【卷号】SHANGHAI JIAOTONG UNIVERSITY AFFILIATED FIRST PEOPLE S HOSPITAL
【页码】2012.10.03
【ISSN】CN2011100740089
【分类号】G01N33/66
【摘要】The present invention belongs to the field of bio-medicine, relates to a liver fibrosis serum N-glycome peak mark, and specifically relates to a method for detecting the chronic hepatitis B liver fibrosis serum N-glycome peak mark and the application thereof. The method detects a serum sample of a chronic HBV infected patient by using DSA-FACE technology to obtain a glycome map with peak values. After the peak values are quantified, the non-traumatic chronic hepatitis B liver fibrosis serum N-glycome peak mark is obtained by using the internal reference corrected data. The method of the invention can help to significantly improve the specificity and the sensitivity of non-traumatic diagnosis for chronic hepatitis B liver fibrosis, can help to efficiently predict the degree of liver fibrosis in chronic hepatitis B with the N-glycome peak mark as a non-traumatic alternative indicator, and has clinical significance in reality for prognosis estimation, treatment option and treatment evaluation.
