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作者: Jinxi Li1,2,3;James D. Glover4,3;Haiguo Zhang5,3;Meifang Peng2,5,3,6;Jingze Tan5;Chandana Basu Mallick4,7;Dan Hou8;Yajun Yang5;Sijie Wu1,2;Yu Liu2;Qianqian Peng2;Shijie C. Zheng2;Edie I. Crosse9;Alexander Medvinsky9;Richard A. Anderson10;Helen Brown4;Ziyu Yuan11;Shen Zhou12;Yanqing Xu13;John P. Kemp14;Yvonne Y.W. Ho15;Danuta Z. Loesch16;Lizhong Wang17;Yingxiang Li17;Senwei Tang17;Xiaoli Wu17;Robin G. Walters18,19;Kuang Lin18;Ruogu Meng20;Jun Lv21;Jonathan M. Chernus22;Katherine Neiswanger23;Eleanor Feingold22;David M. Evans14,24,25;Sarah E. Medland15;Nicholas G. Martin15;Seth M. Weinberg22,23,26;Mary L. Marazita22,23,27,28;Gang Chen17;Zhengming Chen18,19;Yong Zhou29;Michael Cheeseman4;Lan Wang8;Li Jin1,2,30,31CA1;Denis J. Headon4,31CA2;Sijia Wang2,32,31,33CA3 (1 State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200438, PRC; 2 CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC; 3 These authors contributed equally; 4 The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK; 5 Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PRC; 6 Present address: The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostics and Endocrinology, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PRC; 7 Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India; 8 Chinese Academy of Sciences Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC; 9 Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK; 10 MRC Centre for Reproductive Health, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK; 11 Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu 225326, PRC; 12 Shanghai Foreign Language School, Shanghai 200083, PRC; 13 Forest Ridge School of the Sacred Heart, Bellevue, WA 98006, USA; 14 University of Queensland Diamantina Institute, University of Queensland, Brisbane, QLD, Australia; 15 QIMR Berghofer Medical Rese Institute, Brisbane, QLD, Australia; 16 Psychology Department, La Trobe University, Melbourne, VIC, Australia; 17 WeGene, Shenzhen, Guangdong 518040, PRC; 18 Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; 19 Medical Research Council Population Health Research Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; 20 Center for Data Science in Health and Medicine, Peking University, Beijing 100191, PRC; 21 Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, PRC; 22 Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA; 23 Center for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, University of Pittsburgh, Pittsburgh, PA 15219, USA; 24 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; 25 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK; 26 Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA; 27 Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA 15261, USA; 28 Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA; 29 Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PRC; 30 Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058), Chinese Academy of Medical Sciences, Shanghai 200438, PRC; 31 Senior author; 32 Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, PRC; 33 Lead contact)

出处: Cell 2022 Vol.185 No.1 P95-112(e18)

关键词: fingerprint pattern;genetics;genome-wide association study;trans-ethnic meta-analysis;limb development;EVI1

摘要: Fingerprints are of long-standing practical and cultural interest, but little is known about the mechanisms that underlie their variation. Using genom ...

作者: Xueyu Chen;Fengxue Shi;Juan Xiao;Fengyan Huang;Fang Cheng;Lihua Wang;Yanli Ju;Yong Zhou;Hongying Jia;Hongying Jia (Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Clinical Skills Center, School of Clinical Medicine, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China Center of Evidence-Based Medicine, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China Center of Evidence-Based Medicine, Institute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China)

出处: Frontiers in Endocrinology 2022 Vol.13

关键词: CVAI;NAFLD;abdominal obesity;visceral adiposity;abdominal obesity indices

摘要: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver metabolic disease worldwide. Up to 70%–80% of patients with NAFLD were obese, espe ...

作者: Chenyu Sun;Shaodi Ma;Yue Chen;Na Hyun Kim;Sujatha Kailas;Yichen Wang;Wenchao Gu;Yisheng Chen;John Pocholo W. Tuason;Chandur Bhan;Nikitha Manem;Yuting Huang;Ce Cheng;Ce Cheng;Zhen Zhou;Qin Zhou;Yanzhe Zhu (AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China Department of Clinical Medicine, School of the First Clinical Medicine, Anhui Medical University, Hefei, China AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States Gastroenterology, AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States Mercy Internal Medicine Service, Trinity Health of New England, Springfield, MA, United States Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States University of Maryland Medical Center Midtown Campus, Baltimore, MD, United States College of Medicine, The University of Arizona, Tucson, AZ, United States 0Banner-University Medical Center South, Tucson, AZ, United States 1Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia 2Department of Radiation Oncology, Mayo Clinic, Rochester, MN, United States 3Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China)

出处: Frontiers in Oncology 2022 Vol.12

关键词: liver cancer;lysyl oxidase;bioinformatic analysis;receiver operating curve;nomogram;prognostic value

摘要: BackgroundLiver cancer (LC) is well known for its prevalence as well as its poor prognosis. The aberrant expression of lysyl oxidase (LOX) family is a ...

作者: Yafang Wang  1, Yang Liu  1, Shu Liu  1, Xiaomeng Li  1, Xinxin Liu  1   2, Ming Jiao  3, Yuqin Yang  3, Xueting Luo  1   2, Fenghua Wang  1   2   4   5   6, Xiaoling Wan  1   2, Xiaodong Sun  1   2   4   5   6 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China200080. 2 Shanghai Key Laboratory of Ocular Fundus Diseases, 100 Haining Road, Shanghai, China200080. 3 Laboratory Animal Center, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, China201620. 4 Shanghai Engineering Center for Visual Science and Photomedicine, 100 Haining Road, Shanghai, China200080. 5 National Clinical Research Center for Eye Diseases, 100 Haining Road, Shanghai, China200080. 6 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 100 Haining Road, Shanghai, China200080.)

出处: Disease models & mechanisms 2022 Vol.15 No.3 Pdmm049222

关键词: Cyp4v3;Bietti crystalline dystrophy;Lipid accumulation;Mouse model;Retinal degeneration.

摘要: Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and deve ...

作者: Mengmeng Jiang  1, Hai Xie  2, Chaoyang Zhang  3   4, Tianqin Wang  1, Haibin Tian  2, Lixia Lu  2, Jing-Ying Xu  2, Guo-Tong Xu  2, Lin Liu  1, Jingfa Zhang  3   4 (Affiliations 1 Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.)

出处: Journal of cellular and molecular medicine 2022

关键词: diabetic retinopathy;fractalkine;microglia;neuroinflammation.

摘要: The concept of diabetic retinopathy (DR) has been extended from microvascular disease to neurovascular disease in which microglia activation plays a r ...

作者: Yumeng Zhang  1, Zhenzhen Zhao  1, Xiaohuan Zhao  1, Hai Xie  2, Chaoyang Zhang  1, Xiaodong Sun  3, Jingfa Zhang  4 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. 2 Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: xdsun@sjtu.edu.cn. 4 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: jingfa.zhang@shgh.cn.)

出处: Free radical biology & medicine 2022 Vol.181 P14-28

关键词: HMGB2;Oxidative stress;Photoreceptor;Pyroptosis;Retinal degeneration.

摘要: In the pathogenesis of retinal degenerative diseases, oxidative stress is a key driver leading to photoreceptor death and eventually vision loss. Curr ...

作者: Yanrui Jin1,2;Jinlei Liu1,2;Yunqing Liu1,2;Chengjin Qin1,2;Zhiyuan Li1,2;Dengyu Xiao1,2;Liqun Zhao3;Chengliang Liu1,2 (1 School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China 2 MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China 3 Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, China)

出处: IEEE Transactions on Instrumentation and Measurement 2022 Vol.71 P1-11

关键词: Electrocardiography;Feature extraction;Rhythm;Convolutional neural networks;Deep learning;Diseases;Convolution

摘要: Arrhythmia accounts for more than 80% of sudden cardiac death, and its incidence rate has increased rapidly recently. Nowadays, many studies have appl ...

作者: Yu Tang1;Yunke Bi2;Hao Wei1;Zhongyu Hou1;Zi Wang1CA1 (1 National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai 200240, China; 2 Department of Neurosurgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201620, China)

出处: Sensors and Actuators B: Chemical 2022 Vol.353 P131127

关键词: Hydrogen peroxide;Electrochemical sensor;Porous silicon;Metal-assisted chemical etching;Hierarchical structure

摘要: Herein we would like to introduce a general method for improving the dynamic range for electrochemical sensing devices based on 3D porous electrodes b ...

作者: Ying Cao #  1, Ye Tian #  2   3, Heng Zhang  2, Guang-Heng Luo  2, Zhao-Lin Sun  2, Shu-Jie Xia  4 (Affiliations 1 Guizhou University School of Medicine, Guiyang, 550025, Guizhou, China. 2 Department of Urology, Guizhou Provincial People\'s Hospital, Guiyang, 550002, Guizhou, China. 3 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. 4 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. xsj4017@163.com.)

出处: International urology and nephrology 2022 Vol.54 No.3 P499-508

关键词: LUTS;Prostate fibrosis;Sex hormone;TGF-β/Smad signaling pathway.

摘要: Objective: The present study aimed to investigate the effects of an imbalance in the estrogen/androgen ratio on prostate fibrosis. Methods: Different ...

作者: Kaiyuan Liu  1, Yuxin Liao  1, Dong Yang  1, Tianyang Xu  1, Qiuming Gao  1, Wenwei Jiang  1, Lin Fan  1, Pengfei Zan  2, Guodong Li  1 (Affiliations 1 Department of Orthopedics, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Orthopedics, Shanghai First People\'s Hospital, Jiaotong University School of Medicine, Shanghai, China.)

出处: Frontiers in surgery 2022 Vol.9 P692072

关键词: MIS-TKA;clinical effectiveness;gap balance;patellar position;soft tissue balance.

摘要: Background: We hypothesized that subluxating patellar during minimally invasive total knee arthroplasty (MIS-TKA) would affect intraoperative soft tis ...

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