作者： Zhiwei Qin¹;Chongzhi Zhou¹CA1 （1 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, China）

出处： Experimental Hematology & Oncology 2022 Vol.11 No.1

关键词： Gastric cancer;HOXA13;FN1;FAK/Src;miR-449a

摘要： Background Gastric cancer (GC) is one of the most common cancers causing a poor prognosis worldwide. HOXA13, as a member of the homeobox (HOX) family ...

作者： Ming Wang  ¹, Yangmei Xie  ¹, Yiye Shao  ², Yinghui Chen  ¹ （Affiliations 1 Department of Neurology, Huashan Hospital, Fudan University. 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine.）

出处： Biological & pharmaceutical bulletin 2022 Vol.45 No.1 P86-93

关键词： inflammation;microglia;nuclear factor-kappaB (NF-κΒ) signaling pathway;small nucleolar RNA host gene 5;status epilepticus.

摘要： Status epilepticus (SE) induced inflammation plays an important role in the pathogenesis of SE. Long non-coding RNA small nucleolar RNA host gene 5 (l ...

作者： Lingling Zhuang  ¹, Xu Ming  ², Jun Liu  ², Chao Jia  ¹, Yubiao Jin  ³, Jing Wang  ³, Qiusheng Shi  ¹, Rong Wu  ¹, Lifang Jin  ¹, Lianfang Du  ¹ （Affiliations 1 Department of Medical Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 2 Department of Breast-Thyroid-Vascular Surgery, Shanghai General Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China. 3 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.）

出处： The British journal of radiology 2022 Vol.95 No.1130 P20210897

摘要： Objectives: This study aimed to compare diagnostic efficiency for axillary sentinel lymph node (SLN) metastasis between lymphatic contrast-enhanced ul ...

作者： Siteng Chen ^{#  1}, Encheng Zhang ^{#  1}, Tuanjie Guo ^{#  1}, Jialiang Shao  ¹, Tao Wang  ¹, Ning Zhang  ², Xiang Wang  ³, Junhua Zheng  ⁴ （Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zn12235@rjh.com.cn. 3 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. seanw_hs@163.com. 4 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhengjh0471@sina.com.）

出处： BMC cancer 2022 Vol.22 No.1 P1

关键词： Cell cycle;Clear cell renal cell carcinoma;Ferroptosis;Nomogram;Prognosis.

摘要： Background: It is of great urgency to explore useful prognostic markers for patients with clear cell renal cell carcinoma (ccRCC). Prognostic models b ...

作者： Yuan Yuan ^{#  1}, Guangjian Fan ^{#  2}, Yuqi Liu ^{#  1}, Lu Liu  ³, Tong Zhang  ¹, Pengfei Liu  ¹, Qing Tu  ¹, Xinyi Zhang  ¹, Shiyuan Luo  ⁴, Liangfang Yao  ⁵, Feng Chen  ⁶, Jingbao Li  ⁷ （Affiliations 1 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 201620, China. 2 Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 201620, China. 3 Department of Anesthesiology, Weifang Medical University, Weifang, 261000, China. 4 Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 5 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 201620, China. yao_elina@163.com. 6 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 201620, China. smmuchenfeng@163.com. 7 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 201620, China. lijingbaoshanghai@163.com.）

出处： Cellular & molecular immunology 2022

关键词： Glycolysis;HK2;KLF14;Macrophages;Perhexiline;Sepsis.

摘要： Sepsis is a heterogeneous syndrome induced by a dysregulated host response to infection. Glycolysis plays a role in maintaining the immune function of ...

作者： Ling Shen  ¹, Peng Gu  ², Chen Qiu  ³, Wen-Tao Ding  ², Lei Zhang  ⁴, Wan-Yue Cao  ², Zu-Yin Li  ⁵, Bin Yan  ⁶, Xing Sun  ⁷ （Affiliations 1 Clinical Medical School, Shanghai General Hospital of Nanjing Medical University, Shanghai, China; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Institute of Gallstone Disease, Center of Gallbladder Disease, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. 4 Intervention Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Hepatobiliary Surgery, Peking University Organ Transplantation Institute, Peking University People\'s Hospital, Beijing, China. 6 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yanbin8988@sjtu.edu.cn. 7 Clinical Medical School, Shanghai General Hospital of Nanjing Medical University, Shanghai, China; Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: xingsun_sjtu@aliyun.com.）

出处： Annals of hepatology 2022 P100680

关键词： EMT;Hepatocellular carcinoma;LPCAT1;Migration and invasion;Wnt/β-catenin pathway.

摘要： Introduction and objectives: Hepatocellular carcinoma (HCC) is one of the most malignant digestive tumors, and its insidious onset and rapid progressi ...

作者： Binghang Li  ¹, Fei Li  ¹, Tianyi Gu  ¹, Yuecheng Guo  ¹, Bo Shen  ¹, Xianjun Xu  ¹, Zhenyang Shen  ¹, Liuying Chen  ², Qidi Zhang  ¹, Hui Dong  ¹, Xiaobo Cai  ³, Lungen Lu  ⁴ （Affiliations 1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China; Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China. 2 Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. 3 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China; Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China. Electronic address: caixiaobo19790719@126.com. 4 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China; Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China. Electronic address: lungenlu1965@163.com.）

出处： European journal of pharmacology 2022 P174866

关键词： Hepatic progenitor cell;Liver fibrosis;Y-box binding protein 1;p53.

摘要： The proliferation of hepatic progenitor cells (HPCs) contributes to liver regeneration and fibrogenesis during chronic liver injury; however, the mech ...

作者： Qidi Zhang ^{#  1}, Ying Qu ^{#  1}, Qingqing Zhang  ², Fei Li  ¹, Binghang Li  ¹, Zhenghong Li  ¹, Yuwei Dong  ¹, Lungen Lu  ³, Xiaobo Cai  ⁴ （Affiliations 1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 650 New Songjiang Road, Shanghai, 201620, China. 2 Department of Gastroenterology, Ruian People\'s Hospital, No. 108 Wansong Road, Ruian, 325200, China. 3 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 650 New Songjiang Road, Shanghai, 201620, China. lungenlu1965@163.com. 4 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 650 New Songjiang Road, Shanghai, 201620, China. caixiaobo1979@hotmail.com.）

出处： Cell biology and toxicology 2022

关键词： Exosome;Fe2+;Ferroptosis;Hepatic stellate cell;Hepatitis B virus;Hepatocytes;Lipid ROS;Liver fibrosis;Transferrin receptor;miR-222.

摘要： Exosomal miRNAs activates hepatic stellate cell (HSC) and promote fibrosis. miR-222 was found to be increased in hepatitis B virus (HBV)-infected hepa ...

作者： Mingjun Ma  ¹, Jingfen Zhu  ², Yongbin Yang  ¹, Xiaoyun Wang  ¹, Yubiao Jin  ³, Jiawen Zhang  ^{1   4}, Sufang Wu  ¹ （Affiliations 1 Department of Obstetrics and Gynecology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China. 2 School of Public Health, Shanghai Jiao Tong University, Shanghai, P.R. China. 3 Department of Pathology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China. 4 Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China.）

出处： Cancer medicine 2022

关键词： CIN;HPV genotypes;HPV vaccine;cervical lesions;risk factors.

摘要： Human papillomavirus (HPV) infection is the main cause of female precancerous lesions and cervical cancer. The development and application of HPV prop ...

作者： Peng Xu  ¹, Shaobo Zhang  ¹, Lili Tan  ², Lei Wang  ², Zhongwei Yang  ¹, Jinbao Li  ¹ （Affiliations 1 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Anesthesiology, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, China.）

出处： Frontiers in oncology 2022 Vol.12 P836882

关键词： anticancer;drug repurposing;local anesthetics;mechanisms;ropivacaine.

摘要： Despite the significant progress in cancer treatment, new anticancer therapeutics drugs with new structures and/or mechanisms are still in urgent need ...