上海市第一人民医院骨科是我院特色重点学科之一，有着悠久的历史和优良的文化传承。由我国外科和骨科奠基人任廷桂教授创立于解放初，是我国最早成立的骨科专业之一。于国内最先开展骶髂关节、髋关节结核病灶清除术。1961年刘广杰主任成立了国内最早的假肢研究室，开展伤残肢体医疗康复研究，同年成立了儿麻后遗症矫治医... [详细]
作者： Zhongzheng Zhi;Chenglin Zhang;Jian Kang;Yingjie Wang;Jingdong Liu;Furong Wu;Guanghui Xu （Department of Orthopedics, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China;Department of Orthopedics, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;Department of Orthopedics, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;Department of Orthopedics, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;Shanghai Clinical Research Center for Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;Guanghui Xu, Department of Orthopedics, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, No. 1878 North Sichuang Road, Hongkou District, Shanghai 200081, China.;Department of Orthopedics, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China;Guanghui Xu, Department of Orthopedics, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, No. 1878 North Sichuang Road, Hongkou District, Shanghai 200081, China.）
出处： Journal of Cellular Physiology 2020 Vol.235 No.10 P7173-7182
关键词： bone marrow–derived mesenchymal stem cells;chondrocyte;hypoxia;KDM6A;osteoarthritis;SOX9
摘要： Abnormal expression of KDM6A and SOX9 is a key factor in the pathogenesis of osteoarthritis (OA). Cellular treatments of OA with articular cartilage c ...
作者： Qing Shao;Song Xue;Yafei Jiang;Haiming Lu;Weilin Sang;Cong Wang;Bao Xue;Yu Liu;Libo Zhu;Jinzhong Ma （Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address: majinzhong1963@sina.com.）
出处： International immunopharmacology 2020
关键词： Cartilage;Esculentoside A;Inflammation;Osteoarthritis;Osteoclastogenesis;Subchondral bone
摘要： Osteoarthritis is a relatively common disorder of articular deterioration related to cartilage damage, subchondral bone remodelling, inflammation and ...
作者： Jian Kang;Chenglin Zhang;Zhongzheng Zhi;Yingjie Wang;Jingdong Liu;Furong Wu;Guanghui Xu （Department of Orthopedics, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China; Department of Orthopedics, School of Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China; Department of Orthopedics, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China; Department of Orthopedics, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China; Department of Orthopedics, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China; Shanghai Clinical Research Center for Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Department of Orthopedics, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai, China）
出处： Artificial Cells, Nanomedicine, and Biotechnology 2020 Vol.48 No.1 P627-638
关键词： Spinal cord injury;apoptosis;miR-29b;PTEN;caspase-3
摘要： We aimed to evaluate the therapeutic effects of exosomes, which were collected from human neuroepithelial stem cells (HNESCs) treated by miR-29b mimic ...
作者： 薛松，姜亚飞，桑伟林，马金忠 （上海交通大学附属第一人民医院骨科）
出处： 中国矫形外科杂志 2020
关键词： 骨关节炎；软骨细胞；肥大；作用机制
摘要： 骨关节炎(osteoarthritis, OA)现已成为危害全球老龄人群身心健康的重要疾病之一。软骨细胞的肥大改变在骨性关节炎中较常出现,肥大软骨细胞表达一些较为典型的生物学标志,进而介导OA的不断进展;软骨细胞肥大化涉及多条分子信号通路的调控,包括Wnt、TGF-β、IHH/PTHrP等主要信号通 ...
作者： 于召龙，梁鹤，李秋园，田纪伟 （上海交通大学附属第一人民医院骨科）
出处： 脊柱外科杂志 2020
关键词： 骶骨；肝肿瘤；肿瘤转移
摘要： 肝癌位居世界常见恶性肿瘤第6位,其死亡率居第3位,绝大多数为肝细胞癌(HCC)。近年来,肝癌诊断和治疗策略有所改善,患者生存时间得到延长,但5年生存率仍较低(16%),若发生肝外转移,生存率仅为4%[1-2]。有文献报道,HCC肝外转移发生率为15%～17%[3],除转移至肺、淋巴结、肾等,还可转移 ...
作者： 郑龙坡，胡传真，贺石生，张长青，蔡郑东，纪方，王蕾，禹宝庆，董宇启，陈文钧，罗涛，唐昊 （同济大学附属第十人民医院骨科；上海交通大学附属第六人民医院骨科；上海交通大学附属第一人民医院骨科；上海交通大学附属第九人民医院骨科；上海交通大学附属瑞金医院骨科；复旦大学附属浦东医院骨科；上海交通大学附属仁济医院骨科；复旦大学附属华山医院骨科；复旦大学附属公共卫生临床中心；海军军医大学附属长海医院骨科）
出处： 中华骨与关节外科杂志 2020 第2期 P109-113
关键词： 新型冠状病毒肺炎；创伤骨科；防护
摘要： 由于新型冠状病毒肺炎(COVID-19)潜伏期长,早期症状无特异性,以往针对严重急性呼吸综合征冠状病毒(SARS-CoV)的筛查和防护手段已经不能满足COVID-19疫情控制的需求,必须对COVID-19进行全新的认识并采取特殊的处理流程。由于骨科创伤、出血及疼痛等急性症状的掩盖,COVID-19疫 ...
作者： Songsong Teng;Chunhui Ma;Yinxian Yu;Chengqing Yi （Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）
出处： Biosci Rep 2019
关键词： cancer;cell apoptosis;cell cycle;hydroxyurea;TET1
摘要： Ten-eleven translocation (TET) proteins are abnormally expressed in various cancers. Osteosarcoma cells were treated with hydroxyurea to investigate t ...
作者： Xinmeng Jin;Congcong Wang;Lei Wang （Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: thunderwang@126.com.）
出处： Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Vol.121 P109659
关键词： Costunolide;STAT3;growth and metastasis;osteosarcoma
摘要： Costunolide, an active sesquiterpene lactone, is derived from a number of medicinal plants and it exhibits a broad spectrum of bioactivities such as a ...
作者： 刘钰莹，孙伟 （上海交通大学附属第一人民医院耳鼻咽喉头颈外科 2纽约州立布法罗大学听力与聋病中心）
出处： 中华耳科学杂志 2019
作者： 华莹奇 （上海市第一人民医院）
出处： 中国医学人文 2019
摘要： 每天上下班,开车会路过上海市的西宝兴路火葬场,作为医生,倒不是特别忌讳。有一次坐出租车,发现司机特意绕路避开了那段,问他原因,司机回答:“我从不走那条路的。”中国人,一向是很忌讳死亡的。中西差别平静接受VS不愿放弃在美国学习的时候,有一次门诊时,遇到一位腹腔巨
