作者： Fang, XK (Fang, Xinkui)^1,2;Zhang, SK (Zhang, Shikuan)³;Sun, XD (Sun, Xiaodong)⁴;Li, JJ (Li, Jinjin)¹;Sun, T (Sun, Tao)^1,2 （1 School of Agriculture and Biology, Shanghai JiaoTong University, 800 Dongchuan Rd., Shanghai 200240, China 2 Shanghai Municipal Veterinary Key laboratory, 800 Dongchuan Rd., Shanghai 200240, China 3 College of Life Science and Food Engineering, Nanchang University, 235 Nanjing E. Road, Nanchang, Jiangxi 330047, China 4 Shanghai First People\'s Hospital, Shanghai Jiao Tong University, Shanghai 201620, China）

出处： Vaccine 2012 Vol.30 No.7 P1313-1321

关键词： Glycoprotein;Matrix protein;Vaccine vector;Vesicular stomatitis virus

摘要： Vesicular stomatitis virus (VSV) is a promising vector for vaccine and oncolysis, but it can also produce acute diseases in cattle, horses, and swine ...

作者： （a Life Sciences Institute, University of Michigan, Ann Arbor, MI, United States; b Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, United States; c Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, United States; d Laboratory of Structural and Functional Biology, Federal University of So Carlos (UFSCar), Campus Sorocaba, So Paulo State, Brazil; e Department of Biochemistry and Food Science, Hebrew University, Rehovot, Israel; f Oncology Research Unit, Pfizer Worldwide Research and Development, Pearl River, NY, United States; g MRC Mammalian Genetics Unit, Harwell, United Kingdom; h Research Institute, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; i Division of Geriatrics, Department of Clinical and Experimental Medicine, Linkping University, Linkping, Sweden; j Department of STEMBIO (Cell Biology), University of Palermo, Palermo, Italy; k Cell Death Research and Therapy Unit, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; l Department of Medicine, Mount Sinai School of Medicine, New York University, New York, NY, United States; m Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, South Korea; n Laboratoire Epigénétique et Destin Cellulaire, Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot Sorbonne Paris Cité, Paris, France; o Department of Biology, York University, Toronto, ON, Canada; p Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; q Department of Biological Sciences, Faculty of Science, University of Jordan, Amman, Jordan; r Department of Molecular Biology, Max Planck Institute for Infection Biology, Berlin, Germany; s Department of Immunology, Institut Pasteur, INSERM U818, Paris, France; t Department of Neurology, University of Michigan, Ann Arbor, MI, United States; u Geriatrics Research, Education, and Clinical Center, VAAAHS, Ann Arbor, MI, United States; v Oxford Parkinson\'s Disease Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; w Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Brescia, Italy; x Department of Immunology and Microbial Science, Scripps Research Institute, San Diego, CA, United States; y Department of Cancer Biology, Cleveland Clinic, Cleveland, OH, United States; z Infectomic and Molecular Pathogenesis Departament, Centro de Investigacion Y de Estudios Avanzados del Instituto Politecnico Nacional (CINVESTAV-IPN), México City, Mexico; aa Department of Preventive Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan; ab Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States; ac Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States; ad Department of Microbial Infection and Immunity, Center for Microbial Interface Biology, Ohio State University, Columbus, OH, United States; ae Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, United States; af INSERM UMR1037, University Paul Sabatier, Toulouse, France; ag University Paul Sabatier, Toulouse, France; ah Department of Biomedical Science, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA, United States; ai Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, CA, United States; aj Griffith Health Institute and School of Pharmacy, Griffith University, Gold Coast, QLD, Australia; ak Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan; al Departamento de Farmacologia, Facultad de Medicina, Universitat de Valencia, Valencia, Spain; am Ultrastructural Methods for Innovative Cancer Therapies Unit, Technology and Health Department, Italian National Institute of Health, Rome, Italy; an Department of Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, FL, United States; ao Division of Nephrology, Department of Internal Medicine, Juntendo University, Tokyo, Japan; ap Department of Chemical Toxicology, Norwegian Institute of Public Health, Oslo, Norway; aq Graduate School of Biostudies, Kyoto University, Kyoto, Japan; ar Department of Neurology, USC Neuromuscular Center, University of Southern California Keck School of Medicine, Los Angeles, CA, United States; as Department of Pathology, Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States; at INSERM U1065, Centre Mediterraneen de Medecine Moleculaire (C3M), University of Nice Sophia Antipolis, Nice, France; au University of Nice Sophia Antipolis, Nice, France; av Collaborative Open Research Center, Research Institute for Science and Technology, Kogakuin University, Tokyo, Japan; aw Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, United States; ax Biotechnology Research and Training Center, William C. Friday Laboratory, University of North Carolina Pembroke, Pembroke, NC, United States; ay Department of Nephrology, State Key Laboratory of Kidney Diseases, Chinese PLA General Hospital, Beijing, China; az Cytologie et Cytopathologie Neuronales, INCI-CNRS UPR 3212, Université de Strasbourg, Strasbourg, France; ba Division of Hematology, Ohio State University, Columbus, OH, United States; bb Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, United States; bc Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy; bd Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; be Jan and Dan Duncan Neurological Research Institute, Baylor College of Medicine, Houston, TX, United States; bf Department of Biological Sciences, University of Toledo, Toledo, OH, United States; bg MRC Toxicology Unit, University of Leicester, Lancaster Road, Leicester, United Kingdom; bh Semmelweis University, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Budapest, Hungary; bi Department of Genetics, Development and Cell Biology, Plant Sciences Institute, Iowa State University, Ames, IA, United States; bj Department of Experimental Therapeutics, MD Anderson Cancer Center, Houston, TX, United States; bk Catholic University of Louvain, Institute of Life Sciences, UCL/ISV, Louvain-la-Neuve, Belgium; bl Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; bm 35 INSERM UMR-S984, Université Paris Sud, Chatenay-Malabry, France; bn INRA UMR 1019, CRNH, Université d\'Auvergne, Clermont-Ferrand, France; bo College of Nanoscale Science and Engineering, University at Albany, SUNY, Albany, NY, United States; bp Institute for Pathobiochemistry, University Medical Center, Johannes Gutenberg-University, Mainz, Germany; bq Institute of Biochemistry II, Medical School Goethe University, Frankfurt, Germany; br Laboratoire de Biochimie Médicale, Rouen University Hospital and NeoVasc EA 4309, University of Rouen, Rouen, France; bs Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA, United States; bt Westmead Millennium Institute, University of Sydney, Westmead Institute for Cancer Research, Westmead, NSW, Australia; bu Vaccine Manufacturing Sciences and Commercialization, Merck Manufacturing Division, West Point, PA, United States; bv Department of Health Sciences, Magna Graecia University, Catanzaro, Italy; bw INRA, UMR866 Dynamique Musculaire et Métabolisme, Université Montpellier 1, Montpellier, France; bx Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy; by UMR5235, CNRS, Université de Montpellier 2, Montpellier, France; bz Department of Biochemistry, Comenius University, Bratislava, Slovakia; ca Basic Medical Sciences, Western University of Health Sciences, Pomona, CA, United States; cb Centre d\'études d\'Agents Pathogènes et Biotechnologies Pour la Santé, CNRS UM1, UM2, Montpellier, France; cc Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, United States; cd Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, United States; ce Department of Biomedical Sciences, University of Padova, Padova, Italy; cf Department of Medicine, University of Chicago, Chicago, IL, United States; cg Department of Oncology, University Children\'s Hospital, University of Zurich, Zurich, Switzerland; ch Department of Biological Sciences and Cellular and Molecular Therapy Center, Universidade Federal de So Paulo, So Paulo, Brazil; ci Department of Veterinary Medicine, University of Maryland, College Park, MD, United States; cj Department of Cell Proliferation and Development, Centro de Investigaciones Biológicas, CIB-CSIC, Madrid, Spain; ck Université de Franche-Comté, Laboratoire de Biochimie, IFR133, Besanon, France; cl Department of Plant Biology and Forest Genetics, Uppsala BioCentre, Swedish University of Agricultural Sciences, Uppsala, Sweden; cm Systems Biology of Cell Death Mechanisms, German Cancer Research Center (DKFZ), University of Heidelberg, Heidelberg, Germany; cn Dipartment Scienze Mediche e Biologiche, Università degli Studi di Udine, Udine, Italy; co Centre for Cancer Biomedicine, University of Oslo, Oslo University Hospital, Oslo, Norway; cp Department of Cell and Developmental Biology, UNC School of Medicine, Chapel Hill, NC, United States; cq Research Unit for Tropical Diseases, De Duve Institute, Université Catholique de Louvain, Brussels, Belgium; cr Department of Cell and Regenerative Biology, Paul Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; cs University of Nice-Sophia Antipolis, Institute of Research on Cancer and Ageing, INSERM U1081, Nice, France; ct Virginia Commonwealth University, Departments of Pharmacology and Toxicology, Goodwin Research Laboratories, Richmond, VA, United States; cu Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY, United States; cv Department of Microbial Pathogenesis, Genentech, Inc., South San Francisco, CA, United States; cw Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada; cx Division of Pharmacology, Faculty of Health Sciences, Linkping University, Linkping, Sweden; cy Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada; cz Department of Genetics, University of North Carolina, Chapel Hill, NC, United States; da Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; db Hertie-Institute for Clinical Brain Research, University of Tuebingen, German Center for Neurodegenerative Diseases, Tuebingen, Germany; dc Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria; dd Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Ohio State University, Columbus, OH, United States; de Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland; df Laboratory of Genetics and Molecular Hematology, University of So Paulo School of Medicine, So Paulo, Brazil; dg Skirball Institute of Biomolecular Medicine, Department of Microbiology, New York University School of Medicine, New York, NY, United States; dh Department of Metabolism and Diabetes, Institute of Clinical and Experimental Medicine, Prague, Czech Republic; di Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States; dj Vanderbilt Eye Institute, Vanderbilt University, Nashville, TN, United States; dk Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, United States; dl Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States; dm Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), Madrid, Spain; dn Team Mitochondries, Stress et Morts Cellulaires, Institut de Biochimie et de Génétique Cellulaires (IBGC), Université Bordeaux-Ségalen, Bordeaux, France; do Royal Veterinary College, University of London, Consortium for Mitochondrial Research, London, United Kingdom; dp EBRI-Rita Levi Montalcini Foundation, Rome, Italy; dq Institute of Parasitology and Biomedicine Lopez-Neyra-CSIC, Department of Cell Biology and Immunology, Granada, Spain; dr Department of Biochemistry, University of Rome Tor Vergata, Rome, Italy; ds Department of Pediatrics, Xiangya Hospital, Central South University, China; dt Department of Plant, Soil, and Entomological Sciences, University of Idaho, Moscow, ID, United States; du Institute of Food Research, Norwich School of Medicine, University of East Anglia, Norwich Research Park, Norwich, United Kingdom; dv Department of Mucosal Immunology, Norwich School of Medicine, University of East Anglia, Norwich Research Park, Norwich, United Kingdom; dw Faculty of Medicine, Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal; dx Department of Medicine, Division of Hematology/Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; dy Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, United States; dz Muscle Biology Unit, Departement of Experimental Medical Science, Lund University, Lund, Sweden; ea Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; eb Department of Medical Biosciences, University of Modena and Reggio Emilia, Italy; ec Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ed Department of Human Pathology, University of Messina, Messina, Italy; ee Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy; ef Institute of Neuroscience, Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Barcelona, Spain; eg Department of Health Sciences, Università del Piemonte Orientale A. Avogadro, Novara, Italy; eh Department of Cell Biology, Institute of Biomembranes, University Medical Centre Utrecht, Utrecht, Netherlands; ei Department of Biochemistry and Cell Biology, Institute of Biomembranes, Utrecht University, Utrecht, Netherlands; ej IRCCS Santa Lucia Foundation, Rome, Italy; ek Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, Rome, Italy; el Laboratory of Intracellular Parasites, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States; em Division of Radiation Biology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany; en Department of Pharmacology, Cardiovascular Research Institute, Chonbuk University, Chonbuk, South Korea; eo Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; ep Division of Biology, California Institute of Technology, Pasadena, CA, United States; eq Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom; er Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; es Department of Chemistry, University of Hong Kong, Hong Kong, Hong Kong; et Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan; eu Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan; ev Key Laboratory of Cell Differentiation and Apoptosis of Chinese, Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China; ew Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United States; ex State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; ey College of Life Sciences, Nankai University, Tianjin, China; ez Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; fa MOE Key Laboratory of Laser Life Science, Institute of Laser Life Science, South China Normal University, Guangzhou, China; fb Children\'s Hospital, Zhejiang University School of Medicine, Hangzhou, China; fc Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi\'an, China; fd School of Life Sciences, Tsinghua University, Beijing, China; fe Department of Immunology, Peking University, Center for Human Disease Genomics, Beijing, China; ff Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, United States; fg Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan; fh Department of Botany and Plant Pathology, Purdue University, West Lafayette, IN, United States; fi Department of Biochemistry and Molecular Biology, University of Louisville, Louisville, KY, United States; fj School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, Hong Kong; fk Department of Pharmacology, Pennsylvania State University College of Medicine, Penn State Hershey Cancer Institute, Hershey, PA, United States; fl Penn State Hershey Cancer Institute, Hershey, PA, United States; fm Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; fn Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea; fo Department of Microbiology, University of Pennsylvania, Philadelphia, PA, United States; fp Faculty of Health Sciences and Medicine, Bond University, QLD, Australia; fq Department of Biochemistry, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong; fr INSERM U1053, Université Bordeaux Segalen, Bordeaux, France; fs Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA, United States; ft Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan; fu Department of Pharmacology, Emory University School of Medicine, Atlanta, GA, United States; fv Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; fw School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong; fx Graduate School of East-West Medical Science, Kyung Hee University, Yongin, South Korea; fy Division of Pulmonary and Critical Care Medicine, Brigham and Women\'s Hospital, Harvard Medical School, Boston, MA, United States; fz Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; ga Institute for Medical Sciences, Ajou University School of Medicine, Suwon, South Korea; gb Department of Medicine, Brigham and Women\'s Hospital, Harvard Medical School, Boston, MA, United States; gc INSERM U753 PR1, Institut Gustave Roussy, Villejuif, France; gd Department of Environmental Health, University of Cincinnati, Cincinnati, OH, United States; ge Department of Pharmacology, Tartu University, Tartu, Estonia; gf Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; gg Center for Neuroscience, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; gh Immunology Research Center, National Health Research Institutes, Miaoli County, Taiwan; gi Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan; gj School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea; gk Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea; gl School of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong; gm Department of Structures, Function and Biological Technologies, University of Naples Federico II, Naples, Italy; gn IRCCS San Raffaele, Rome, Italy; go Physiological Laboratory, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom; gp Safar Center for Resuscitation Research, Pittsburgh, PA, United States; gq Département de Biologie Cellulaire et de Morphologie, Université de Lausanne, Lausanne, Switzerland; gr Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington DC, United States; gs INSERM U984, University of Paris-South, Paris, France; gt Department of Molecular Biology, Princeton University, Princeton, NJ, United States; gu Laboratorio de Biologia Celular Y Molecular, Instituto de Histologia Y Embriologia, Universidad Nacional de Cuyo-CONICET, Mendoza, Argentina; gv Department of Genetics and Microbiology, University of Pavia, Pavia, Italy; gw Pharmacology, Faculty of Pharmacy, Università del Piemonte Orientale A. Avogadro, Novara, Italy; gx Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institutes of Health, Bethesda, MD, United States; gy Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, MD, United States; gz Departamento Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile; ha Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, France; hb INSERM, INRA, USC2020, Paris, France; hc Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy; hd Larry Hillblom Islet Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, United States; he Departamento de Morfología Y Biología Celular, Universidad de Oviedo, Oviedo, Spain; hf Departamento de Biología Y Cs Ambientales, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile; hg Division of Applied Medicine, University of Aberdeen, Aberdeen, United Kingdom; hh Keck Graduate Institute of Applied Sciences, Claremont, CA, United States; hi Instituto de Bioquimica Vegetal Y Fotosintesis (CSIC-Universidad de Sevilla), Sevilla, Spain; hj Department of Biochemistry, University of Johannesburg, Johannesburg, South Africa; hk Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, United States; hl Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, United States; hm Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, United States; hn Department of Surgery, University of Iowa, Iowa City, IA, United States; ho Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States; hp European Centre for Brain Research, Santa Lucia Foundation, University Campus-Biomedico, Rome, Italy; hq Microbes, Intestin, Inflammation and Susceptibility of the Host, USC-INRA 2018, Clermont-Ferrand, France; hr UMR 1071 INSERM, Université Auvergne, Clermont-Ferrand, France; hs Department of Pediatrics, Federico II University, Naples, Italy; ht Department of Human Biology, University of Cape Town, Cape Town, South Africa; hu Division of Molecular Pathology, Cancer Therapeutics and Clinical Studies, Institute of Cancer Research and Royal Marsden Hosptial, Sutton, Surrey, United Kingdom; hv Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome, Italy; hw Department of Neuro- Oncology, MD Anderson Cancer Center, University of Texas, Houston, TX, United States; hx Virology Division, Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands; hy Department of Pathology and Animal Health, University of Naples Federico II, Naples, Italy; hz Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden; ia Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy; ib Department of Pathology, University of California, San Francisco, CA, United States; ic Department of Biochemistry, Tufts University School of Medicine, Boston, MA, United States; id CNRS UMR 5293, Institut des Maladies Neurodégénératives, UniversitéBordeaux Segalen, Bordeaux, France; ie Department of Physiology, University of Melbourne, Parkville, VIC, Australia; if Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, Trieste, Italy; ig Fungal Patho-Biology Group, Temasek Life Sciences Laboratory, National University of Singapore, Singapore; ih Freiburg Institute for Advanced Studies (FRIAS), School of Life Sciences (LifeNet), Freiburg, Germany; ii Department of Neurosurgery, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; ij Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia; ik School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA, Australia; il Department of Molecular Genetics and Microbiology, University of New Mexico Health Science Center, Albuquerque, NM, United States; im Department of Biochemistry and Molecular Biology, Louisiana State University-Health Sciences Center-School of Medicine, New Orleans, LA, United States; in Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, VIC, Australia; io ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton Campus, Melbourne, VIC, Australia; ip Unit of Allergy and Immunotoxicology, Ageing Research Center (Ce.S.I.), Università G. d\'Annunzio Foundation, Chieti, Italy; iq Taub Institute for Alzheimer\'s Disease Research, Columbia University Medical Center, New York, NY, United States; ir Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, United States; is Institute of Cell Biology and Neurobiology, EMMA-CNR, Campus A. Buzzati Traverso, Rome, Italy; it Department of Pharmacological and Toxicological Chemistry, University of Chile, Santiago, Chile; iu Department of Biochemistry and Molecular Biology, School of Medicine, University of Alcalá, Madrid, Spain; iv Sanford-Burnham Medical Research Institute, San Diego, CA, United States; iw Departamento de Biología Molecular, Centro de Biologia Molecular Severo Ochoa (UAM-CSIC), Universidad Autonoma de Madrid, Madrid, Spain; ix Molecular Signaling, Frankfurt Institute for Molecular Life Sciences, Frankfurt am Main, Germany; iy Department of Plant Biology, College of Biological Sciences, University of California, Davis, CA, United States; iz Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, United States; ja Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States; jb Department of Pharmacology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States; jc Department of Pathology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States; jd Comprehensive Cancer Center, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, United States; je University Hospitals of Cleveland, Cleveland, OH, United States; jf Center for Cardiovascular Research, Washington University School of Medicine, Saint Louis, MO, United States; jg Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, United States; jh INSERM U916 VINCO, Université Bordeaux, Bordeaux, France; ji CNRS UMR 8126, Université Paris-Sud 11, Institut Gustave Roussy, Villejuif, France; jj Department of Cellular Biology and Anatomy, Georgia Health Sciences University, Charlie Norwood VA Medical Center, Augusta, GA, United States; jk Institute of Complex Systems, ICS-6, Research Centre Jülich, Jülich, Germany; jl Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, United States; jm General and Molecular Pathophysiology Department, Bogomoletz Institute of Physiology, Kiev, Ukraine; jn Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, United States; jo Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA, United States; jp Department of Human Virology, INSERM U758, Ecole Normale Supèrieure de Lyon, Lyon, France; jq Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Techology and Science, Wuhan, Hubei, China; jr Division of Hematology, Central Laboratory of Hematology, Lausanne University Hospital, Lausanne, Switzerland; js Centre de Recherche des Cordeliers, INSERM, Paris, France; jt Université Pierre et Marie Curie, Paris, France; ju Department of Biochemistry, University of Tuebingen, Tuebingen, Germany; jv Division of Renal Diseases and Hypertension, University of Colorado at Denver, Aurora, CO, United States; jw Department of Developmental and Cell Biology, University of California, Irvine, CA, United States; jx Department of Biología Celular, Inmunología Y Neurociencias, Facultad de Medicina, Universidad de Barcelona-IDIBAPS, Barcelona, Spain; jy Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany; jz Department of Medicine, Baylor College of Medicine, Houston, TX, United States; ka Department of Melanoma Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, United States; kb Department of Medicine (Hematology/Oncology), Penn State College of Medicine, Penn State Hershey Medical Center, Hershey PA, United States; kc Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel; kd European Institute of Oncology, Department of Biomolecular Sciences and Biotechnologies, University of Milan, Milan, Italy; ke Buck Institute for Research on Aging, Novato, CA, United States; kf Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; kg Department of Physiological Sciences, University of Stellenbosch, Stellenbosch, South Africa; kh Department of Pharmacology, B. Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; ki Latvian Biomedical Research and Study Centre, Riga, Latvia; kj Department of Biosciences, University of Helsinki, Helsinki, Finland; kk Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA, United States; kl Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, United States; km Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China; kn Departments of Neurology, Pediatrics, Neurological Surgery and Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, United States; ko Center for Biomedical Engineering and Technology (BioMET), University of Maryland, Baltimore, Baltimore, MD, United States; kp Department of Physiology, University of Maryland, Baltimore, Baltimore, MD, United States; kq Guangzhou University of Chinese Medicine, Guangzhou, China; kr MRC Centre for Developmental Neurobiology, King\'s College London, United Kingdom; ks Cell Death and Metabolism, Danish Cancer Society Research Center, Copenhagen, Denmark; kt Section of Molecular Biology, Division of Biological Sciences, University of California;San Diego, San Diego, CA, United States; ku INSERM U851, Université de Lyon, Université Lyon 1, Lyon, France; kv Department of Cellular Biology, University of Georgia, Athens, GA, United States; kw Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; kx Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, United States; ky Guangdong Provincial Key Lab. of Biotechnology for Plant Development, School of Life Sciences, South China Normal University, Guangzhou, China; kz Department of Obstetrics and Gynecology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University, Shanghai, China; la Departments of Biochemistry and Molecular Biology, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary; lb Cell and Molecular Biology Joint Doctoral Program, Department of Biology, San Diego State University, San Diego, CA, United States; lc Department of Biological Sciences, Hunter College, City University of New York, New York, NY, United States; ld National Institute for Infectious Diseases IRCCS L. Spallanzani, Rome, Italy; le Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, United States; lf Gladstone Institutes, Taube-Koret Center for Huntington\'s Disease, University of California, San Francisco, CA, United States; lg Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States; lh Bioscience Center, San Diego State University, San Diego, CA, United States; li Departments of Medicine and Cell Biology, Marc and Ruti Bell Program in Vascular Biology, New York University School of Medicine, New York, NY, United States; lj Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; lk Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, United States; ll Institute for Behavioral Genetics, University of Colorado, Boulder, CO, United States; lm McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; ln Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy; lo University Hospital Heidelberg, Department of Surgery/Research Lab., Heidelberg, Germany; lp Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States; lq Redox Biology Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, United States; lr Biotech. Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark; ls Department of Molecular and Cellular Medicine, University of Leuven, Leuven, Belgium; lt Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Departamento Bioquímica Y Biología Molecular Y Genética;E.U. Enfermería, Universidad de Extremadura, Cáceres, Spain; lu Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Kagoshima, Japan; lv Laboratory of Emerging Infectious Diseases, Department of Frontier Veterinary Medicine, Kagoshima University, Kagoshima, Japan; lw Department of Pediatrics, Jichi Medical Universtiy, Tochigi, Japan; lx Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Miyagi, Japan; ly Institute of Physiological Chemistry, Hannover Medical School, Hannover, Germany; lz Laboratory of Cell Physiology, University of Louvain, Brussels, Belgium; ma Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland; mb UMR CNRS 7622, Biologie du Développement, Université Pierre et Marie Curie, Paris, France; mc Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India; md Laboratory of Genetics, University of Wisconsin, Madison, WI, United States; me MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee, United Kingdom; mf Department of Neurology, University of Massachusetts Medical School, Worcester, MA, United States; mg CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China; mh Oncology and Pharmacology, UT Southwestern Medical Center, Dallas, TX, United States; mi Centro Estudios Moleculares de la Celula, Facultad Ciencias Quimicas Y Farmaceuticas and Facultad Medicina, Universidad de Chile, Santiago, Chile; mj Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TX, United States; mk Department of Biochemistry, School of Medicine, Boston University, Boston, MA, United States; ml Laboratory of Dermatology, Department of Oncology, University of Leuven, Leuven, Belgium; mm Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States; mn Centre d\'Immunologie de Marseille-Luminy, Aix-Marseille Univ. UM2, CNRS UMR7280, Marseille, France; mo Randall Division for Cell and Molecular Biophysics, Cardiovascular Division, Kings College London, London, United Kingdom; mp Department of Biology, University of Kentucky, Lexington, KY, United States; mq Department of Clinical Neurosciences, Institute of Neurology, University College London, London, United Kingdom; mr Department of Cell Biology, Harvard Medical School, Boston, MA, United States; ms Department of Cellular Molecular Medicine, University of Ottawa, Ottawa, ON, Canada; mt Department of Pathology, University of Michigan, Ann Arbor, MI, United States; mu Department of Physiology, Manitoba Institute of Child Health, University of Manitoba, MB, Canada; mv Department of Medicine, University of California San Diego School of Medicine, San Diego, CA, United States; mw Department of Therapeutic Research and Medicine Evaluation, Istituto Superiore di Sanita, Rome, Italy; mx Department of Pathology, Democritus University of Thrace, University General Hospital of Alexandroupolis, Alexandroupolis, Greece; my Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, MB, Canada; mz Department of Neurology, Columbia University Medical Center, New York, NY, United States; na School of Health and Medicine, Lancaster University, Lancaster, United Kingdom; nb Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY, United States; nc Department of Immunology, Medical University of Warsaw, Warsaw, Poland; nd Renal Research Institute, New York Medical College, Valhalla, NY, United States; ne Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, United States; nf Biology Department, Faculty of Science, Ege University, Bornova, Izmir, Turkey; ng Institut de Recherche en Cancérologie de Montpellier, INSERM U896, Université Montpellier1, Montpellier, France; nh Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina; ni Instituto de Ciencias de la Vid Y del Vino, CSIC-UR-CAR, Logroo, Spain; nj Department of Developmental Genetics and Gene Control, University of Nottingham, Queen\'s Medical Centre, Nottingham, United Kingdom; nk Henry M. Jackson Foundation for the Advancement of Military Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States; nl Genome Sciences Center, BC Cancer Agency, Vancouver, BC, Canada; nm Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States; nn Biological Sciences and Bioengineering Program, Sabanci University, Orhanli;-Tuzla, Istanbul, Turkey; no Department of Neurobiology and Behavior, University of California, Irvine, CA, United States; np Agricultural Institute of Slovenia, Ljubljana, Slovenia; nq University of Strasbourg, Immunologie et Chimie Thérapeutiques, CNRS, Strasbourg, France; nr Department of Pediatrics, Children\'s Hospital, University of Iowa, Iowa City, IA, United States; ns Signaling Networks Program, Comprehensive Cancer Center, Medical University Vienna and Ludwig Boltzmann Cluster Oncology, Vienna, Austria; nt Department of Pharmacology, Moores Cancer Center, University of California San Diego, San Diego, CA, United States; nu AstraZeneca, Cancer and Infection Research Area, Cheshire, United Kingdom; nv Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, United States; nw Department and Laboratory of Intensive Care Medicine, Katholieke Universiteit Leuven, Leuven, Belgium; nx Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, United States; ny Department of Internal Medicine, Manitoba Institute of Child Health, University of Manitoba, Winnipeg, MB, Canada; nz Department of Microbiology, Montana State University, Bozeman, MT, United States; oa Department of Genetics, Osaka University Graduate School of Medicine, Osaka, Japan; ob Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China; oc Discovery and ADMET-TOX Systems, Life Technologies, Madison, WI, United States; od Department of Oral and Craniofacial Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, United States; oe Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; of Department of Cardiology, Angiology and Pulmology, University of Heidelberg, Heidelberg, Germany; og Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom; oh Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland; oi Center for Plant Science Innovation, University of Nebraska-Lincoln, Lincoln, NE, United States; oj Division of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; ok VA Boston Healthcare System, Boston, MA, United States; ol Divison of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Osaka, Japan; om Molecular Oncology, Moffitt Cancer Center, Tampa, FL, United States; on Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, United States; oo Department of Immunology, Duke University Medical Center, Durham, NC, United States; op Department of Nephrology, CRCHUM, Montréal, QC, Canada; oq Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, United States; or College of Medical, Veterinary and Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom; os Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; ot Department of Molecular Genetics, Ohio State University, Columbus, OH, United States; ou Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; ov Department of Molecular Biology, Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain; ow Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, United States; ox RIKEN, Plant Science Center, Tsurumi-ku, Yokohama, Japan; oy Cellular Senescence Group A210, German Cancer Research Center, DKFZ-ZMBH Alliance, Heidelberg, Germany; oz Molecular Cell Biology, Institute for Cell Biology, University Bonn, Bonn, Germany; pa GCP Center, Cancer Center of Sun Yat-sen University, Guangzhou, China; pb School of Kinesiology and Health Science, York University, Toronto, ON, Canada; pc Harvard University, School of Public Health, Boston, MA, United States; pd Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands; pe Department of Molecular Biomedicine, LEO Pharma A/S, Ballerup, Denmark; pf Neurology and Anesthesiology, Shock Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, United States; pg Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM, United States; ph Laboratory of Cancer Immunobiology, Earle A. Chiles Research Institute, Providence Portland Medical Center, Portland, OR, United States; pi Department of Neurosurgery, University of Michigan, Ann Arbor, MI, United States; pj State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; pk Department of Medicine, Mayo Clinic and Mayo Cancer Center, Rochester, MN, United States; pl Department of Life Science and Institute of Zoology, National Taiwan University, Taipei, Taiwan; pm Renal Division, University Hospital Freiburg, Albert-Ludwigs-University, Freiburg, Germany; pn School of Biological Sciences and Research Center for Functional Cellulomics, Seoul National University, Seoul, South Korea; po Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Taipei, Taipei, Taiwan; pp Department of Experimental Cancer Research, University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom; pq Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, South Korea; pr Department of Biochemistry, University of Washington, Seattle, WA, United States; ps Critical Care Department, McGill University, Montreal, QC, Canada; pt School of Biological and Biomedical Sciences, University of Durham, Durham, United Kingdom; pu Institute for Innovative Cancer Research, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; pv Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States; pw Department of Medicine II, Endocrinology and Hypertension, Tokyo Women\'s Medical University, Tokyo, Japan; px Department of Molecular and Integrative Physiology, Division of Nephrology, University of Michigan Medical School, Ann Arbor, MI, United States; py Department of Oral Microbiology, Division of Oral Infections and Health Sciences, Asahi University School of Dentistry, Mizuho, Japan; pz INSERM U624, University of Méditerranée, Marseille, France; qa Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, Hong Kong; qb Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan; qc Department of Applied Plant Science, Graduate School of Agricultural Sciences, Tohoku University, Miyagi, Japan; qd Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya University, Nagoya, Japan; qe Department of Immunobiology, Yale University School of Medicine, New Haven, CT, United States; qf Division of General Thoracic Surgery, School of Medicine, Keio University, Tokyo, Japan; qg Centre for Biotechnology, University of Turku, Turku, Finland; qh Department of Neurology, University of Texas Medical Branch, Galveston, TX, United States; qi Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, United States; qj Laboratory of Experimental-Hemato-Oncology, Department of Oncology, Public Research Center for Health (CRP-Santé), Luxembourg City, Luxembourg; qk Department of Neurology, University Medical School, Goethe University, Frankfurt/Main, Germany; ql Department of Physiology, Seoul National University College of Medicine, Seoul, South Korea; qm Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, South Korea; qn Key Laboratory of Hepatosplenic Surgery, Department of General Surgery, Harbin Medical University, Harbin, China; qo Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX, United States; qp Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville TN, United States; qq Department of Nutrition Science, Purdue University, West Lafayette, IN, United States; qr Department of Cell Biology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States; qs State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; qt Departamento de Microbiología Y Genética, Universidad de Salamanca, Salamanca, Spain; qu Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, United States; qv Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; qw Biochemistry Department, Institute of Medical Biology, University of Troms, Troms, Norway; qx Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States; qy Cell Biology Program, Departments of Paediatrics and Physiology, University of Toronto, Toronto, ON, Canada; qz Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA, United States; ra Department of Physiology, University of Pretoria, Pretoria, South Africa; rb Department of Anatomy, Cell and Developmental Biology, Etvs Loránd University, Budapest, Hungary; rc University Institute of Pathology, CHUV, University of Lausanne, Lausanne, Switzerland; rd Functional Food Technology Research Group, Korea Food Research Institute, South Korea; re Department of Biological Science, Seoul National University, Seoul, South Korea; rf Department of Ophthalmology, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland; rg Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan; rh Department of Applied Biological Chemistry, Niigata University, Niigata, Japan; ri Department of Clinical and Experimental Medicine, Faculty of Health Science, Linkping University, Linkping, Sweden; rj Laboratory of Biological Diversity, National Institute for Basic Biology, Okazaki, Japan; rk Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; rl Gifu University Graduate School of Medicine, Division of Cardiology, Gifu, Japan; rm Howard Hughes Medical Institute, Brigham and Women\'s Hospital, Harvard Medical School, Boston, MA, United States; rn Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, Singapore; ro Department of Chemistry and Biology, Korea Science Academy of KAIST, Busan, South Korea; rp Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, United States; rq Department of Clinical Chemistry and Laboratory Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; rr Department of Immunology, St. Jude Children\'s Research Hospital, Memphis, TN, United States; rs Department of Orthopaedic Surgery, Tohoku University School of Medicine, Miyagi, Japan; rt Department of Internal Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ, United States; ru Central Arkansas Veterans Healthcare System, Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States; rv Division of Biochemistry, Institute for Chemical Research, Kyoto University, Kyoto, Japan; rw Department of Biochemistry and Molecular Biology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; rx B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institutes of Health, Bethesda, MD, United States; ry Department of Laboratory Medicine and Pathology, University of Minnesota Cancer Center, Minneapolis, MN, United States; rz Fraunhofer Group Extracorporeal Immune Modulation (EXIM), Division of Nephrology, Department of Internal Medicine, Rostock, Germany; sa Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, United States; sb Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, Menoufiya University, El-Sadat City, Egypt; sc Groningen Biomolecular Sciences and Biotechnology Institute (GBB), Kluyver Centre for Genomics of Industrial Fermentation, University of Groningen, Haren, Netherlands; sd Section of Cell and Developmental Biology, University of California, San Diego, San Diego, CA, United States; se Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan; sf Department of Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, JinJu, South Korea; sg Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, United States; sh Cell Dysfunction Research Center (CDRC), Department of Anatomy and Cell Biology, University of Ulsan College of Medicine, Seoul, South Korea; si Department of Brain Science, Daegu Gyeongbuk Institute of Science and Technology, Daegu, South Korea; sj Department of Dental Pharmacology, College of Dentistry, Wonkwang University, Chonbuk, South Korea; sk Department of Surgery, University of Florida, Gainesville, FL, United States; sl Fight Against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University College of Medicine, Seoul, South Korea; sm Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea; sn Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States; so Department of Biochemistry, University of Toronto, Toronto ON, Canada; sp Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, South Korea; sq Ilsong Institute of Life Science, College of Medicine, Hallym University, Chuncheon, South Korea; sr Department of Microbiology, College of Medicine, Hallym University, Chuncheon, South Korea; ss Department of Chemical Biochemical and Environmental Engineering, University of Maryland, Baltimore County, Baltimore, MD, United States; st Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel; su Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States; sv Tumour Cell Death Laboratory, Beatson Institute for Cancer Research, Glasgow, United Kingdom; sw Department of Radiation Oncology, Warren Alpert Medical School, Rhode Island Hospital, Providence, RI, United States; sx Merck Serono, Merck KGaA, Darmstadt, Germany; sy Department of Pharmacology and Therapeutics, Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Winnipeg, MB, Canada; sz Department of Biotechnology, University of Tokyo, Tokyo, Japan; ta Department of Molecular Miocrobiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan; tb Institute for Immunology, University of Munich, Munich, Germany; tc Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, United States; td Division of Molecular Neurology, University Hospital, Erlangen, Germany; te Department of Cell Biology, Centro de Investigación Príncipe Felipe, Valencia, Spain; tf Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in Southern China, Chinese University of Hong Kong, Hong Kong, Hong Kong; tg Department of Neurology, University Medicine Gttingen, Gttingen, Germany; th Department of Neurology, University of Ulsan College of Medicine, Seoul, South Korea; ti Department of Cell Biology and Neuroscience, Juntendo University School of Medicine, Tokyo, Japan; tj Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan; tk Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan; tl Biotechnology Research Division, National Fisheries Research and Development Institute (NFRDI), Busan, South Korea; tm Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong Science and Technology University, Wuhan, China; tn Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom; to Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; tp Department of Radiotherapy-Oncology, Democritus University of Thrace, Alexandroupolis, Greece; tq Max F. Perutz Laboratories, University of Vienna, Vienna, Austria; tr Massachusetts General Hospital, Harvard Medical School, Department of Neurology, Charlestown, MA, United States; ts Departments of Neuroscience and Cell Biology, University of Texas Southwesten Medical Center, Dallas, TX, United States; tt Centre de Génétique et de Physiologie Moléculaire et Cellulaire, CNRS-UMR5534, Université Lyon I, Villeurbanne, France; tu Department of Neurology, Brigham and Women\'s Hospital, Harvard Medical School, Boston, MA, United States; tv Faculty of Medicine, University of Paris Descartes, Paris, France; tw Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany; tx Signaling Program, Babraham Institute, Cambridge, United Kingdom; ty Division of Developmental Biology, Cincinnati Children\'s Hospital Research Foundation, Cincinnati, OH, United States; tz Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland; ua Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY, United States; ub Department of Basic Sciences, Commonwealth Medical College, Scranton, PA, United States; uc Department of Pathology, St. Jude Children\'s Research Hospital, Memphis, TN, United States; ud Department of Biochemistry and Molecular Medicine, University of California, Davis Cancer Center, Sacramento, CA, United States; ue Department of Biotechnology, Yonsei University, College of Life Science and Biotechnology, Seoul, South Korea; uf Departments of Pediatrics, Cellular and Molecular Medicine, and Neurosciences, Institute for Genomic Medicine, University of California, San Diego, San Diego, CA, United States; ug Rady Children\'s Hospital, San Diego, CA, United States; uh Center for Infection and Immunity of Lille, Institut Pasteur de Lille, University Lille Nord de France, Lille, France; ui Laval Universtity Cancer Research Center, QC, Canada; uj School of Biochemistry, University of Bristol, University Walk, Bristol, United Kingdom; uk Nuclear Organisation and Oncogenesis Unit, INSERM U993, Institut Pasteur, Paris, France; ul Department of Translational Medecine, CNRS UMR7104, Université de Strasbourg, Illkirch, France; um School of Biomedical Sciences, University of Nottingham, Queen\'s Medical Centre, Nottingham, United Kingdom; un Instituto de Biología Molecular Y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Salamanca, Salamanca, Spain; uo Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, Shanghai, China; up Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; uq Translational Cancer Therapeutics Laboratory, Cancer Research UK London Research Institute, London, United Kingdom; ur Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; us Department of Psychiatry, Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY, United States; ut Division of Life Sciences, University of Incheon, Incheon, South Korea; uu Department of Medicine, Samsung Medical Center, Seoul, South Korea; uv Department of Pathology, College of Medicine, Catholic University of Korea, Seoul, South Korea; uw Department of Aging and Geriatrics, Division of Biology of Aging, University of Florida, Gainesville, FL, United States; ux University of Rennes-1, IRSET, INSERM U1085, Rennes, France; uy Centre de Génétique Moléculaire, CNRS UPR3404, Université Paris Sud, Gif-sur-Yvette, France; uz Department of Biological Sciences, University of Arkansas, Fayetteville, AR, United States; va Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; vb Biomedical Sciences Institute, Shanghai Medical College, Fudan University, Shanghai, China; vc Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, United States; vd Universidad de Santiago de Compostela, Laboratorio de Parasitología, Instituto de Investigación Y Análisis Alimentarios, La Corua, Spain; ve Departments of Pharmaceutical and Biomedical Sciences and Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, United States; vf Department of Biochemistry and Molecular Biology, University of Paris 11, Inserm U1004, Villejuif, France; vg Department of Surgery and Cancer Biology, University of Chicago, Chicago, IL, United States; vh Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, TX, United States; vi Department of Radiation Oncology, Rush University Medical Center, Chicago, IL, United States; vj AgroParisTech, Institut Jean-Pierre Bourgin, Versailles, France; vk Department of Pharmacology, Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, Orangeburg, NY, United States; vl Department of Genetics, University of Wisconsin, Madison, WI, United States; vm Department of General Surgery, Central Hospital of Yongzhou City, Hunan, China; vn Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai, China; vo Department of Chemistry, Hanshan Normal University, Chaozhou, China; vp Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China; vq Department of Endocrinology, Harbin Medical University, Harbin, China; vr Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, United States; vs Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA, United States; vt Cardiovascular Health Research Center, University of South Dakota, University of South Dakota Sanford School of Medicine, Sioux Falls, SD, United States; vu Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan; vv Department of Molecular Pathololgy and Neuropathology, Medical University Lodz, Lodz, Poland; vw Department of Biomedical Science and Technology, Konkuk University, Seoul, South Korea; vx Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; vy Department of Biochemistry, College of Medicine, Chungnam National University, Daejeon, South Korea; vz Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; wa Biotechnology Institute, Zhejiang University, Hangzhou, China; wb Beijing NMR Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, China; wc Department of Cancer Signaling, Genentech, South San Francisco, CA, United States; wd Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, United States; we Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; wf Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD, United States; wg Department of Stem Cell Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, United States; wh Department of Ophthalmology, Duke University, Durham, NC, United States; wi Department of Neurology, Institute of Neuroscience, Soochow University, Suzhou, China; wj College of Life Science, Central China Normal University, Wuhan, China; wk Center for Cancer and StemCell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX, United States; wl Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, United States; wm Metabolism and Cancer Susceptibility Section, Basic Research Laboratory, Center for Cancer Research, Frederick, MD, United States; wn Division of Natural Science, College of Liberal Education, Shu-Te University, Taiwan; wo Department of Biology, Queens College and Graduate Center of CUNY, Flushing, NY, United States; wp Departamento de Bioquímica Y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain; wq University of Turin, Turin, Italy; wr Department of Immunology, University of Pittsburgh, Pittsburgh, PA, United States; ws Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States; wt Department of Radiation Oncology, Thomas Jefferson University and Hospitals, Philadelphia, PA, United States; wu Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States; wv Laboratory of Systems Biology, Van Andel Research Institute, Grand Rapids, MI, United States; ww Ben May Department for Cancer Research, University of Chicago, Gordon Center for Integrative Sciences, Chicago, IL, United States; wx Institute for Molecular Biosciences, University of Graz, Graz, Austria; wy European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy; wz Department of Biology, University of Modena and Reggio Emilia, Modena, Italy; xa Medical Genetics Branch and UDP Translational Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States; xb San Raffaele Sulmona Institute, L\'Aquila, Italy; xc Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China; xd DZNE (German Center for Neurodegenerative Diseases), CAESAR Research Center, Bonn, Germany; xe Pediatric Research and Electron Microscopy Unit, Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; xf Nanjing Agricultural University, College of Veterinary Medicine, Nanjing, China; xg Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States; xh Feinstein Institute for Medical Research, Manhasset, NY, United States; xi University of Ottawa Heart Institute, Ottawa, ON, Canada; xj Department of Medical and Molecular Genetics, Kings College London, London, United Kingdom; xk Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy; xl School of Clinical Medicine, Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, United Kingdom; xm Department of Genomics, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran; xn INSERM, U848, Institut Gustave Roussy, Villejuif (Paris), France; xo Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece; xp Department of Genetics, Smurfit Institute, Trinity College, Dublin, Ireland; xq University Montpellier 2, Institut des Sciences de l\'Evolution, Montpellier, France; xr Department of Pharmacology, University of Antwerp, Antwerp, Belgium; xs Neurodegenerative Diseases Research Group, Vall d\'Hebron Research Institute-CIBERNED, Barcelona, Spain; xt Department of General Pathology, University of Pisa, Pisa, Italy; xu National Institute of Health, Department of Therapeutic Research and Medicine Evaluation, Section of Cell Aging and Degeneration, Rome, Italy; xv Laboratory of Toxicology, Osaka Prefecture University Graduate School of Life and Environmental Biosciences, Izumisano, Japan; xw Department de Biochimie, Université de Lausanne, Lausanne, Switzerland; xx Institute of Developmental Biology and Cancer Research, University of Nice, Centre Antoine Lacassagne, Nice, France; xy Departments of Urology and Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, United States; xz Malaghan Institute of Medical Research, Wellington, New Zealand; ya Department of Biomedical Science, Bond University, Robina, QLD, Australia; yb Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States; yc Cork Cancer Research Centre, University College, Cork, Cork, Ireland; yd Department of Neurology, Vanderbilt University, Nashville, TN, United States; ye Departments of Pediatrics and Biochemistry and Molecular Biology, Atlantic Research Centre, Dalhousie University, Halifax, NS, Canada; yf Department of Medical Biochemistry, Academic Medical Center, Amsterdam, Netherlands; yg Graduate Center of the City, University of New York, New York, NY, United States; yh Department of Cell Biology, Yale University, New Haven, CT, United States; yi IDI-IRCCS Laboratory, University Tor Vergata, Rome, Italy; yj Department of Neurobiology, Hospital Ramon Y Cajal, Madrid, Spain; yk Catalan Institute of Oncology (ICO), Girona Biomedical Research Institute (IDIBGi), Catalonia, Spain; yl Laboratório de Biologia Celular, Instituto Oswaldo Cruz-FIOCRUZ, Rio de Janeiro, RJ, Brazil; ym Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom; yn Department of Hematology/Oncology, University of Cincinnati, Cincinnati, OH, United States; yo Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, United States; yp Bernhard-Nocht-Institut für Tropenmedizin, Tropenmedizinische Grundlagenforschung, Hamburg, Germany; yq Department of Pharmacology, Second Military Medical University, Shanghai, China; yr Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China; ys URBC-NARILIS, University of Namur-FUNDP, Namur, Belgium; yt Department of Molecular Immunology and Gene Therapy, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany; yu Department of Human Pathology and Oncology, Section of Pathological Anatomy, University of Siena, Siena, Italy; yv Lab. of Integrin Signaling, Van Andel Research Institute, Grand Rapids, MI, United States; yw First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece; yx Department of Biochemistry, Tokyo Medical University, Tokyo, Japan; yy Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan; yz Equipe Labellisée par l\'Association Pour la Recherche sur le Cancer (ARC), Villejuif, France; za Department of Clinical and Experimental Medicine, Division of Cell Biology, Linkping University, Linkping, Sweden; zb Grup de Recerca en Patologia Pancreatica, Institut de Recerca Hospital Universitari Vall d\'Hebron, Barcelona, Spain; zc Ecole Normale Supérieure de Lyon, Laboratory of Molecular Biology of the Cell, CNRS UMR 5239, Lyon, France; zd Center for Medical Science, International University of Health and Welfare, Tochigi, Japan; ze Department of Internal Medicine, University of Iowa, Iowa City, IA, United States; zf Department of Anatomy and Neurobiology, University of Maryland, Baltimore, MD, United States; zg Plymouth Marine Laboratory, Plymouth, United Kingdom; zh Faculty of Microbiology, Centro de Investigación en Estructuras Microscópicas CIEMIC, University of Costa Rica, Costa Rica; zi Department of Regulatory Biology, Graduate School of Science and Engineering, Saitama University, Saitama, Japan; zj Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, London, United Kingdom; zk Wellcome Trust Centre for Molecular Parasitology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom; zl Department of Neuroscience, Georgetown University Medical Center, Washington, DC, United States; zm IRCCS Saverio de Bellis, Castellana Grotte (Ba), Italy; zn Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland; zo Novartis Institutes for Biomedical Research, Cambridge, MA, United States; zp Molecular and Cellular Oncogenesis, Wistar Institute, Philadelphia, PA, United States; zq DAHFMO, Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy; zr Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, United States; zs Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan; zt Laboratory of Molecular and Cellular Biology, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan; zu Central Laboratory of Hematology, University Hospital of Lausanne, Lausanne, Switzerland; zv Department of Neurobiology, Gifu University Graduate School of Medicine, Gifu, Japan; zw Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan; zx Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan; zy Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, Tampa, FL, United States; zz Biochemistry Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; aaa Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom; aab Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; aac Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, United States; aad Department of Cell and Molecular Biology, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; aae Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany; aaf Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Simmons Cancer Institute, Springfield, IL, United States; aag Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo, Japan; aah Donnelly Centre, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; aai Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United States; aaj School of Medicine, University of Split, Split, Croatia; aak Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan; aal Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Wako, Saitama, Japan; aam Center for Plant Molecular Biology, Eberhard-Karls-University, Tübingen, Germany; aan Departments of Pathology, Laboratory Medicine, University of Wisconsin, Madison, WI, United States; aao Department of Physiology, South Texas Research Facility, University of Texas Health Science Center, San Antonio, TX, United States; aap Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; aaq Department of Gene Therapy, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan; aar Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan; aas Laboratory of Mitochondrial Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan; aat Department of Radiation Oncology, Case Western Reserve University, Cleveland, OH, United States; aau Department of Biochemistry;and Environmental Health Sciences, Case Western Reserve University, Cleveland, OH, United States; aav University of Copenhagen, Department of Agriculture and Ecology, Frederiksberg C, Denmark; aaw Ecole Polytechnique Fédérale de Lausanne, School of Life Sciences, Global Health Institute, Lausanne, Switzerland; aax Sanford-Burnham Medical Research Institute at Lake Nona, Orlando FL, United States; aay Pacific Biosciences Research Center, University of Hawaii, Honolulu, HI, United States; aaz Cardiovascular Division, King\'s College London, London, United Kingdom; aba AC Immune SA, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland; abb INSERM U775, Université Paris Descartes, Paris, France; abc Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, LA, United States; abd Department of Neurology, Baylor College of Medicine, Houston, TX, United States; abe Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA, United States; abf Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis Zografou, Athens, Greece; abg Molecular and Clinical Pharmacology, Faculty of Medicine, University of Chile, Santiago, Chile; abh Division of Biological Science and Technology, Yonsei University, Wonju, South Korea; abi Departmenet of Internal Medicine, University of Goettingen, Gttingen, Niedersachsen, Germany; abj UNC Mcallister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; abk Department of Dermatology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, United States; abl Institute of Entomology, Central China Normal University, Wuhan, China; abm Department of Pediatrics, University of Pittsburgh School of Medicine, Children\'s Hospital of Pittsburgh, Pittsburgh, PA, United States; abn Department of Ecology, University of Calabria, Rende, CS, Italy; abo Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, TX, United States; abp Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore, Singapore; abq Institute of Biochemistry, ETH Zurich, Zurich, Switzerland; abr Department of Medical Oncology, VU University Medical Center, Amsterdam, Netherlands; abs Department of Biology, University of Copenhagen, Copenhagen, Denmark; abt Departments of Ophthalmology and Biochemistry and Molecular Biology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary; abu CNRS, Faculté de Médecine, Université de Nice Sophia Antipolis, Nice, France; abv CNRS, UMR 8122, Institut Gustave Roussy, Villejuif, France; abw Department of Neurobiology, Tel-Aviv University, Ramat-Aviv, Tel-Aviv, Israel; abx Neuroscience Institute Cavalieri-Ottolenghi (NICO), University of Turin, Orbassano, TO, Italy; aby Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA, United States; abz Robert H. Lurie Comprehensive Cancer Center, Division of Hematology/Oncology, Northwestern University Medical School, Chicago, IL, United States; aca Institute of Microbiology and Genetics, Department Genetics of Eukaryotic Microorganisms, Georg-August-University, Goettingen, Germany; acb Institut Claudius Regaud, Toulouse, France; acc Universita\' degli Studi di Milano, Centro di Eccellenza Sulle Malattie Neurodegenerative, Universita\' degli Studi di Milano, Milano, Italy; acd EA4530, Dynamique des Microtubules en Physiopathologie, Université Paris-Sud 11, Chatenay-Malabry, France; ace Centro Andaluz de Biología Molecular Y Medicina Regenerativa, CSIC, Sevilla, Spain; acf Department of Molecular and Cellular Biochemistry, Ohio State University, Columbus, OH, United States; acg Division of Experimental Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; ach Institute for Research in Ophthalmology (IRO), Sion, Switzerland; aci Center for Molecular Microbiology, Department of Oral Biology, University of Florida, Gainesville, FL, United States; acj Department of Molecular Biology, University of Tuebingen, Tuebingen, Germany; ack Center for Motor Neuron Biology and Disease, Columbia University, New York, NY, United States; acl Cardiovascular Research Institute, Departments of Physiology and Emergency Medicine, Wayne State University School of Medicine, Detroit, MI, United States; acm Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States; acn Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States; aco Institute of Basic Medical Sciences, School of Basic Medicine, Departments of Physiology and Pathology, Beijing, China; acp Department of Pharmacology, Soochow University School of Pharmaceutical Science, Suzhou, China; acq Samuel Lunenfeld Research Institute, University of Toronto, Toronto, ON, Canada; acr Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, United States; acs Department of Medicine, University of British Columbia, Vancouver, BC, Canada; act Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, United States; acu Institute of Cellular and Molecular Anatomy, Clinics of the JWG-University, Frankfurt, Germany; acv Monash Micro Imaging, Monash University, Clayton Campus, Melbourne, VIC, Australia; acw Department of Microbiology, University of Chicago, Chicago, IL, United States; acx MRC Laboratory of Molecular Biology, Cambridge, United Kingdom; acy Laboratory of Biochemistry, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, United States; acz Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, United States; ada Neurodegenerative Disease Research, EMD Serono Research Institute, Inc., Billerica, MA, United States; adb Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States; adc Department of Biology, University of Waterloo, Waterloo, ON, Canada; add Division of Tumor Virology, German Cancer Research Center, Heidelberg, Germany; ade Mitochondrial Biology, Zentrum für Molekulare Medizin, Goethe Universitt Frankfurt am Main, Frankfurt am Main, Germany; adf Institute of Environmental Health Sciences, Wayne State University, Detroit, MI, United States; adg Pharmacology, University of Wyoming College of Health Sciences, Laramie, WY, United States; adh Kovler Diabetes Center, University of Chicago, Chicago, IL, United States; adi Departamento de Morfologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; adj Department of Pediatrics, Cincinnati Children\'s Hospital, Cincinnati, OH, United States; adk Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada; adl Department of Urology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, United States; adm Service de Dermatologie, Hpital Archet II, CHU Nice, France; adn Centro de Investigaciones Biológicas (CSIC), Ciber de Enfermedades Raras, Madrid, Spain; ado Ophthalmology, and Neurosciences Division, Medical University of South Carolina, Charleston, SC, United States; adp Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, United States; adq Department of Animal Histology and Embryology, University of Silesia, Katowice, Poland; adr Unité de Recherche 04;Vieillissement;Stress et Inflammation, Université Pierre et Marie Curie (UPMC), Paris, France; ads Department of Radiation Oncology (Maastro Lab.), GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, Netherlands; adt Departments of Molecular Genetics and Anatomic Pathology, Lerner Research Institute, Taussig Cancer Center, Cleveland, OH, United States; adu Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Eppendorf, Hamburg, Germany; adv Dearptment of Clinical Biochemisty, National Institute of Biotechnology Negev, Ben-Gurion University, Beer-Sheva, Israel; adw Department of Medical Biology and Genetics, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic; adx Boston University, School of Medicine, Section of Molecular Medicine, Boston, MA, United States; ady Department of Pharmacobiology, University of Calabria, Arcavacata di Rende, Italy; adz Department of Biology, Massachusetts Institute of Technology, Whitehead Institute, Cambridge, MA, United States; aea Whitehead Institute, Cambridge, MA, United States; aeb Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, United States; aec Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, Japan; aed Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan; aee Department of Systems Biology, Agricultural Biotechnology Research Institute of Iran, Karaj, Iran; aef Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, United Kingdom; aeg Division of Neuroscience, Beckman Research Institute of the City of Hope, Duarte, CA, United States; aeh Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; aei Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-Consejo Superior de Investigaciones Cientificas-Junta de Andalucia, Sevilla, Spain; aej Laboratorio de Oncologia Molecular, CRIB-PcyTA, Universidad de Castilla la Mancha, Albacete, Spain; aek Dulbecco Telethon Institute, Padova, Italy; ael Venetian Institute of Molecular Medicine, Padova, Italy; aem Department of Pharmacology and Toxicology, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United States; aen Department of Pediatrics, Stanford University, Stanford, CA, United States; aeo Department of Immunology and Microbiology, Albert Einstein College of Medicine, Bronx, NY, United States; aep Jawaharlal Nehru University, School of Life Sciences, New Delhi, India; aeq Departments of Immunology and Surgery, Stanford University, Stanford, CA, United States; aer Department of Biochemistry and Biophysics, Vilnius University, Vilnius, Lithuania; aes Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan; aet Division of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland; aeu Departments of Veterinary Sciences and Molecular Biology, University of Wyoming, Laramie, WY, United States; aev Departments of Genome Analysis and Neurology, Academic Medical Center, Amsterdam, Netherlands; aew Sektion Experimentelle Ansthesiologie, Universittsklinikum Ulm, Ulm, Germany; aex Experimental Tumor Patholology, Institute of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany; aey Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA, United States; aez Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausane, Switzerland; afa DAGZ, Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria; afb Memorial Hospital Research Laboratories, Memorial Sloan-Kettering Cancer Center, Medicine, New York, NY, United States; afc Department of Cell Physiology and Medicine, University of Geneva, Geneva, Switzerland; afd Department of Molecular Physiology and Biophysics, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, United States; afe Department of Cell Biology, Institute for Cancer Research, Rikshospitalet-Radiumhospitalet HF, Montebello, Oslo, Norway; aff GRECC, VA Medical Center, Durham, NC, United States; afg INRA, UR1067 Nutrition Métabolisme et Aquaculture, Saint-Pée-sur-Nivelle, France; afh Department of Surgery, St. Jude Children\'s Research Hospital, Memphis, TN, United States; afi Department of Pathology, Drexel University College of Medicine, Philadelphia, PA, United States; afj Integrating Proteomics and Metabolomics Research Team, Korea Basic Science Institute, Seoul, South Korea; afk Department of Pharmaceutical Sciences, Wayne State University College of Pharmacy, Detroit, MI, United States; afl Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; afm Near-Future Locomoter Organ Medicine Creation Course (Kusunoki Kai), Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima, Japan; afn Department of Pathology, University of Alabama at Birmingham, Birmingham VAMC, Birmingham, AL, United States; afo Department of Orthopaedic Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, United States; afp Department of Biochemistry and Molecular Biology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel; afq Howard Hughes Medical Institute, Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, San Diego, CA, United States; afr Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, United States; afs Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; aft University of Southern California School of Pharmacy, Los Angeles, CA, United States; afu Synaptic Function Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States; afv Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States; afw National Institute of Floricultural Science, National Agriculture and Food Research Organization (NARO), Tsukuba, Japan; afx Laboratory of Molecular and Cellular Biology, Graduate School of Human Health Science, University of Nagasaki, Nagayo, Nagasaki, Japan; afy Institute of Biomedical Sciences, College of Life Sciences, National Chung Hsing University, Taichung, Taiwan; afz Department of Biochemistry, School of Medicine, Taipei Medical University, Taipei, Taiwan; aga Department of Pathological Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan; agb Laboratory of Bioindustrial Genomics, Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan; agc Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA, United States; agd Department of Biochemistry, Goodman Cancer Center, McGill University, Montreal, QC, Canada; age Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine; agf Cancer Genetics, Kolling Institute of Medical Research, University of Sydney and Royal North Shore Hospital, NSW, Australia; agg MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom; agh Nuffield Department of Medicine, Oxford, United Kingdom; agi Institute of Pharmacology, University of Bern, Bern, Switzerland; agj Laboratory of Signal-Dependent Transcription, DTP, Consorzio Mario Negri Sud, Santa Maria Imbaro (Ch), Italy; agk Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; agl Department of Genetics, Harvard Medical School, Boston, MA, United States; agm Department of Medicine and Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY, United States; agn Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States; ago Division of Oncology, Mayo Clinic and Mayo Cancer Center, Rochester, MN, United States; agp Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong; agq Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague, Czech Republic; agr A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russian Federation; ags Department of Pharmacology, Federal University of So Paulo, School of Medicine, So Paulo, Brazil; agt Institute of Molecular Biosciences, Center for Emerging and Neglected Infectious Diseases, Mahidol University, Thailand; agu Melanoma Laboratory, Spanish Cancer Research Centre, Madrid, Spain; agv Department of Biochemistry, University of Geneva, Geneva, Switzerland; agw Department of Neurology, Second Hospital of Hebei Medical University, Institute of Cardiocerebrovascular Disease, Shijiazhuang, Hebei, China; agx Departments of Gynecologic Oncology and Cancer Biology, Center for RNA Interference and Non-Coding RNA, MD Anderson Cancer Center, Houston, TX, United States; agy Pediatric Infectious Disease, University of California, San Diego, San Diego, CA, United States; agz Department of Anaesthesiology and Intensive Care Medicine, Campus Virchow-Klinikum, Charité-Universitaetsmedizin Berlin, Berlin, Germany; aha Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States; ahb Department of Biology, Indian Institute of Science Education and Research, Trivandrum, Kerala, India; ahc Laboratory of Neurodegenerative Diseases, Biomedical Research Foundation of the Academy of Athens, Athens, Greece; ahd Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, United States; ahe Department of Neurosurgery, Charité-University Medicine Berlin, Berlin, Germany; ahf Division of Medicine, University College, London, United Kingdom; ahg Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., Frederick, MD, United States; ahh Laboratory of Translational Research, Clinical Research, National Cancer Institute of Brazil, Rio de Janeiro, Brazil; ahi Institute of Molecular Medicine, Heinrich-Heine-University, Düsseldorf, Germany; ahj Departments of Ophthalmology and Medicine, Case Western Reserve University School of Medicine, Institute of Pathology, Cleveland, OH, United States; ahk Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China; ahl Department of Psychiatry, Columbia University Medical Center, New York, NY, United States; ahm Department of Microbiol Immunology, University of Texas Medical Branch, Galveston, TX, United States; ahn State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), School and Hospital of Stomatology, Wuhan University, Wuhan, China; aho Institute of Digestive Diseases, Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, Hong Kong; ahp Bioimaging Center, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan; ahq Department of Molecular Bacteriology and Immunology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan; ahr Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, United States; ahs Department of Biology, University of York, Heslington, York, United Kingdom; aht Department of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, United Kingdom; ahu Division of Cardiology, Department of Medicine, University of Texas Medical School at Houston, Houston, TX, United States; ahv Department of Experimental Medicine, University of Rome Sapienza, Rome, Italy; ahw Department of Genetics, Etvs Loránd University, Budapest, Hungary; ahx Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan; ahy Department of Bioscience and Biotechnology, Kyushu University, Kyushu, Japan; ahz Department of Molecular Biodefense Research, Yokohama City University Graduate School of Medicine, Yokohama, Japan; aia School of Biosciences, University of Exeter, Exeter, United Kingdom; aib Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; aic Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, Miyagi, Japan; aid State Key Laboratory of Plant Cell and Chromosome Engineering, Chinese Academy of Sciences, Beijing, China; aie Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China; aif Laboratory of Biomembranes, Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan; aig Laboratory of Experimental Therapeutics and Molecular Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States; aih CRUK Institute for Cancer Studies, University of Birmingham, Birmingham, United Kingdom; aii Division of Geriatrics, Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, United States; aij Developmental Neurobiology, St. Jude Children\'s Research Hospital, Memphis, TN, United States; aik Department of Clinical Pathology and Cytology, Karolinska University Hospital in Huddinge, Stockholm, Sweden; ail Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy; aim Centre of Microbial and Plant Genetics (CMPG), Katholieke Universiteit Leuven, Leuven, Belgium; ain Department of Pharmacology, University of Colorado School of Medicine, Denver, CO, United States; aio Department Biochemistry II, Georg-August-Universitaet, Goettingen, Germany; aip Department of Neurology, Okayama University Medical School, Okayama City, Japan; aiq Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; air Secretory Pathways Laboratory, Cancer Research UK London Research Institute, London, United Kingdom; ais Faculty of Life Sciences, University of Manchester, Manchester, Lancashire, United Kingdom; ait Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA, United States; aiu Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, Belgrade, Serbia; aiv Laboratory of Respiration Physiology, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; aiw Department of Life Sciences, Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan; aix Departments of Clinical Research and Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland; aiy Laboratory of Immunology, Graduate School of Biomedical Sciences, Tokyo Medical and Dental University, Tokyo, Japan; aiz Division of Transplantation, Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States; aja Department of Biochemistry and Molecular and Structural Biology, J. Stefan Institute, Ljubljana, Slovenia; ajb Department of Biology, Francis Marion University, Florence, SC, United States; ajc Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY, United States; ajd Department of Neurology, Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, United States; aje IRCCS Casa Sollievo Della Sofferenza, CSS-Mendel Laboratory, San Giovanni Rotondo, Italy; ajf Mann Laboratory, Department of Plant Sciences, University of California, Davis, CA, United States; ajg Microbiology and Immunology Departments, University of Colorado School of Medicine, Aurora, CO, United States; ajh Departments of Molecular and Cell Biololgy and Immunology/Surgery, VU University Medical Center, Amsterdam, Netherlands; aji Liver Cell Biology Laboratory, Department of Cell Biology, Vrije Universiteit Brussel, Brussels, Belgium; ajj Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, Ghent University, Ghent, Belgium; ajk Department of Neurology, University Hospitals Leuven, Leuven, Belgium; ajl Hospital Clínic, Division of Gastroenterology, CiberEHD, Barcelona, Catalonia, Spain; ajm Department of Biochemistry and Molecular Biology I, Complutense University, School of Biology, Madrid, Spain; ajn Department of Biochemistry and Molecular Biology, Autonomous University of Barcelona (UAB), Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain; ajo INSERM U1048, Toulouse, France; ajp Department of Pediatrics, Laboratory of Oncohematology, University of Padova, Padova, Italy; ajq Experimental Neurorehabilitation Lab, IRCSS Santa Lucia Foundation, Rome, Italy; ajr Laboratory of Plant Ecological Physiology, Komarov Botanical Institute, Russian Academy of Sciences, St. Petersburg, Russian Federation; ajs Visual Neuroscience and Molecular Biology Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom; ajt Texas A and M Institute for Biosciences and Technology, Houston, TX, United States; aju Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA, United States; ajv Department of Neurology, University of Bonn, Bonn, Germany; ajw Department of Medical Oncology, Sun Yat-sen University, Guangzhou, China; ajx Cleveland Clinic Foundation, Biomedical Engineering, Cleveland, OH, United States; ajy Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, United States; ajz Department of Cell Biology, Duke University Medical Center, Durham, NC, United States; aka Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY, United States; akb Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan; akc Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, United States; akd Protein Quality Control and Degradation Research Center, Sanford School of Medicine, University of South Dakota, Vermillion, SD, United States; ake Department of Environmental and Occupational Health, National Cheng Kung University, Medical College, Tainan, Taiwan; akf Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; akg Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, United States; akh Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China; aki Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands; akj Department of Pathology, University of Utah, School of Medicine, Salt Lake City, UT, United States; akk Juntendo University Graduate School of Medicine, Department of Metabolism and Endocrinology, Tokyo, Japan; akl Randall Division for Cell and Molecular Biophysics, Kings College, London, United Kingdom; akm House Research Institute, Los Angeles, CA, United States; akn Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai, China; ako Department of Neurology, Washington University School of Medicine, Saint Louis, MO, United States; akp School of Life Science, University of Science and Technology of China, Hefei, Anhui, China; akq MRC Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom; akr University of East Anglia, Faculty of Health, Biomedical Research Centre, Norwich, East Anglia, United Kingdom; aks Edinburgh CRUK Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom; akt Institute of Physical Biology, Heinrich-Heine-Universitt, Düsseldorf, Germany; aku Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States; akv University Health Network, Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, ON, Canada; akw Fujian University of Traditional Chinese Medicine, Fuzhou, China; akx Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi\'an Jiaotong University, Xi\'an, China; aky School of Biological Sciences, Life Sciences Building, University of Southampton, Southampton, United Kingdom; akz Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States; ala Department of Urology, Peking University First Hospital, Beijing, China; alb Centenary Institute, Sydney Medical School University of Sydney, Sydney, NSW, Australia; alc State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; ald School of Medicine, Nankai University, Tianjin, China; ale Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; alf Department of Gastric and Pancreatic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, China; alg College of Bioengineering, Henan University of Technology, Zhengzhou, China; alh Departments of Molecular Biosciences, Urology and Radiation Oncology, University of Kansas, Lawrence, KS, United States; ali Department of Biochemistry and Molecular Biology, Mayo Clinic, College of Medicine, Rochester, MN, United States; alj Department of Cell Biology, Nagahama Institute of Bio-Science and Technology, Nagahama, Japan; alk Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan; all National Research Institute of Fisheries Science, Yokohama, Japan; alm College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, China; aln OIST Graduate University, Okinawa, Japan; alo Department of Pediatrics, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States; alp Division of Surgery and Interventional Science, University College London, London, United Kingdom; alq Weis Center for Research, Geisinger Clinic, Danville, PA, United States; alr Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan; als Department of Pathology, Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, United States; alt BioMedical Research Center, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea; alu Department of Biochemistry, Ajou University School of Medicine, Suwon, South Korea; alv Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan; alw School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan; alx INRA, UMR1318, Institut Jean-Pierre Bourgin, Versailles, France; aly Department of Pharmacology, DNA Repair Research Center, Chosun University School of Medicine, Gwangju, South Korea; alz Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX, United States; ama State Key Laboratory of Genetics Engineering, School of Life Sciences, Fudan University, Shanghai, China; amb Department of Radiation Oncology, University of Texas Health Science Center San Antonio, San Antonio, TX, United States; amc Department of Neurology and Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, United States; amd Protein Engineering and Comparative Immunology, Graduate School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea; ame Department of Neurophysiology, Keio University School of Medicine, Tokyo, Japan; amf University of Messina, Messina, Italy; amg Department of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, MI, United States; amh Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, ON, Canada; ami Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; amj Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States; amk Department of Neuroscience, University of Virginia, Charlottesville, VA, United States; aml National Institute of Biological Sciences, Beijing, China; amm Laboratory of Cerebrovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou, China; amn Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; amo Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands; amp Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; amq School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia; amr Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Health Science Center, Beijing, China; ams Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China; amt Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States; amu Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, China; amv Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States; amw Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; amx Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, China; amy Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, United States; amz Institute for Research in Biomedicine, CIBERDEM, Universitat de Barcelona, Barcelona, Spain; ana Max Planck Institute of Psychiatry, Munich, Germany; anb Department of General Surgery, University of Pittsburgh Medical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, United States; anc CHU-Nice, Laboratoire de Pathologie Clinique et Expérimentale, Nice, France; and Department of Molecular Genetics, Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ane IRCCS Neuromed, Pozzilli, Italy; anf Department of Cell Signaling, Gifu University Graduate School of Medicine, Gifu, Japan; ang Cancer Institute of New Jersey, New Brunswick, NJ, United States; anh Université de Lyon, Lyon, France; ani Breakthrough Breast Cancer Research Unit, University of Manchester, Manchester, United Kingdom; anj Medical School-University of Crete, Heraklion, Crete, Greece; ank University of Tsukuba, Ibaraki, Japan; anl Santo Tomas University, Via del Mar, Chile; anm Department of Biology, University of Mainz, Mainz, Germany; ann University of Rzeszow, Rzeszow, Poland）

出处： Autophagy 2012 Vol.8 No.4 P445-544

关键词： Autolysosome;Autophagosome;Flux;LC3;Lysosome;Phagophore;Stress;Vacuole

摘要： In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelera ...

作者： Wu X.-Y.;Zhang G.-X. （Department of Radiology, Baoshan Branch of Shanghai First People\'s Hospital, Shanghai 200940, China Department of Radiology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China）

出处： Chinese Journal of Medical Imaging Technology 2012 Vol.28 No.11 P2094-2097

关键词： Breast neoplasms;Diffusion magnetic resonance imaging

摘要： Breast cancer has become one of the female malignant tumors with highest incidence globally. Meanwhile, it is the most common cause for tumor related ...

作者： Wang H.;Sun X.;Liu K.;Xu X. （Department of Ophthalmology, Shanghai First People\'s Hospital, Affiliate of Shanghai Jiaotong University, No. 100 Haining Road, Shanghai 200080, China）

出处： Current Eye Research 2012 Vol.37 No.8 P661-670

关键词： Angiogenesis;Anti-VEGF;Diabetic macular edema;Lucentis;Ranibizumab

摘要： Purpose: To evaluate the therapeutic effect and safety of intravitreal ranibizumab (RBZ) or RBZ combined with focal/grid laser in diabetic macular ede ...

作者： Zhu D.;Zhou J.;Xu X. （Department of Ophthalmology, Shanghai First People\'s Hospital, Shanghai, China Department of Ophthalmology, Shanghai Ninth People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Current Eye Research 2012 Vol.37 No.11 P1025-1029

关键词： Lactate;Pigment epithelium-derived factor;Retina;Tissue culture techniques;Vascular endothelial growth factors

摘要： Purpose: To investigate the influence of lactate on expression of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PED ...

作者： Tong, N.;Zhang, Z.;Gong, Y.;Yin, L.;Wu, X. （Department of Ophthalmology, Shanghai Jiaotong University, Affiliated Shanghai First People\'s Hospital, Shanghai 200080, China）

出处： Journal of Ocular Pharmacology and Therapeutics 2012 Vol.28 No.5 P459-466

摘要： Objective: Diosmin, a natural flavone glycoside, possesses antioxidant activity and has been used to alleviate ischemia/reperfusion (I/R) injury. The ...

作者： Zhou, L.;Yin, B.;Liu, Y.;Hong, Y.;Zhang, C.;Fan, J. （Department of Urology, Shanghai Jiaotong University, Shanghai First People\'s Hospital, 85 Wujin Road, Shanghai, 200080, China）

出处： Journal of Surgical Oncology 2012 Vol.105 No.8 P841-847

关键词： FOXO1;miR-27a;proliferation;renal cell carcinoma

摘要： Background and Objectives Forkhead box O-class 1 (FOXO1), a putative tumor suppressor, is dysregulated in many cancers. Our study aims to reveal the u ...

作者： Zhang Z.;Qin X.;Zhao X.;Tong N.;Gong Y.;Zhang W.;Wu X. （Department of Ophthalmology, Shanghai Jiaotong University, Affiliated Shanghai First People\'s Hospital, Wujin Road 85, Shanghai, 200080, China Department of Ophthalmology, First Affiliated Hospital of Dalian Medical University, DaLian, Liaoning Province, China Central Laboratory, Shanghai Jiaotong University, Affiliated Shanghai First People\'s Hospital, Shanghai, China）

出处： Current Eye Research 2012 Vol.37 No.5 P429-437

关键词： Apoptosis;Ischemia/Reperfusion injury;Oxidative stress;Retina;Valproic acid

摘要： Purposes: To investigate whether valproic acid (VPA) has a neuroprotective effect against ischemia/reperfusion (I/R) injury in the rat retina, and to ...

作者： Wei, Y.;Ouyang, P.;Yang, W. （a Department of Cardiovasology, Songjiang Branch to Shanghai First People\'s Hospital, Shanghai Jiao Tong University, Shanghai 201600, China; b Department of General Intensive Care Unit, Songjiang Branch to Shanghai First People\'s Hospital, Shanghai Jiao Tong University, Shanghai 201600, China）

出处： Journal of Huazhong University of Science and Technology - Medical Science 2012 Vol.32 No.1 P149-150

关键词： Inferior vena cava filter;Postpartum;Pulmonary embolism;Thrombosis

摘要： Postpartum inferior vena cava (IVC) thrombosis is a rare, but potentially life-threatening disorder. Here we reported one case of the youngest woman t ...

作者： Han, Z.-B.;Chen, H.-Y.;Fan, J.-W.;Wu, J.-Y.;Tang, H.-M.;Peng, Z.-H. （a Department of General Surgery, Shanghai First People\'s Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai 200080, China; b Department of Pathology, Shanghai First People\'s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China）

出处： Journal of Cancer Research and Clinical Oncology 2012 Vol.138 No.1 P153-161

关键词： Hepatocellular carcinoma;Liver transplantation;MicroRNA-155;Prognosis;Recurrence

摘要： Purpose: MicroRNAs play important roles in cancer development, progression, and metastasis. The aim of this study was to determine whether altered mic ...