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  • Preparation method of curcumin-polyvinylpyrrolidone composite nanofiber solid dispersion

  • 【作者】ZHAO QINGHUA;ZHANG YONGXING;WANG CHUAN
  • 【年份】2015
  • 【卷号】FIRST PEOPLE S HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY
  • 【页码】CN104983670;|2015.10.21
  • 【ISSN】CN2015104142275
  • 【分类号】A61K9/00
  • 【摘要】The invention discloses a preparation method of a curcumin-polyvinylpyrrolidone composite nanofiber solid dispersion, which comprises the steps of step 1, respectively weighing polyvinylpyrrolidone and an organic solvent and uniformly stirring, wherein the mass ratio of the polyvinylpyrrolidone to the organic solvent is (0.5-1.5g):10ml, and the organic solvent is dimethylformamide or ethyl acetate step 2, weighing curcumin, adding into the obtained mixed solution, uniformly mixing through an ultrasound or stirring manner and preparing a spinning solution, wherein the mass ratio of the polyvinylpyrrolidone to the curcumin is (10-15):4 step 3, electro-spinning the spinning solution by adopting an electrostatic spinning process, and collecting a product. The preparation method of the curcumin-polyvinylpyrrolidone composite nanofiber solid dispersion is simple in process, low in device requirements, easy to operate, low in cost and capable of being widely applied in fast dissolving and release of the curcumin.
  • 【文献类型】外文专利

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