合作者关系

[中文专利] HIF‑1α小分子激活剂FG‑4592在帕金森病中的应用

发明人：吴云成，尹慧勇，李璇

申请日期：2017.08.18

摘要：本发明涉及HIF‑1α小分子激活剂FG‑4592的一种新用途，属于生物医药技术领域，即FG‑4592在制备治疗帕金森病的药物中的应用。其优点表现在：化合物处于三期临床试验，不需要再对其临床药理学及人体安全性评价进行探究，利于成果转化。本发明通过在帕金森病细胞及动物模型中的研究发现，相对于模型组，FG ...

[中文专利] HIF-1α小分子激活剂在制备用于治疗神经退行性疾病的药物中的应用

发明人：吴云成，尹慧勇，李璇

申请日期：2018.08.17

摘要：本发明涉及生物医药技术领域，具体地涉及HIF‑1α小分子激活剂在治疗神经退行性疾病特别是帕金森病中的应用。

[外文期刊] CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer\'s disease SCIE SCI

作者：Zhang, Lihang;Xu, Juan;Gao, Jinchao;Wu, Yuncheng;Yin, Ming;Zhao, Wenjuan

出处：REVIEWS IN THE NEUROSCIENCES 2018

摘要：Neurons and microglia are two major components in the central nervous system (CNS). The interactions between them play important roles in maintaining ...

[外文期刊] Clinical features and subtypes of restless legs syndrome in Chinese population: a study of 359 patients SCI

作者：Zhu, Xiao-Ying;Wu, Ting-Ting;Wang, Hong-Ming;Ni, Ling-Yan;Li, Xuan;Liu, Ye;Zhang, Xiao-Jin;Chen, Ya-Jing;Cui, Xin-Xin;Ondo, William G.;Wu, Yun-Cheng

出处：SLEEP MEDICINE 2019

摘要：Background: The clinical spectrum of restless legs syndrome (RLS) has not been described in a Chinese population. We aim to evaluate the detailed clin ...

[外文期刊] Restless legs syndrome in end stage renal disease patients undergoing hemodialysis

作者：Lin, Xiao-Wei;Zhang, Jun-Fang;Qiu, Meng-Yao;Ni, Ling-Yan;Yu, Hong-Lei;Kuo, Sheng-Han;Ondo, William G.;Yu, Qing;Wu, Yun-Cheng

出处：BMC NEUROLOGY 2019

摘要：BackgroundThe prevalence of Restless legs syndrome (RLS) in End Stage Renal Disease (ESRD) patients is higher than that in the general population. How ...

[外文期刊] Magnetofection based on superparamagnetic iron oxide nanoparticle-mediated low lncRNA HOTAIR expression decreases the proliferation and invasion of glioma stem cells SCIE SCI

作者：Fang, Kan;Liu, Peifeng;Dong, Suyan;Guo, Yanjie;Cui, Xinxin;Zhu, Xiaoying;Li, Xuan;Jiang, Lianghan;Liu, Te;Wu, Yuncheng

出处：INTERNATIONAL JOURNAL OF ONCOLOGY 2016

摘要：Glioma stem cells (GSCs) are a special subpopulation of glioma cells that are key to the sensitivity of tumors to treatments and to the possibility of ...

[外文期刊] Hyperexpressed Netrin-1 Promoted Neural Stem Cells Migration in Mice after Focal Cerebral lschemia SCI

作者：Lu, Haiyan;Song, Xiaoyan;Wang, Feng;Wang, Guodong;Wu, Yuncheng;Wang, Qiaoshu;Wang, Yongting;Yang, Guo-Yuan;Zhang, Zhijun

出处：FRONTIERS IN CELLULAR NEUROSCIENCE 2016

摘要：Endogenous Netrin-1 (NT-1) protein was significantly increased after cerebral ischemia, which may participate in the repair after transient cerebral i ...

[外文期刊] A clinical memory battery for screening for amnestic mild cognitive impairment in an elderly chinese population SCI

作者：Zhao, Shengjie;Guo, Chunni;Wang, Mingqin;Chen, Weijie;Wu, Yuncheng;Tang, Wei;Zhao, Yongbo

出处：JOURNAL OF CLINICAL NEUROSCIENCE 2011

摘要：Amnestic mild cognitive impairment (MCI) might be more likely to progress to Alzheimer\'s disease than single non-memory MCI and multiple domain MCI. ...

[外文期刊] Stable suppression of Nurr1 gene using sirna expression vector in a mouse midbrain dopaminergic cell line SCIE SCI

作者：Wu, Y. C.;Zhao, Y. B.;Cai, Y. Q.;Fei, J.

出处：EUROPEAN JOURNAL OF NEUROLOGY 2006