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  • HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis

  • 【作者】Yu, Fujun;Chen, Bicheng;Dong, Peihong;Zheng, Jianjian
  • 【作者单位】a Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China; b Department of Gastroenterology, Songjiang Hospital Affiliated Shanghai First People\'s Hospital, Shanghai Jiao Tong University, Shanghai, 201600, China; c Department of Gastroenterology, Shanghai Songjiang Hospital Affiliated to Nanjing Medical University, Nanjing, 210029, China; d Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China
  • 【出处】MOLECULAR THERAPY
  • 【年份】2017
  • 【卷号】Vol.25 No.1
  • 【页码】205-217
  • 【关键词】DNA methylation;DNA methyltransferase;DNMT;homeobox transcript antisense RNA;HOTAIR;microRNA-29b;phosphatase and tensin homolog deleted on chromosome 10;PTEN
  • 【ISSN】1525-0016;1525-0016
  • 【分类号】572.8
  • 【摘要】Homeobox transcript antisense RNA (HOTAIR), as a long intergenic non-coding RNA (lincRNA), is upregulated in various cancers and involved in diverse cellular functions. However, its role in liver fibrosis is unclear. In this study, HOTAIR expression was u
  • 【文献类型】外文期刊

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