李琦
肿瘤临床医学中心
职称：主任医师、博导
发明人：李琦，谢克平，高勇，田川，董笑
申请日期：2018.01.22
摘要：本发明涉及Klf4作为肝癌疾病诊断和治疗靶点中的应用。本发明首次发现Klf4在肝癌细胞和组织中表达显著降低，该发现为临床诊断HCC及判断活动性提供了重要依据和方法，提示Klf4可作为肝癌及其活动性诊断的生物标志物。进一步将转染Klf4基因的SK‑Hep‑1细胞植入裸鼠腹部皮下，发现裸鼠成瘤能力明显下 ...
发明人：李琦，朱怡雯，蔡讯，宋卫峰，丁红华，周翡，顾鸿莉，王静珏
申请日期：2016.10.21
摘要：本发明涉及一种个体化外周血循环肿瘤细胞联合肿瘤标记物检测对晚期结肠癌患者化疗疗效的评估方法，所述的方法如下：FOLFIRI化疗方案、治疗前d0、d8外周血3.2ml检测CTCs、肿瘤标记物检测、CTCs变化曲线、RECIST 1.1评估、比较3种疗效评估方法的优劣和检测ctDNA基因突变情况。本发明 ...
作者：Xiong, Y.;Yang, H.;Li, Q.
出处：AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2018
作者：Xu, Rui-hua;Wang, Fenghua;Shi, Jianhua;Feng, Ji Feng;Shen, Lin;Yang, Shujun;Hu, Xi-Chun;Dai, Guanghai;Xu, Nong;Jiang, Yi;Yongqian, Shu;Zhang, Qingyuan;Chen, Ye;Yuan, Xianglin;Lin, Xiaoyan;Ba, Yi;Li, Qi;Li
出处：JOURNAL OF CLINICAL ONCOLOGY 2018
作者：Shen, L.;Ying, X.;Li, Q.;Wang, W.;Zhu, L.;Zhao, Q.;Nie, Y.;Zhu, B.;Ma, D.;Lin, X.;Cai, X.;Fang, W.;Peng, C.;Chen, Y.;Fang, H.;Li, H.;Wang, N.;Xu, R.
出处：VALUE IN HEALTH 2018
作者：Tian, Chuan;Yao, Shanshan;Liu, Li;Ding, Youcheng;Ye, Qingwang;Dong, Xiao;Gao, Yong;Yang, Ning;Li, Qi
出处：INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2017
摘要：MicroRNAs (miRNAs or miRs) are short, endogenous non-coding RNA molecules, demonstrating abnormal expression in cancer initiation and progression. In ...
作者：Sui, Hua;Duan, Peiwen;Guo, Piaoting;Hao, Lishuang;Liu, Xuan;Zhang, Jinhua;Zhu, Huirong;Zhao, Miaomiao;Wang, Hao;Li, Qi;Wang, Songpo
出处：ONCOLOGY REPORTS 2017
摘要：Zhi-Zhen-Fang (ZZR), a Traditional Chinese Medicine (TCM) formula, has been clinically used in China to treat drug-resistant colorectal cancer (CRC) p ...
作者：Lin, Yun;Li, Qun;Huang, Wei;Jia, Xinyan;Jiang, Hong;Gao, Yong;Li, Qi
出处：ONCOTARGETS AND THERAPY 2013
摘要：Introduction: To date, no effective systemic therapies have been made available for paraganglioma. However, multiple mutations in susceptibility genes ...
