【卷号】NAT DONG HWA UNIV;SHANGHAI FIRST PEOPLE'S HOSPITAL
【页码】CN105561345;|2016.05.11
【ISSN】CN2016100525460
【分类号】A61K49/04
【摘要】The invention relates to a preparation method of hollow mesoporous silica loaded by nanometer star-shaped gold particles. The method includes the steps of forming solid silicon wrapped by meso-porous silicon in an ethyl alcohol, ultrapure water and ammonia mixed solution with ethyl orthosilicate as a silicon source, etching the solid silicon through sodium carbonate to form hollow mesoporous silica, modifying the surface of the hollow mesoporous silica by sulfydryl and loading the surface of the hollow mesoporous silica with nanometer gold particles so that the hollow mesoporous silica can serve as seeds, making the seeds grow into the hollow mesoporous silica loaded by nanometer star-shaped gold particles in a chloroauric acid solution, and wrapping perfluorohexane and modifying polyethylene glycol with one end being -SH. The prepared nanometer particles have excellent biocompatibility and long in-vivo blood circulation time, have good US/CT/PA imaging and photo-thermal treatment effects and are wide in application prospects, and a new method is provided for development of multi-mode imaging contrast media and treatment integrated platforms.
