【作者单位】;[ 1 ] Shanghai Jiao Tong Univ, Sch Med, Affiliated Peoples Hosp 1, Shanghai 200030, Peoples R China
【出处】FEBS Letters
【年份】2014
【卷号】Vol.588 No.18
【页码】3333-3339
【关键词】Drug resistance;Glioma;PDCD4
【ISSN】0014-5793
【分类号】572
【摘要】Understanding the resistance of glioma cells to chemotherapy has been an enormous challenge. In particular, mechanisms by which tumor cells acquire resistance to chemotherapy under hypoxic conditions are not fully understood. In this study, we have found that miR-497 is overexpressed in glioma and that hypoxia can induce the expression of miR-497 at the transcriptional level by binding with the hypoxia response element in the promoter. Ectopic overexpression of miR-497 promotes chemotherapy resistance in glioma cells by targeting PDCD4, a tumor suppressor that is involved in apoptosis. In contrast, the inhibition of miR-497 enhances apoptosis and increases the sensitivity of glioma cells to TMZ. These results suggest that miR-497 is a potential molecular target for glioma therapy.
