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  • Biodegradable polymer braided stone-dissolving bile duct stent and preparation method thereof

  • 【作者】XINJIAN WAN;QING YANG;PEIHUA ZHANG;WEIXING ZHANG;CUIHONG SHI;HUIYING ZHEN
  • 【年份】2012
  • 【卷号】SHANGHAI FIRST PEOPLE S HOSPITAL
  • 【页码】2012.10.17
  • 【ISSN】CN2012100289046
  • 【分类号】A61L31/10
  • 【摘要】The invention, belonging to the field of biomedicine and bio-polymer material, particularly relates to a biodegradable polymer braided stone-dissolving bile duct stent and a preparation method thereof. The stent is prepared by braiding biodegradable polymers to obtain a porous reticulated or spiral tubular braided stent, and then coating a biodegradable drug loaded substance layer containing sodium cholate or/and edetate disodium on the inner surface and outer surface of the braided stent. Clinical outcomes show that the stone-dissolving bile duct stent of the invention has good radial supporting performance, can keep the bile duct open, can be degraded away in a certain time, has good biocompatibility, and lets almost no internal inflammation generate. Simultaneously, sodium cholate or/and edetate disodium slowly released by the polymer layer containing drugs can dissolve the formed stones and can prevent the re-formation of stones.
  • 【文献类型】外文专利

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