【卷号】THE FIRST PEOPLE'S HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV;NAT DONG HWA UNIV
【页码】CN105617412;|2016.06.01
【ISSN】CN2014107175543
【分类号】A61K51/06
【摘要】The invention belongs to the field of medical imaging contrast agents, and in particular relates to a preparation method of a different surface-modified SPECT/CT dual-mode imaging contrast agent based on PEGylated polyethyleneimine (PEI). The preparation method comprises the following steps: firstly, modifying the surface of PEI with a radionuclide Tc chelating agent DTPA, further modifying with mPEG-COOH activated by EDC, so as to obtain functional PEI synthesizing functional PEI coated gold nanoparticles by using the in-situ reduction method, and performing acetylization or hydroxylation on amino groups remained on the surfaces finally, marking Tc to obtain the SPECT/CT dual-mode imaging contrast agent. The different surface-modified SPECT/CT dual-mode imaging contrast agent based on PEI has an excellent SPECT/CT imaging effect besides, tests show that SPECT/CT imaging of different tissues in a mouse body can be realized, a solid foundation is laid for development of a novel functional tissue specific contrast agent, and the application prospect is broad.
