仓储作者

吴云成

职称：主任医师、博导
研究方向：脑血管病、帕金森病和运动障碍疾病（如不安腿综合征、特发性震颤、肌张力障碍、抽动症、舞蹈症、发作性运动障碍等）、睡眠障碍、记忆障碍的临床诊治。
所属科室：神经内科
成果数量：9条，属于本单位的个人成果9条
简介：医学博士，主任医师，教授，博士生导师，市一医院神经内科主任。美国德州医学中心Baylor College of Medicine神经病学系博士后，师从世界帕金森病与运动障碍疾病协会主席Joseph Jankovic教授；德州医学中心Methodist Hospital脑血管病中心访问学者，师从David Chiu教授。先后获“优秀青年医学...
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[中文专利] HIF-1α小分子激活剂在制备用于治疗神经退行性疾病的药物中的应用

发明人：吴云成，尹慧勇，李璇

申请人：上海市第一人民医院

申请号： 201810946300.7

申请日期： 2018.08.17

摘要：本发明涉及生物医药技术领域，具体地涉及HIF‑1α小分子激活剂在治疗神经退行性疾病特别是帕金森病中的应用。

[中文专利] HIF‑1α小分子激活剂FG‑4592在帕金森病中的应用

发明人：吴云成，尹慧勇，李璇

申请人：上海市第一人民医院

申请号： 201710713232.5

申请日期： 2017.08.18

摘要：本发明涉及HIF‑1α小分子激活剂FG‑4592的一种新用途，属于生物医药技术领域，即FG‑4592在制备治疗帕金森病的药物中的应用。其优点表现在：化合物处于三期临床试验，不需要再对其临床药理学及人体安全性评价进行探究，利于成果转化。本发明通过在帕金森病细胞及动物模型中的研究发现，相对于模型组，FG ...

[外文期刊] Stable suppression of Nurr1 gene using sirna expression vector in a mouse midbrain dopaminergic cell line SCIE SCI

作者： Wu, Y. C.;Zhao, Y. B.;Cai, Y. Q.;Fei, J.

出处： EUROPEAN JOURNAL OF NEUROLOGY 2006 Vol.13 P84

[外文期刊] A clinical memory battery for screening for amnestic mild cognitive impairment in an elderly chinese population SCI

作者： Zhao, Shengjie;Guo, Chunni;Wang, Mingqin;Chen, Weijie;Wu, Yuncheng;Tang, Wei;Zhao, Yongbo

出处： JOURNAL OF CLINICAL NEUROSCIENCE 2011 Vol.18 No.6 P774-779

摘要： Amnestic mild cognitive impairment (MCI) might be more likely to progress to Alzheimer\'s disease than single non-memory MCI and multiple domain MCI. ...

[外文期刊] Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral lschemia SCI

作者： Lu, Haiyan;Song, Xiaoyan;Wang, Feng;Wang, Guodong;Wu, Yuncheng;Wang, Qiaoshu;Wang, Yongting;Yang, Guo-Yuan;Zhang, Zhijun

出处： FRONTIERS IN CELLULAR NEUROSCIENCE 2016 Vol.10

摘要： Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral i ...

[外文期刊] Magnetofection based on superparamagnetic iron oxide nanoparticle-mediated low lncRNA HOTAIR expression decreases the proliferation and invasion of glioma stem cells SCIE SCI

作者： Fang, Kan;Liu, Peifeng;Dong, Suyan;Guo, Yanjie;Cui, Xinxin;Zhu, Xiaoying;Li, Xuan;Jiang, Lianghan;Liu, Te;Wu, Yuncheng

出处： INTERNATIONAL JOURNAL OF ONCOLOGY 2016 Vol.49 No.2 P509-518

摘要： Glioma stem cells (GSCs) are a special subpopulation of glioma cells that are key to the sensitivity of tumors to treatments and to the possibility of ...

[外文期刊] CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer\'s disease SCIE SCI

作者： Zhang, Lihang;Xu, Juan;Gao, Jinchao;Wu, Yuncheng;Yin, Ming;Zhao, Wenjuan

出处： REVIEWS IN THE NEUROSCIENCES 2018 Vol.29 No.8 P837-848

摘要： Neurons and microglia are two major components in the central nervous system (CNS). The interactions between them play important roles in maintaining ...

[外文期刊] Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

作者： Lin, Xiao-Wei;Zhang, Jun-Fang;Qiu, Meng-Yao;Ni, Ling-Yan;Yu, Hong-Lei;Kuo, Sheng-Han;Ondo, William G.;Yu, Qing;Wu, Yun-Cheng

出处： BMC NEUROLOGY 2019 Vol.19

摘要： BackgroundThe prevalence of Restless legs syndrome (RLS) in End Stage Renal Disease (ESRD) patients is higher than that in the general population. How ...

[外文期刊] Clinical features and subtypes of restless legs syndrome in Chinese population: a study of 359 patients SCI

作者： Zhu, Xiao-Ying;Wu, Ting-Ting;Wang, Hong-Ming;Ni, Ling-Yan;Li, Xuan;Liu, Ye;Zhang, Xiao-Jin;Chen, Ya-Jing;Cui, Xin-Xin;Ondo, William G.;Wu, Yun-Cheng

出处： SLEEP MEDICINE 2019 Vol.59 P15-23

摘要： Background: The clinical spectrum of restless legs syndrome (RLS) has not been described in a Chinese population. We aim to evaluate the detailed clin ...

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