frequently mutated in patients with lung cancers, resulting in low survival rates. Inhibiting the downstream pathways of KRAS seems to be a fe ...
作者: 于召龙,王云浩,朱文峰,田纪伟 (上海交通大学附属第一人民医院骨科;上海邮电医院骨科)
出处: 国际检验医学杂志 2019
关键词: 钠离子;椎间盘退变;细胞外基质;渗透压;钠-钾ATP酶
摘要: 目的探讨不同浓度钠离子对培养的人椎间盘髓核细胞基质组分的影响及可能机制。方法分离、培养并鉴定人椎间盘髓核细胞后,根据培养基钠离子不同浓度分为4组,将完全培养基(Na+150 mmol/L)设为对照组,其余不同浓度培养基溶液(分别为200 mmol/L、225 mmol/L、250 mmol/L)设为 ...
作者: 董自强,赵改平,邢峰,杨加静,毕厚海,许海飞,赵庆华,王宏杰 (上海理工大学医疗器械与食品学院;内蒙古包头市达茂联合旗医院麻醉科;上海市第一人民医院骨科)
出处: 生物医学工程学进展 2019 第3期 P136-141
关键词: 横韧带损伤;上颈椎;关节活动度;应力分布
摘要: 目的 建立寰椎横韧带损伤上颈椎C0-C3不稳定节段的三维有限元模型,探究横韧带损伤对上颈椎关节活动度ROM(the range of motion)和椎骨应力分布的影响。方法 基于CT图像数据结合临床寰椎横韧带损伤特征,建立人体寰椎横韧带损伤上颈椎不稳定的三维有限元模型,比较分析横韧带损伤后上颈椎在 ...
作者: 金新蒙,杨铁毅,王雷 (第二军医大学附属公利医院骨科;上海交通大学附属第一人民医院骨科)
出处: 中华骨与关节外科杂志 2019
作者: 鲁兴,张国栋,褚楷,张泽 (烟台市烟台山医院创伤一科;烟台市烟台山医院运动医学科;上海市第一人民医院骨科)
出处: 中华实验外科杂志 2019
关键词: 17β-雌二醇;骨髓间充质干细胞;成骨细胞;分化
摘要: 目的 观察17β-雌二醇在骨髓间充质干细胞(BMSCs)向成骨细胞分化中的作用.方法 将诱导分化后的BMSCs分为对照组及17β-雌二醇组(1×10-10、1×10-9、1×10-8 mol/L的17β-雌二醇),在诱导第7天,测定碱性磷酸酶(ALP)活性,细胞活力,Wnt1、Wnt10b及β-连环 ...
作者: 薛豹,桑伟林,姜亚飞,马金忠 (上海交通大学附属第一人民医院骨科)
出处: 现代生物医学进展 2019
关键词: 橙皮素;软骨细胞;骨性关节炎;脂多糖
摘要: 目的:炎症因子所介导的慢性炎症瀑布反应是引起关节软骨退变的的主要原因。橙皮素具有抗炎、抗氧化应激等作用,研究橙皮素对关节软骨细胞炎症因子表达及相关信号通路的影响可以加深对关节软骨退变的认识,进而为其预防、治疗提供新的参考依据。研究橙皮素对人关节软骨细胞退变的影响,并从炎症角度来探讨其具体的分子机制。 ...
作者: 薛豹,桑伟林,姜亚飞,马金忠 (上海交通大学附属第一人民医院骨科)
出处: 现代生物医学进展 2019
关键词: 橙皮素;软骨细胞;骨性关节炎;脂多糖
摘要: 目的:炎症因子所介导的慢性炎症瀑布反应是引起关节软骨退变的的主要原因。橙皮素具有抗炎、抗氧化应激等作用,研究橙皮素对关节软骨细胞炎症因子表达及相关信号通路的影响可以加深对关节软骨退变的认识,进而为其预防、治疗提供新的坝考依据。研究橙皮素对人关节软骨细胞退变的影响,并从炎症角度来探讨其具体的分子机制。 ...